Epidemiology of Developmental Dysplasia of the Hip: Analysis of Japanese National Database

Den, Hiroki; Ito, Junichi; Kokaze, Akatsuki

doi:10.2188/jea.je20210074

Cited by 19 publications

(37 citation statements)

References 25 publications

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“…Our initial search retrieved 1899 results, and we assessed 203 full texts. Ultimately, 76 studies 1 , 4 , 5 , 6 , 8 , 18 , 19 , 20 , 21 , 22 , 23 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 , 62 , 63 , 64 , 65 , 66 , 67 , 68 , 69 , 70 , 71 , 72 , 73 , 74 , …”

Section: Resultsunclassified

“…A total of 60 studies 1 , 4 , 5 , 8 , 18 , 19 , 20 , 21 , 22 , 23 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 , 62 , 63 , 64 , 65 , 66 , 67 , 68 , 69 , 70 , 71 , 72 , 73 , 74 , 75 including 8 670 492 newborns assessed the incidence of early-detected DDH. Of these, 10 studies…”

Section: Resultsmentioning

confidence: 99%

“…A total of 43 studies 5 , 8 , 18 , 20 , 21 , 22 , 23 , 28 , 29 , 31 , 35 , 36 , 37 , 38 , 39 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 55 , 56 , 59 , 60 , 61 , 64 , 65 , 67 , 68 , 72 , 74 , 76 , 77 , 78 , 79 , 80 including 4 488 951 newborns assessed the incidence of nonoperatively treated DDH. Of these, 5 studies 28 , 29 , 31 , 35 , 76 with 457 752 newborns used clinical screening, 20 studies 5 , 36 , 37 , 38 , 39 , 42 , 43 , 44 , 45 , 46 , 47 ,…”

Section: Resultsmentioning

confidence: 99%

“…A total of 43 studies 5,8,18,[20][21][22][23]28,29,31,[35][36][37][38][39][42][43][44][45][46][47][48][49][50][51][52][53]55,56,[59][60][61]64,65,67,68,72,74,[76][77][78][79][80] treatments per 1000 newborns and the lowest was 0.1 (95% CI, 0.0-0.3) treatments per 1000 newborns (Figure 3). The total pooled incidence estimates were 9.8 (95% CI, 6.7-14.4) treatments per 1000 newborns with universal ultrasonographic screening, 3.1 (95% CI, 2.0-4.8) treatments per 1000 newborns with selective ultrasonographic screening, and 5.4 (95% CI, 2.1-14.0) treatments per 1000 newborns with clinical screening.…”

Section: Incidence Of Nonoperative Treatmentmentioning

confidence: 99%

“…[36][37][38][39][40][41][42][43][44][45][46][47][48][49][50][51][52][53][54] with 7 884 989 newborns used selective screening, and 29 studies1,8,[18][19][20][21][22][23] with 233 609 newborns used universal ultrasonographic screening. The highest reported incidence was 120.3 (95% CI, 110.9-130.5) infants with DDH per 1000 newborns, and the lowest was 0.2 (95% 0.1-0.4) infants with DDH per 1000 newborns (Figure1).…”

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Incidence of Neonatal Developmental Dysplasia of the Hip and Late Detection Rates Based on Screening Strategy

et al. 2022

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ImportanceUniversal ultrasonographic screening for developmental dysplasia of the hip (DDH) has gained increasing popularity despite the lack of benefit in terms of reducing the rates of late-detected cases (age ≥12 weeks) in randomized clinical trials.ObjectiveTo report the reported incidence of DDH in the English scientific literature and compare rates of late-detected cases in settings with different DDH screening strategies.Data SourcesPubMed, Scopus, and Web of Science databases were searched on November 25 and 27, 2021. No time filters were used in the search.Study SelectionAll observational studies reporting the incidence of early-detected or late-detected (age ≥12 weeks) DDH were included. Non-English reports were excluded if the abstract did not include enough information to be included for analysis.Data Extraction and SynthesisThe number of newborns screened and the detection rates were extracted. Meta-analysis calculated the pooled incidence of DDH per 1000 newborns with 95% CIs using a random- or fixed-effects model. This study is reported according to the PRISMA and MOOSE guidelines.Main Outcomes and MeasuresThe main outcome measures were early detection, early treatment, late detection, and operative treatment incidences.ResultsA total of 1899 studies were identified, 203 full texts were assessed, and 76 studies with 16 901 079 infants were included in final analyses. The early detection rate was 8.4 (95% CI, 4.8-14.8) infants with DDH per 1000 newborns with clinical screening, 4.4 (95% CI, 2.4-8.0) infants with DDH per 1000 newborns with selective ultrasonographic screening, and 23.0 (95% CI, 15.7-33.4) infants with DDH per 1000 newborns with universal ultrasonographic screening. Rates for nonoperative treatment were 5.5 (95% CI, 2.1-14) treatments per 1000 newborns with clinical screening, 3.1 (95% CI, 2.0-4.8) treatments per 1000 newborns with selective ultrasonographic screening, and 9.8 (95% CI, 6.7-14.4) treatments per 1000 newborns with universal ultrasonographic screening. The incidence of late-detected DDH was 0.5 (95% CI, 0.2-1.5) infants with DDH per 1000 newborns with clinical screening, 0.6 (95% CI, 0.3-1.3) infants with DDH per 1000 newborns with selective ultrasonographic screening, and 0.2 (95% CI, 0.0-0.8) infants with DDH per 1000 newborns with universal ultrasonographic screening. The corresponding incidences of operative treatment were 0.2 (95% CI, 0.0-0.9) operations per 1000 newborns with clinical screening, 0.5 (95% CI, 0.4-0.7) operations per 1000 newborns with selective ultrasonographic screening, and 0.4 (95% CI, 0.2-0.7) operations per 1000 newborns with universal ultrasonographic screening.Conclusions and RelevanceThis meta-analysis found that early detection rates and nonoperative treatments were higher with universal screening. The late detection and operative treatment rates with universal screening were similar to those among selectively and clinically screened newborns. Based on these results, universal screening may cause initial overtreatment without reducing the rates of late detection and operative treatment.

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Section: Resultsunclassified

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Incidence Of Nonoperative Treatmentmentioning

confidence: 99%

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Incidence of Neonatal Developmental Dysplasia of the Hip and Late Detection Rates Based on Screening Strategy

et al. 2022

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Epidemiology of patients with lymphangioleiomyomatosis: A descriptive study using the national database of health insurance claims and specific health checkups of Japan

Kimura,

Jo,

Hashimoto

et al. 2024

Respiratory Investigation

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Diagnostic accuracy of a deep learning model using YOLOv5 for detecting developmental dysplasia of the hip on radiography images

Den

Ito

Kokaze

2023

Sci Rep

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Developmental dysplasia of the hip (DDH) is a cluster of hip development disorders and one of the most common hip diseases in infants. Hip radiography is a convenient diagnostic tool for DDH, but its diagnostic accuracy is dependent on the interpreter’s level of experience. The aim of this study was to develop a deep learning model for detecting DDH. Patients younger than 12 months who underwent hip radiography between June 2009 and November 2021 were selected. Using their radiography images, transfer learning was performed to develop a deep learning model using the “You Only Look Once” v5 (YOLOv5) and single shot multi-box detector (SSD). A total of 305 anteroposterior hip radiography images (205 normal and 100 DDH hip images) were collected. Of these, 30 normal and 17 DDH hip images were used as the test dataset. The sensitivity and the specificity of our best YOLOv5 model (YOLOv5l) were 0.94 (95% confidence interval [CI] 0.73–1.00) and 0.96 (95% CI 0.89–0.99), respectively. This model also outperformed the SSD model. This is the first study to establish a model for detecting DDH using YOLOv5. Our deep learning model provides good diagnostic performance for DDH. We believe our model is a useful diagnostic assistant tool.

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Epidemiology of Developmental Dysplasia of the Hip: Analysis of Japanese National Database

Abstract: This article has been accepted for publication and undergone full peer review but has not been through the copyediting, typesetting, pagination and proofreading process which may lead to differences between this version and the Version of Record.

Cited by 19 publications

References 25 publications

Incidence of Neonatal Developmental Dysplasia of the Hip and Late Detection Rates Based on Screening Strategy

Incidence of Neonatal Developmental Dysplasia of the Hip and Late Detection Rates Based on Screening Strategy

Epidemiology of patients with lymphangioleiomyomatosis: A descriptive study using the national database of health insurance claims and specific health checkups of Japan

Diagnostic accuracy of a deep learning model using YOLOv5 for detecting developmental dysplasia of the hip on radiography images

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