Epidemiology of Drug Resistant Tuberculosis in Samtse General Hospital, Bhutan: A Retrospective Study

Dorji, Thinley

doi:10.3126/saarctb.v17i1.25027

Cited by 2 publications

(2 citation statements)

References 9 publications

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“…Similarly a nationwide study on EPTB in Bhutan showed TSR of 90% [ 8 ]. The lowest TSR for Samtse General Hospital was observed in 2013 which might be due to increased detection of drug resistant TB [ 14 ] after the introduction of liquid culture in Bhutan. The TSR of Samtse General Hospital increased from 83% in 2013 to 89% in 2019.…”

Section: Discussionmentioning

confidence: 99%

Treatment outcome of tuberculosis patient of Samtse General Hospital, Bhutan

Dorji¹,

Wangdi

2020

Nepal J Epidemiology

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Background: Tuberculosis (TB) is one of the major public health problems in Bhutan. Evaluation of treatment outcomes of TB and identification of the risk factors are important components for the success of National TB control program. Therefore, this study was undertaken to assess the TB treatment outcome and factors associated with it in Samtse General Hospital. Methods: This was a retrospective, cross sectional study using the TB data from Samtse General Hospital from 2008–2019. A univariate and multiple logistic regression was used to check for associations between the outcome and other independent variables. Results: The study included a total of 634 TB patients. Of this, 44.0% (279) were smear positive TB (PTB+), 36.1% (229) were extra pulmonary TB (EPTB) and 19.9% (126) were smear negative TB (PTB-). During the study period, 56.2% (356) of them completed treatment, 33.3% (211) were declared cured, 0.2% (1) had defaulted, 5.1% (32) died and 5.4% (34) had treatment failure. The mean treatment success rate (TSR) was 89.4% (567). The TSR was highest for EPTB with 96.9% (222/229), followed by PTB- at 88.1% (111/126) and lowest for PTB+ with 83.9% (234/279). Successful treatment outcome was observed in EPTB patients (AOR: 7.3; 95% CI: 2.46-21.36), patients in age 15-28 years (AOR: 3.4; 95% CI: 1.59-7.46) and 29-42 years (AOR: 9.1; 95% CI: 2.44-33.61). Conclusion: The treatment outcome of TB in Samtse General Hospital is satisfactory and at par with the national level. Since, smear positive TB and elderly patients are prone to develop poor treatment outcome, they need to be monitored and followed up adequately.

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Section: Discussionmentioning

confidence: 99%

Treatment outcome of tuberculosis patient of Samtse General Hospital, Bhutan

Dorji¹,

Wangdi

2020

Nepal J Epidemiology

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“…In Bhutan, it was found that the mean prevalence rate of MDR-TB was 16%. The burden of primary MDR-TB and secondary MDR-TB is higher in Bhutan (primary 13% and secondary −35%) than other South East Asian countries (Primary −2.7% and secondary −13%) and globally (Primary − 3.5% and secondary 18%) [9] .…”

Section: Introductionmentioning

confidence: 86%

Audiological monitoring of patients undergoing multidrug resistant tuberculosis treatment at Jigme Dorji Wangchuk National Referral Hospital and Gidakom Hospital, Bhutan

Wangchuk

Adhikari

Nima

et al. 2021

Journal of Clinical Tuberculosis and Other Mycobacterial Diseas

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Background Hearing impairment due to ototoxicity is one common cause adding to global burden of disability. Amikacin and kanamycin are two common Aminoglycosides used to treat multidrug resistant tuberculosis which results in ototoxicity. The mean prevalence rate of multidrug resistant tuberculosis in Bhutan stood at 16%. Objective The study is aimed to establish prevalence rate of hearing impairment due to ototoxicity and secondary side effects which may ascertain specific early intervention. Method A total of 42 Patients undergoing multidrug resistant tuberculosis treatment participated in the study conducted at Jigme Dorji Wangchuk National Referral Hospital and Gidakom Hospital over a period of one year. Audiological tests were conducted once every month. The severity of ototoxicity was being graded using Brock's hearing loss grades. Result The study found 45.23% participants with some degree of hearing loss consequent to multidrug resistant tuberculosis treatment. Around 9.5% of the total participants developed potential disabling hearing loss. Around 30.09% of participants had experienced subjective tinnitus during the course of treatment. Study found no significant association (p-value 0.88, 95%CI 0.93–1.00) between referred test result of DPOAE (distortion product Otoacoustic emission) screener and the ototoxicity. Conclusion Study showed with significant prevalence of ototoxicity. Since hearing impairment have negative impact on psychosocial wellbeing and communication abilities, it is paramount importance to put in place the various preventative measures. With current guidelines by World Health Organisation on replacement of second-line injectable by oral regimens while treating patients with MDR-TB, it is expected to address ototoxicity and related issues.

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Epidemiology of Drug Resistant Tuberculosis in Samtse General Hospital, Bhutan: A Retrospective Study

Cited by 2 publications

References 9 publications

Treatment outcome of tuberculosis patient of Samtse General Hospital, Bhutan

Treatment outcome of tuberculosis patient of Samtse General Hospital, Bhutan

Audiological monitoring of patients undergoing multidrug resistant tuberculosis treatment at Jigme Dorji Wangchuk National Referral Hospital and Gidakom Hospital, Bhutan

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