Treatment outcome of tuberculosis patient of Samtse General Hospital, Bhutan

Dorji, Thinley; Wangdi, Kinley

doi:10.3126/nje.v10i3.28397

Cited by 3 publications

(3 citation statements)

References 17 publications

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“…Studies underscore the elevated likelihood of etiologically positive PTB among farmers in China [41]. Furthermore, our study, alongside existing research, indicates a lower successful treatment rate for etiologically positive PTB compared to negative cases, as well as for retreated PTB patients compared to initial treatment [42][43][44][45].…”

Section: Discussionsupporting

confidence: 58%

“…Our study revealed a commendable successful treatment rate exceeding 90% (95.77%) among PTB patients in Guizhou Province, positioning it favorably in comparison to both domestic and international counterparts [28][29][30]. However, the curative outcome for PTB in Guizhou Province remained suboptimal at 42.54%, indicating a notable disparity when juxtaposed against the 50-73% cure rates observed in other Chinese regions [31][32][33].…”

Section: Discussionmentioning

confidence: 71%

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Multivariate regression analysis affecting successful treatment of pulmonary tuberculosis patients in western China: a retrospective study in a high-incidence area

Zhou,

Li,

et al. 2024

Preprint

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Background Guizhou, situated in western China, exhibits a high incidence of pulmonary tuberculosis (PTB) alongside comparatively challenging medical and economic conditions. Our objective was to investigate the determinants influencing successful PTB treatment and their scope, aiming to provide a scientific foundation for targeted interventions and enhancing treatment efficacy. Methods Data encompassing all PTB cases registered in Guizhou's China Disease Prevention and Control Information System from 2017 to 2022 were analyzed. Using the successful treatment rate as the dependent variable, initial univariate analysis of independent variables was conducted, followed by multilevel binary logistic regression analysis to assess variables demonstrating statistically significant disparities. Results A total of 139,414 patients, with an average age of 44 years, were included in the study, comprising 89,802 males (64.41%) and 49,612 females (35.59%). Among them, 66,316 (47.57%) were etiologically positive, and 22,795 (16.35%) had comorbidities. The successful treatment rate stood at 95.77%, with a cure rate of 42.54%. 9 factors were identified to influence the successful treatment rate. These included a higher proportion of females compared to males (OR = 1.178, 95%CI = 1.111–1.249), a higher ratio of students versus farmers (OR = 1.960, 95%CI = 1.649–2.330), and a greater proportion of etiologically negative cases compared to etiologically positive (OR = 1.831, 95%CI = 1.725–1.942). Additionally, initial treatment showed higher success rates than retreatment (OR = 3.046, 95%CI = 2.836–3.272), and PTB patients without comorbidities fared better than those with comorbidities (OR = 1.303, 95% CI = 1.217–1.394). The use of fixed-dose combination (FDC) therapy yielded higher success rates than non-FDC treatment (OR = 1.296, 95%CI = 1.206–1.393). Furthermore, successful treatment rates were lower among the Miao ethnic group (OR = 0.874, 95%CI = 0.809–0.945) and higher among the Buyi (OR = 1.270, 95%CI = 1.137–1.419) compared to the Han. Age also played a significant role, with lower success rates observed in the 41–60 age group (OR = 0.731, 95%CI = 0.638–0.838) and the lowest rates among those aged 61 years and older (OR = 0.604, 95%CI = 0.527–0.693). Conclusions Western China faces ongoing challenges in enhancing its PTB treatment capacity and should prioritize the promotion of FDC therapy. Risk factors that influence treatment outcomes for PTB include male gender, advanced age, belonging to the Miao ethnic group, occupation as a farmer, etiological positivity, retreatment status, and comorbidities such as diabetes and HIV/AIDS. Further investigation is warranted to explore the disparities in successful treatment rates among different ethnicities.

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Section: Discussionsupporting

confidence: 58%

Section: Discussionmentioning

confidence: 71%

Multivariate regression analysis affecting successful treatment of pulmonary tuberculosis patients in western China: a retrospective study in a high-incidence area

Zhou,

Li,

et al. 2024

Preprint

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“…The mean treatment success rate of above WHO recommended cutoff of 90% (93%) in the study district is comparable to national [ 22 , 23 ] and other countries in the region including Bangladesh (94%), Nepal (91%), Sri Lanka (85%), Pakistan (93%) [ 24 ] and Ethiopia (92.5%) [ 25 ]. This is in line with the recommended target of the End TB Strategy set by the WHO [ 2 , 18 ].…”

Section: Discussionsupporting

confidence: 51%

The trend of tuberculosis case notification and predictors of unsuccessful treatment outcomes in Samdrup Jongkhar district, Bhutan: A fourteen-year retrospective study

Penjor¹,

Kuenzang²,

Tshokey³

et al. 2021

Heliyon

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Tuberculosis (TB) continues to be an important public health issue in Bhutan. This study aims to describe the trend of tuberculosis and investigate factors associated with a unsuccessful treatment outcome in Samdrup Jongkhar District in Bhutan. A fourteen-year (2004–2017) case records in two TB centres of Dewathang and Samdrup Jongkhar Hospitals were reviewed and analyzed to examine trends in case notification and treatment outcomes. Univariable and multivariable logistic regression analysis was undertaken to identify covariates of unsuccessful TB treatment. Of the total of 820 TB cases registered in surveillance record, 729 cases were analysed. Males made up 53.8% (397) of total cases and the median age was 29 years (range: 2–87 years). A gradual downward trend in TB case notification was noticed in the district with overall case notification rate of 139/100,000 during the study period. The annual treatment success rate was over 90% except for years 2013–2015 with overall treatment success rate for the study period at 93%. A re-treatment TB patient, sputum-positive at the second month of treatment and being of Indian nationality were significant correlates of unsuccessful treatment outcomes. The overall TB inclidence has declined and TB treatment success rate was above WHO recommended 90% in Samdrup Jongkhar District during the study period. A special attention should be paid to the poor treatment outcome predictors including re-treatment cases and failed sputum conversion at the second month of treatment.

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High incidence of multidrug-resistant tuberculosis in Bhutan: A cohort study based on national TB surveillance data

Dorji,

Tshering,

Adhikari

et al. 2024

IJID Regions

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Treatment outcome of tuberculosis patient of Samtse General Hospital, Bhutan

Cited by 3 publications

References 17 publications

Multivariate regression analysis affecting successful treatment of pulmonary tuberculosis patients in western China: a retrospective study in a high-incidence area

Multivariate regression analysis affecting successful treatment of pulmonary tuberculosis patients in western China: a retrospective study in a high-incidence area

The trend of tuberculosis case notification and predictors of unsuccessful treatment outcomes in Samdrup Jongkhar district, Bhutan: A fourteen-year retrospective study

High incidence of multidrug-resistant tuberculosis in Bhutan: A cohort study based on national TB surveillance data

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