Epidemiology of dust-mite-related disease

Sporik, Richard; Platts‐Mills, Thomas A.E.

doi:10.1007/bf01201497

Cited by 31 publications

(13 citation statements)

References 43 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the 1980s, the theory that exposure to house dust mites and other allergens was an important worldwide cause of the disease was espoused by many scientists and experts (2,3). This theory was based on strong evidence suggesting that, in regions where indoor exposure to one of the main house dust mite allergens (Der p I) was high, more children were sensitized to house dust mites, and these children had significantly more airway hyperresponsiveness and recent wheeze (4).…”

Section: The Centrality Of Environmental Exposures As a Unifying Theomentioning

confidence: 99%

Gene-Environment Interactions in Asthma: With Apologies to William of Ockham

Martínez¹

2007

Proceedings of the American Thoracic Society

View full text Add to dashboard Cite

Many environmental factors and a large number of genetic polymorphisms have been reported to be associated with asthma risk in different locales and at different ages. It seems that what we call asthma is a heterogeneous set of conditions for which the only common feature is recurrent airway obstruction that is at least partially responsive to usual asthma therapy. Recent studies in which environmental factors and genetic variants were studied concomitantly have suggested a potential unifying concept for the disease. It seems that asthma is a genetically mediated development dysregulation of diverse immune and airway responses to a variety of specific and nonspecific exposures. It thus seems improbable that most genetic variants associated with asthma influence the disease regardless of which environmental factors trigger it and at which lifetime phase they are present. More likely, the most important gene variants for asthma are polymorphisms that exert their influence on the network system controlling biological responses to asthma-related exposures.

show abstract

Section: The Centrality Of Environmental Exposures As a Unifying Theomentioning

confidence: 99%

Gene-Environment Interactions in Asthma: With Apologies to William of Ockham

Martínez¹

2007

Proceedings of the American Thoracic Society

View full text Add to dashboard Cite

show abstract

“…HDM was shown to be associated with development of asthma [13,14]. However, outdoor allergens such as pollen can be an important trigger of asthma [15].…”

Section: Introductionmentioning

confidence: 99%

The relationship of aeroallergen sensitization phenotypes to asthma control in primarily Hispanic asthmatic children

et al. 2013

View full text Add to dashboard Cite

show abstract

“…Sensitivity to house dust was confirmed in the 1920s by studies showing positive skin prick tests to house dust in many asthmatic individuals [1]. Such studies sparked scientific interest into what specific component of house dust was responsible for the sensitisation but it was not until the 1960s that Voorhorst and colleagues discovered Dermatophagoides pteronyssinus to be the major producer of house dust allergen [2, 3].…”

Section: Introductionmentioning

confidence: 99%

“…In particular, the evidence for asthma is strong enough that a causal relationship is widely accepted [1]. …”

Section: Introductionmentioning

confidence: 99%

“…To our knowledge there have been no published studies on the effect of endotoxin on the APT. Direct cutaneous house dust mite allergen exposure has been associated with exacerbation of atopic eczema, and allergen avoidance has been shown to significantly improve eczema as measured by SCORAD [1]. If endotoxin enhances this effect, the clinical implications could be significant.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Do Other Components of Bedding Dust Affect Sensitisation to House Dust Mites?

et al. 2011

View full text Add to dashboard Cite

Bedding dust is a mixture of many components, of which the house dust mite (HDM) allergen, Der p 1, is the most allergenic. There has been little work to investigate the effect of other bedding dust components on HDM sensitisation. The objective of the study was to determine the effect of endotoxin in bedding dust on the allergic response in HDM-sensitised individuals. Twenty-nine house dust mite-sensitised adults were skin prick and allergen patch tested against a sterile solution of their own bedding dust and against a solution containing the same concentration of Der p 1 as the bedding solution for comparison. There was no significant difference in wheal size between the diluted house dust mite solution and the bedding dust in spite of their high levels of endotoxin. Symptomatic subjects had larger, but not statistically significant, responses to commercial house dust mite solution than asymptomatic subjects. Allergen patch test responses were negative in 22/29 of subjects using either bedding dust solutions or comparable diluted house dust mite solutions. An individual's own bedding dust does not appear to contain factors that enhance skin prick test or atopy patch test responses to house dust mites.

show abstract

Epidemiology of dust-mite-related disease

Cited by 31 publications

References 43 publications

Gene-Environment Interactions in Asthma: With Apologies to William of Ockham

Gene-Environment Interactions in Asthma: With Apologies to William of Ockham

The relationship of aeroallergen sensitization phenotypes to asthma control in primarily Hispanic asthmatic children

Do Other Components of Bedding Dust Affect Sensitisation to House Dust Mites?

Contact Info

Product

Resources

About