Epidemiology of endometriosis and its comorbidities

Parazzini, Fabio; Esposito, Giovanna; Tozzi, Luca; Noli, S; Bianchi, Stefano

doi:10.1016/j.ejogrb.2016.04.021

Cited by 237 publications

(196 citation statements)

References 41 publications

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“…32 The characteristics of our trial population of premenopausal women with endometriosis were similar to those of patients in epidemiologic studies of endometriosis and chronic pelvic pain. [37][38][39] The safety and efficacy results of Elaris EM-II confirmed the results of Elaris EM-I, which showed the internal validity. The two trials were limited by the entry criteria and length of the intervention period.…”

Section: Discussionsupporting

confidence: 66%

Treatment of Endometriosis-Associated Pain with Elagolix, an Oral GnRH Antagonist

et al. 2017

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Section: Discussionsupporting

confidence: 66%

Treatment of Endometriosis-Associated Pain with Elagolix, an Oral GnRH Antagonist

et al. 2017

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“…The disease has a peak between 25 and 35 years of age and is estimated to affect 7-10% of women. The percentage of patients experiencing severe symptoms or complications is about 3% of women at a fertile age [4,7]. The pathogenesis of endometriosis is not fully understood, but the most accepted theory suggests retrograde menstruation as the etiology of this disease.…”

Section: Discussionmentioning

confidence: 99%

“…Endometriosis is a benign gynecological disease, estimated to affect 7-10% of women [4]. The bowel is the most affected extragenital location, with a prevalence of 3-12%, especially in the rectosigmoid junction (50-90%) [5].…”

Section: Introductionmentioning

confidence: 99%

Endometriosis: A Rare Cause of Large Bowel Obstruction

Alexandrino

Lourenço

Carvalho

et al. 2017

GE Port J Gastroenterol

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Large bowel obstruction can result in significant morbidity and mortality, especially in cases of acute complete obstruction. There are many possible causes, the most common in adults being colorectal cancer. Endometriosis is a benign disease, and the most affected extragenital location is the bowel, especially the rectosigmoid junction. However, transmural involvement and acute occlusion are very rare events. We report an exceptional case of acute large bowel obstruction as the initial presentation of endometriosis. The differential diagnosis of colorectal carcinoma may be challenging, and this case emphasizes the need to consider intestinal endometriosis in females at a fertile age presenting with gastrointestinal symptoms and an intestinal mass causing complete large bowel obstruction.

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“…The pathogenesis of endometriosis is not well understood, and the development of this disease is affected by various genetic and environmental factors (McLeod and Retzloff, 2010;Parazzini et al, 2016). It has been reported that mutations in genes related to hormone receptor, matrix metalloproteinase, inflammatory factor and angiotensin I-converting enzyme (Lamp et al, 2010;Abutorabi et al, 2015;Kerimoglu et al, 2015;Yang et al, 2016) may contribute to disease onset.…”

Section: Introductionmentioning

confidence: 99%

“…Endometriosis is a common gynecological disease with a 20% morbidity rate, and it impacts both a women's physical and mental well being (McLeod and Retzloff, 2010;Parazzini et al, 2016). The pathogenesis of endometriosis is not well understood, and the development of this disease is affected by various genetic and environmental factors (McLeod and Retzloff, 2010;Parazzini et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

Association between CYP19A1, GSTM1, GSTT1, and GSTP1 genetic polymorphisms and the development of endometriosis in a Chinese population

Tuo¹,

He²,

Yan³

et al. 2016

Genet. Mol. Res.

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ABSTRACT. Endometriosis is a common, complicated, and highly heterogeneous endocrine disease. Many genetic factors could affect the development of endometriosis. We performed a case-control study to evaluate the association between polymorphisms in CYP19A1 rs2899470, GSTM1, GSTT1, and GSTP1 rs1695 and the development of endometriosis in a Chinese population. Between March 2014 and October 2015, 262 endometriosis patients and 275 control subjects were recruited from the Inner Mongolia Medical University. Genotyping was conducted using polymerase chain reaction-coupled with restriction fragment length polymorphism. Individuals carrying the TT genotype of CYP19A1 rs2899470 expressed a higher risk of endometriosis than those carrying the GG genotype, and the adjusted ORs (95%CI) was 2.33 (1.27-4.33). Moreover, those with the TG + TT genotype were correlated with an elevated risk of endometriosis, compared to those with the GG genotype (OR = 1.48, 95%CI = 1.03-2.13). However, GSTM1, GSTT1, and GSTP1 rs1695 polymorphisms did not affect the pathogenesis of endometriosis. In conclusion, our results suggested that CYP19A1 rs2899470 polymorphism is associated with risk for endometriosis in the Chinese population.

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Epidemiology of endometriosis and its comorbidities

Cited by 237 publications

References 41 publications

Treatment of Endometriosis-Associated Pain with Elagolix, an Oral GnRH Antagonist

Treatment of Endometriosis-Associated Pain with Elagolix, an Oral GnRH Antagonist

Endometriosis: A Rare Cause of Large Bowel Obstruction

Association between CYP19A1, GSTM1, GSTT1, and GSTP1 genetic polymorphisms and the development of endometriosis in a Chinese population

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