Epidemiology of Hepatitis C Virus Infection in Egypt

Amer, Fatma; Gohar, Maha Kamal; Yousef, M.T.

doi:10.9734/ijtdh/2015/15727

Cited by 27 publications

(20 citation statements)

References 66 publications

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“…Chronic HCV was the commonest etiology of cirrhosis in both groups (95%) in GI and (91.7%) in GII. This result agreed with the study done by Amer et al [21] who reported that, the prevalence of HCV infection in Egypt is the highest reported worldwide of 14.7% and about 85% of those infected with HCV will develop chronic hepatitis of varying severity, nearly 20% of patients develop cirrhosis in 10-20 years.…”

Section: Between Giii and Gi P2:between Giii And Giia P3:between supporting

confidence: 93%

The Role of Renal Resistive Index in Assessment of Functional Renal Impairment in Patients with Liver Cirrhosis

EL-Lehleh

Mageed

et al. 2017

Afro-Egyptian Journal of Infectious and Endemic Diseases

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Background and study aim: Renal dysfunction often develops in patients with liver cirrhosis. Hepatorenal syndrome (HRS) represents the end-stage of reduction in renal perfusion. Duplex Doppler ultrasonography of the kidneys is a noninvasive method to assess blood flow and arterial vascular resistance as a parameter for vasoconstriction. This study aimed to assess the role of renal resistive index as a non-invasive marker for early detection of functional renal impairment in patients with liver cirrhosis. Patients and Methods: This study was conducted on 20 patients with liver cirrhosis without ascites vs. 60 patients with liver cirrhosis and ascites and 20 healthy subjects as control group. Patients and control were subjected to complete blood picture, liver and kidney functions, serum electrolytes, twenty four hours urinary sodium, abdominal ultrasonography and duplex Doppler evaluation of the renal arteries with calculation of mean renal RI. Results: Highly significant difference between cirrhotic patients with ascites and cirrhotic patients without ascites and controls regarding mean renal resistive index for both kidneys (P<0.001). At Cutoff point of renal RI 0.71, the sensitivity, specificity and accuracy to predict HRS were 100%, 80% and 82% respectively with AUC= 0.997. A statistical high significant positive correlation between RI and serum creatinine, child class, MELD score and MELD-Na (r=0. 0.818, r= 0. 0.539, r= 0.739 r= 0.807 respectively and P<0.001). A statistical high significant negative correlation between RI and serum sodium, 24 hours urinary sodium, and platelets (r=-0.778, r= 0.-0.688, r=-0.422 respectively and P<0.001). Conclusion: Renal duplex Doppler ultrasound is useful as a non-invasive method for the evaluation of the renal hemodynamic changes in cirrhotic patients and can predict HRS.

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Section: Between Giii and Gi P2:between Giii And Giia P3:between supporting

confidence: 93%

The Role of Renal Resistive Index in Assessment of Functional Renal Impairment in Patients with Liver Cirrhosis

EL-Lehleh

Mageed

et al. 2017

Afro-Egyptian Journal of Infectious and Endemic Diseases

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“…Mohlman et al [28] reported that not a statistically significant assоciatiоn between HCV pоsitivity and blооd dоnation [28]. However, many оther studies repоrted that, there is relation between these risk factors and increasing prevalence of anti-HCV [19,34,38,39].…”

Section: Discussionmentioning

confidence: 99%

Seroprevalence of Hepatitis C Virus among Population in Luxor Governorate, Egypt

2017

JHVRV

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Background: Hepatitis C virus (HCV) is one of the hepatitis viruses that transmitted through blоod or blоod products. HCV has been implicated as a major reason of chronic liver disease and hepatоcellular carcinoma worldwide. Aim:To determine the seroprevalence of HCV antibodies among community in Luxor governorate, Egypt. Moreover to assess if there is any association with the population group, sex, age and other different risk factors. Method:We randomly selected 745 blood samples; from males and females of different ages. Samples were collected from Luxor governorate, Egypt. Seras from all subjects were tested for hepatitis C virus antibodies using rapid test method and confirmed with the enzyme linked immunosorbent assay (ELISA) third generation. Results:Our results show that 584 (78.40 %) of the community were males and most of them were aged between 31 and 50 years. Thirty two (5.48%) from blood samples of males were anti-HCV seropositive and the highest prevalence of anti-HCV (7.22%) of age groups from 41-50 years. One hundred and sixty one (21.60%) from the community were female and most of them aged between 41 -65 years. Six (3.73%) of female subjects tested positive for anti-HCV and the highest prevalence of anti-HCV (4.87%) with age groups from 31-40 years. Four risk factors reflecting high mechanisms of HCV transmission have been associated with HCV infection including residing in rural areas, no education, blood transfusion and dental treatment. Exposures to surgery, history of schistosomiasis show low association with Anti-HCV. Among the community exposures, including blood donation and alcohol consumption but these associations are not important.

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“…Egypt ranks first among countries regarding the prevalence of hepatitis C virus (HCV) infection (Amer et al, 2015). Many patients have associated diseases like kidney disorders that necessitate hemodialysis (HD).…”

Section: Introductionmentioning

confidence: 99%

Surveillance and impact of occult hepatitis B virus, SEN virus, and torque teno virus in Egyptian hemodialysis patients with chronic hepatitis C virus infection

Amer

Yousif

Mohtady

et al. 2020

International Journal of Infectious Diseases

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Egypt ranks first regarding the prevalence of hepatitis C virus (HCV) infection. Many patients have concomitant diseases like kidney disorders requiring hemodialysis, a procedure carrying the hazard of transmitting other hepatitis viruses. The purpose of this study was to investigate for occult hepatitis B virus (HBV), SEN virus (SENV), and torque teno virus (TTV) among chronic HCV patients on maintenance hemodialysis to identify their impacts. Methods: A total of 325 hemodialysis patients were enrolled and divided into two groups based on HCV RNA testing results. Blood samples were collected before hemodialysis. Sera were tested for hepatitis B core antibodies (anti-HBc) and hepatitis B surface antibodies (anti-HBs) using ELISA. HBV, SENV, and TTV DNA were detected by PCR. The serum alanine aminotransferase (ALT) level was measured. Results: Anti-HBc and HBV DNA were detected in 73.1% and 50.8% of group 1 versus 36.4% and 22.6% of group 2. The serum ALT level was higher in group 1 than group 2. SENV was detected in 11.5% of group 1 versus 8.2% of group 2. TTV was detected in 29% of group 1 versus 27% of group 2. Conclusions: There is an increased prevalence of occult HBV in our locality among chronic HCV patients undergoing hemodialysis. The existence of SENV and TTV viremia has no clinical impact.

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Epidemiology of Hepatitis C Virus Infection in Egypt

Cited by 27 publications

References 66 publications

The Role of Renal Resistive Index in Assessment of Functional Renal Impairment in Patients with Liver Cirrhosis

The Role of Renal Resistive Index in Assessment of Functional Renal Impairment in Patients with Liver Cirrhosis

Seroprevalence of Hepatitis C Virus among Population in Luxor Governorate, Egypt

Surveillance and impact of occult hepatitis B virus, SEN virus, and torque teno virus in Egyptian hemodialysis patients with chronic hepatitis C virus infection

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