Epidemiology of human papillomavirus infection among fishermen along Lake Victoria Shore in the Kisumu District, Kenya

Ngayo, Musa Otieno; Bukusi, Elizabeth A.; Rowhani-Rahbar, Ali; Koutsky, Laura A.; Feng, Qinghua; Kwena, Zachary; Holmes, King K.

doi:10.1136/sti.2007.027508

Cited by 37 publications

(40 citation statements)

References 28 publications

(31 reference statements)

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“…Similar observations about sexual risk behaviour and an association with HPV have been made in studies of men in SSA. [10,17,28] While the data on the protective effects of condoms are somewhat mixed, [35] evidence from African studies in men show a reduced risk of genital HPV infection associated with condom use. [10,28,36,37] Evidence from randomised controlled trials (RCTs) of MC has conclusively demonstrated the protective benefits of MC in reducing the risk of HPV prevalence and incidence.…”

Section: Factors Associated With Hpv Infectionmentioning

confidence: 99%

“…[10,17,28] While the data on the protective effects of condoms are somewhat mixed, [35] evidence from African studies in men show a reduced risk of genital HPV infection associated with condom use. [10,28,36,37] Evidence from randomised controlled trials (RCTs) of MC has conclusively demonstrated the protective benefits of MC in reducing the risk of HPV prevalence and incidence. [17,36,38,39] Related findings from the trial in Kenya have highlighted less frequent bathing as a risk factor for HPV infection, which may be associated with poor genital hygiene in uncircumcised men.…”

Section: Factors Associated With Hpv Infectionmentioning

confidence: 99%

“…[3,27] Data emerging from Africa, present a similarly mixed picture. A study among Kenyan fishermen showed a lower risk for HPV infection in older age groups, [10] while data from Kenyan men participating in an MC trial showed little variation in prevalence with age. [28] A more recent study in men from Tanzania demonstrated an association between increasing age and HPV prevalence, but that this association was driven by HIVpositive men.…”

Section: Factors Associated With Hpv Infectionmentioning

confidence: 99%

“…[9] Although data on anogenital HPV DNA prevalence in men in SSA are also limited, [3] overall reported prevalences in men are high, ranging from 19% to 78%. [10][11][12][13][14][15] In most, but not all studies, the most prevalent type was HPV-16. [15] The observed heterogeneity in estimates can be attributed to differences in age distribution, sexual behaviour and HIV prevalence within the different populations.…”

Section: Burden Of Infection In Ssamentioning

confidence: 99%

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Human papillomavirus infection and disease in men: Impact of HIV

Delany‐Moretlwe

Chikandiwa

Gibbs

2013

South. Afr. j. HIV med.

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There is growing evidence of a significant burden of human papillomavirus (HPV) infection and associated disease in men. High rates of HPV infection have been observed in men from sub-Saharan Africa where HIV prevalence is high. HIV infection increases HPV prevalence, incidence and persistence and is strongly associated with the development of anogenital warts and anal, penile and head and neck cancers in men. Despite increasing access to antiretroviral therapy, there appears to be little benefit in preventing the development of these cancers in HIV-positive men, making prevention of infection a priority. New prevention options that are being introduced in many African countries include male circumcision and HPV vaccination. However, more data are needed on the burden of HPV disease in men before boys are included in HPV vaccination programmes. Human papillomavirus (HPV) is a common sexually transmitted infection (STI) affecting both men and women. S Afr J HIV Med[1] HPV infections can be classified as either low-(LR) or high-risk (HR).[2]HR-HPV infections have been associated with cancer of the anogenital and oropharyngeal tissues. While the majority of HPV infections are transient and clear spontaneously, persistent infection with HR-HPV is associated with the development of pre-neoplastic and neoplastic lesions in these areas (Fig. 1). While much is known about the natural history of HPV infection in cervical cancer in women, less is known about the development of HPV-associated disease in men. Emerging evidence points to a significant role for HIV infection in promoting HPV prevalence, incidence and persistence. This review provides an update on current evidence regarding the epidemiology of HPV infection and disease in men, the effects of HIV on HPV infection and disease in men in sub-Saharan Africa (SSA), and the prospects for prevention in this setting. Global burden of HPVHPV infection is ubiquitous in men. A systematic review of 62 studies using reliable methods of HPV DNA detection and conducted prior to 2009, representing 14 800 men in 23 countries, showed that anogenital HPV DNA prevalence is generally high in sexually active men. The review highlighted considerable variation in estimates by region, from 1% to 84% in LR men, to 2% to 93% in HR men. [3] Compared with studies in women, peak prevalence spanned a wide range of ages, suggesting that men have the potential for longer-term persistence of infection or higher rates of re-infection.[3] Typespecific HPV seroprevalence studies are better indicators of lifetime exposure to HPV infection, although they may underestimate cumulative HPV exposure, given that not all infections lead to seroconversion.[4] Recent population-based studies have estimated the prevalence of antibodies to vaccinepreventable HPV types 6, 11, 16 and 18. Among men aged 14 -59 years in the USA, 12.2% of men were seropositive for any vaccine type, with a peak prevalence of 18% among men aged 50 -59 years.[5] In a similar population-based study in Australia, peak prevalence of any...

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Section: Factors Associated With Hpv Infectionmentioning

confidence: 99%

Section: Factors Associated With Hpv Infectionmentioning

confidence: 99%

Section: Factors Associated With Hpv Infectionmentioning

confidence: 99%

Section: Burden Of Infection In Ssamentioning

confidence: 99%

See 2 more Smart Citations

Human papillomavirus infection and disease in men: Impact of HIV

Delany‐Moretlwe

Chikandiwa

Gibbs

2013

South. Afr. j. HIV med.

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“…Communities in border regions of Tanzania and elsewhere in East Africa comprise mobile groups such as fisher folk, seafarers, truck drivers, cross-border traders and a resident community. Even resident communities are relatively fluid; the border area attracts people, for longer or shorter periods of time, in search of business opportunities such as petty trade, sex-work or employment in small scale restaurants and bars around the border sites [5][6][7][8] .…”

Section: Introductionmentioning

confidence: 99%

Sexual and reproductive health and HIV in border districts affected by migration and poverty in Tanzania

Obel

Larsson

Sodemann

2014

The European Journal of Contraception & Reproductive Health

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Objectives To assess HIV knowledge, attitudes, sexual practices and sexual and reproductive health (SRH) service delivery in border areas of Tanzania, with a view to support the prioritisation of SRH interventions in border areas. MethodsThe target sample comprised randomly selected people living near the border, aged 15-49. To gather information, we utilised: (i) a standardised questionnaire (n=86; 42 men and 44 women) previously used in national household surveys conducted by the Tanzanian government;(ii) focus group discussions (ten male groups, n=47; ten female groups, n=51); and (iii) semistructured interviews with service providers (n=37). ResultsThe mean number of sexual partners, frequency of multiple concurrent partnerships and engagement in transactional sex were significantly higher in the border community than in the national population. Knowledge about HIV was comparable with that in the general population.Access to SRH services was limited in the border areas. ConclusionEfforts to reduce HIV transmission and to improve SRH in the border areas should focus on gaps in service delivery rather than education and information activities alone. In addition, multi-sectorial efforts spanning the health, social, legal and private sectors addressing gender imbalances and poverty alleviation are imperative for reducing poverty-driven unsafe transactional sex.3

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Prevalence and risk factors of human papillomavirus infection by penile site in uncircumcised Kenyan men

Smith

Backes

Hudgens

et al. 2009

Intl Journal of Cancer

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Human papillomavirus (HPV) prevalence was estimated from 2,705 sexually active, uncircumcised, human immunodeficiency virus seronegative men aged 17-28 years in Kisumu, Kenya. HPV prevalence was 51.1% (95% confidence interval: 49.2-53.0%) in penile cells from the glans/coronal sulcus and/or shaft. HPV prevalence varied by anatomical site, with 46.5% positivity in the glans/coronal sulcus compared with 19.1% in the shaft (p < 0.0001). High-risk HPV was detected in 31.2% of glans and 12.3% of shaft samples (p < 0.0001). HPV16 was the most common type and 29.2% of men were infected with more than one HPV type. Risk factors for HPV infection included presence of C. trachomatis, N. gonorrhea, self-reported sexually transmitted infections, and less frequent bathing. Lifetime number of sexual partners and herpes simplex virus type-2 seropositivity were also marginally associated with HPV infection.Human papillomavirus (HPV) infection is the main cause of invasive cervical cancer (ICC) in women, and an important cause of vaginal, vulvar and anal cancer in women as well as anal and penile cancer in men. Given that men are important in transmitting infection to their female partners, understanding factors associated with HPV infections in men are important for control of HPV infection in both men and women. HPV prevalence data in men are limited, especially from Africa, despite ICC being the most common female cancer in this region.1 Type-specific data in men are needed to improve understanding of factors associated with male HPV infection and the role of penile high-risk HPV (i.e., oncogenic) types in transmission to female partners.Few data are available comparing HPV type-distribution from different anatomical sites in men.2,3 Although risk factors for penile HPV infections in men have been reported, 4 data remain unreported on associations between penile HPV infection and laboratory-diagnosed sexually transmitted infections (STIs) including C. trachomatis and N. gonorrhea.We previously reported penile HPV prevalence in three anatomical sites (shaft; glans/coronal sulcus; and urethra) from 98 men in Kisumu, Kenya.5 Here we assess type-specific HPV prevalence by anatomical site and estimate risk factors for prevalent HPV infection in over 2,700 young sexually active, uncircumcised men in Kenya, including the 98 men reported on previously. Material and Methods Study Population and EnrollmentUncircumcised men aged 17-28 years were screened between February 4, 2002 and September 6, 2005 in Kisumu, Kenya to participate in a randomized controlled trial (RCT) of male circumcision. 6 The primary aim of the RCT was to determine the effectiveness of male circumcision in reducing human immunodeficiency virus (HIV) incidence. In brief, inclusion criteria included being uncircumcised, HIV seronegative, sexually active, and having hemoglobin of 9.0 g/100 mL. Study

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Epidemiology of human papillomavirus infection among fishermen along Lake Victoria Shore in the Kisumu District, Kenya

Cited by 37 publications

References 28 publications

Human papillomavirus infection and disease in men: Impact of HIV

Human papillomavirus infection and disease in men: Impact of HIV

Sexual and reproductive health and HIV in border districts affected by migration and poverty in Tanzania

Prevalence and risk factors of human papillomavirus infection by penile site in uncircumcised Kenyan men

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