Epidemiology of multidrug resistant bacterial organisms and Clostridium difficile in German hospitals in 2014: Results from a nationwide one-day point prevalence of 329 German hospitals

Abstract

BackgroundOne important aspect in combatting resistance to antibiotics is to increase the awareness and knowledge by epidemiological studies. We therefore conducted a German-wide point-prevalence survey for multidrug resistant bacterial organisms (MDROs) and Clostridium difficile (CD) to assess the epidemiology and structure quality of infection control in German hospitals.Method1550 hospitals were asked to participate and to report surveillance data on the prevalence of Methicillin-resistant and Vancomycin resistant Staphylococcus aureus (MRSA, VRSA/GRSA), Vancomycin resistant Enterococcus faecalis/faecium (VRE), multiresistant strains of Escherichia coli (EC), Klebsiella spp. (KS), Enterobacter spp. (ES), Acinetobacter spp. (AB) and Pseudomonas spp. (PS). as well as CD infections.ResultsSurveys from 73,983 patients from 329 hospitals were eligible for analysis. MRSA was the most often reported pathogen (prevalence: 1.64 % [CI95: 1.46-1.82]), followed by 3 multidrug resistant EC (3MRGN-EC) (0.75 % [CI95: 0.60–0.89]), CD (0.74 % [CI95: 0.60–0.88]), VRE (0.25 % [CI95: 0.13–0.37]) und 3MRGN-KS (0.22 % [CI95: [0.15–0.29]). The majority of hospitals met the German recommendations for staffing with infection control personnel.ConclusionThe continuing increase in participating hospitals in this third survey in a row indicates a growing awareness to MDROs and our pragmatic approach. Our results confirm that MRSA, 3MRGN-EC, VRE and 3MRGN-KS remain the most prevalent MDROs in German hospitals.

ESKAPE Bacteria and Extended-Spectrum-β-Lactamase-Producing Escherichia coli Isolated from Wastewater and Process Water from German Poultry Slaughterhouses

“…Notable examples are the emergence of (i) extended-spectrum β-lactam (ESBL)-/fluoroquinolone-resistant Enterobacteriaceae (3MDRO) (29, 30) in health-care settings (31) and in the poultry-production chain (19,32), (ii) carbapenem-resistant Enterobacteriaceae in broilers, pigs and meat products (33,34) as well as (iii) ESBLproducing E. coli carrying mobilizable colistin resistance (mcr) genes (35). Emergence of antimicrobial resistances in ESKAPE-bacteria is often attributed with an inappropriate use of antibiotics in human and veterinary medicine (36) on September 30, 2020 by guest http://aem.asm.org/…”

Multiresistente Bakterien bei Patienten in Krankenhäusern und Arztpraxen sowie bei Bewohnern von Altenpflegeheimen in Sachsen – Ergebnisse einer Prävalenzstudie 2017/2018

“…Die MRSA-Prävalenz unter den Krankenhauspatienten lag mit 1,4 % etwas unter den Angaben von Studien der Vorjahre (3,4 bzw. 1,64 % [17,18]), was dem generellen Trend einer sinkenden MRSA-Prävalenz entspricht. Die durchschnittliche VRE-Prävalenz in Krankenhäusern war im Vergleich zu Hübner et al [18] [23].…”

“…1,64 % [17,18]), was dem generellen Trend einer sinkenden MRSA-Prävalenz entspricht. Die durchschnittliche VRE-Prävalenz in Krankenhäusern war im Vergleich zu Hübner et al [18] [23]. In den Studien von Hogardt [7] sowie March et al [24] wurden auch VRE-Prävalenzen nachgewiesen, welche bei 0,4 % -vergleichbar mit dieser Studie -bzw.…”

Antibiotic Resistance Policy and the Stewardship Role of the Nurse

“…Studies involving travel- and region-specific infections have shown that MDROs are found in all regions of the globe (CDC, 2016; Falagas, Karageorgopoulos, Leptidis, & Korbila, 2013; Huebner et al., 2016; Mwanri & AlSaleh, 2014) Studies continue to show that MDRO infections such as methicillin-resistant Staphylococcus aureus (MRSA) are common in Asia, Africa, North America, and South America but are declining in areas with strict antibiotic prescriptive policies such as Europe and Scandinavia (Falagas et al., 2013; Huebner et al., 2016; Theuretzbacher, 2013).…”