Epidemiology of necrotizing infection caused by Staphylococcus aureus and Streptococcus pyogenes at an Iowa hospital

Thapaliya, Dipendra; O’Brien, Ashley; Wardyn, Shylo E.; Smith, Tara C.

doi:10.1016/j.jiph.2015.06.003

Cited by 19 publications

(14 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…It has been an uncommon cause of NF, however, the incidence with Staphylococcus aureus identified as the primary pathogen of monomicrobial NF is on the rise, and community-associated MRSA has emerged as the predominant causative agent in recent years [ 15 – 17 ]. Recent study shows that spa type t008 may be responsible for the increasing incidence of Staphylococcus aureus NF infections [ 18 ].…”

Section: Discussionmentioning

confidence: 99%

Necrotizing soft tissue infection: clinical characteristics and outcomes at a reconstructive center in Jilin Province

et al. 2017

View full text Add to dashboard Cite

BackgroundTo investigate the clinical characteristics and treatment outcomes in necrotizing fasciitis (NF) patients in a reconstructive unit in northeastern China.MethodsMedical records of patients diagnosed with and treated for NF in the extremities from November 2013 to December 2016 were retrospectively reviewed. Demographic data, clinical presentation, duration of signs and symptoms, location of infection, predisposing factors, causative microbiological organisms, laboratory risk indicator for necrotizing fasciitis (LRINEC) score, number of surgical debridements, length of hospital stay, treatments, and outcomes were recorded.ResultsA total of 39 consecutive patients were treated for severe NF (32 male and 7 female). Diabetes mellitus and blunt trauma were the most common risk factors (13 and 9 cases, respectively). The positive predictive value of the LRINEC score in NF diagnosis was 46.2%. Mean duration of signs and symptoms was 4.6 days. Staphylococcus aureus was the most commonly isolated bacteria (20 cases). All patients underwent their first debridement within 12 h of presentation (mean, 4.6 h). Mean number of surgical treatments was 2.8 (range, 2–5) per patient, including debridements. All patients survived, and mean length of hospital stay was 30.81 (range, 21–43) days. Three patients underwent limb amputation.ConclusionsIn our clinical experience, early detection and aggressive debridement are the cornerstones of NF treatment. Antibiotic therapy and intensive care support is essential in severe cases of NF. Anaerobic tissue culture and frozen section biopsy could be adopted as routine tests for diagnosis and decision-making in NF. These findings should inform clinical decisions about the treatment of individual patients with NF.

show abstract

Section: Discussionmentioning

confidence: 99%

Necrotizing soft tissue infection: clinical characteristics and outcomes at a reconstructive center in Jilin Province

et al. 2017

View full text Add to dashboard Cite

show abstract

“…NF is a rapidly progressive and potentially fatal soft-tissue infection. Cervicofacial NF occurs at an exceedingly rare rate, affecting just 1 in 500 000 people, and accounts for only 1%–4% of reported NF cases 1. Given its aggressive nature, early diagnosis and prompt surgical debridement are of consummate importance in successful management of this infection.…”

Section: Discussionmentioning

confidence: 99%

Cervicofacial necrotising fasciitis by clindamycin-resistant and methicillin-resistantStaphylococcus aureus(MRSA) in a young healthy man

Ran¹,

Hicks

Alexiev

et al. 2018

BMJ Case Rep

View full text Add to dashboard Cite

An otherwise healthy 24-year-old man presented with 1 week of fever, facial pain and swelling. He initially sought care at an outside hospital, where he was diagnosed with folliculitis and sent home with oral antibiotics. On arrival at our institution, CT neck was ordered, which demonstrated diffuse submental phlegmon, prompting incision and drainage. After initial improvement, the patient experienced high fevers and increased swelling just 12 hours later. The decision was made to take the patient for operative exploration, and wide debridement was performed due to suspicion for necrotising fasciitis intraoperatively that was ultimately confirmed on final pathology. Final speciation of intraoperative culture demonstrated a clindamycin-resistant and methicillin-resistant strain of Staphylococcus aureus. The patient was managed with intravenous antibiotics, additional debridement and careful wound care. Delayed partial closure of wound was eventually performed once patient showed marked and persistent clinical improvement. The patient was discharged on hospital day 12 with close follow-up.

show abstract

“…The methicillin resistant strains of S. aureus were identified shortly after the introduction of methicillin in the clinical practice. In hospitals, the MRSA infections are a particular problem (Cooper et al, 1999;MarMartínez-Aguilar et al, 2004;Thapaliya et al, 2015;Mamishi et al, 2015). In 1997, approximately 25% of the nosocomial isolates of S. aureus were methicillin-resistant (Chini et al, 2006; Characterisation of different types of honey Baker et al, 2015).…”

Section: Discussionmentioning

confidence: 99%

Physico-chemical characterization and antibacterial activity of different types of honey tested on strains isolated from hospitalized patients

Junie

Vică

Glevitzky

et al. 2016

Journal of Apicultural Science

View full text Add to dashboard Cite

A b s t r a c tThe first aim of the study was to compare the antibacterial activity of several types of honey of different origins, against some bacterial resistant strains. The strains had been isolated from patients. The second aim was to discover the correlations between the antibacterial character of honey and the physico-chemical properties of the honey. Ten honey samples (polyfloral, linden, acacia, manna, and sunflower) from the centre of Romania were tested to determine their antibacterial properties against the following bacterial species: Pseudomonas aeruginosa, Escherichia coli, Staphylococcus aureus, Staphylococcus epidermidis, Salmonella enterica serovar Typhimurium, Bacillus cereus, Bacillus subtilis, and Listeria monocytogenes. Bacterial cultures in nutrient broth and the culture medium Mueller-Hinton agar were used. The susceptibility to antibiotics was performed using the disk diffusion method. All honey samples showed antibacterial activity on the isolated bacterial strains, in particular polyfloral (inhibition zone 13-21 mm in diameter) -because it is the source of several plants, and manna (inhibition zone 13-19.5 mm in diameter), and sunflower (inhibition zone 14-18.5 mm in diameter). Pure honey has a significant antibacterial activity against some bacteria which are resistant to antibiotics. Bacterial strains differed in their sensitivity to honeys. Pseudomonas aeruginosa and Staphylococcus aureus were the most sensitive. The present study revealed that honey antibacterial activity depends on the origin of the honey. We also found that there was a significant correlation between antibacterial activity of honeys and the colour of the honey but not between acidity and pH. The statistical analysis showed that the honey type influences the antibacterial activity (diameter of the bacterial strains inhibition zones).

show abstract

Epidemiology of necrotizing infection caused by Staphylococcus aureus and Streptococcus pyogenes at an Iowa hospital

Cited by 19 publications

References 26 publications

Necrotizing soft tissue infection: clinical characteristics and outcomes at a reconstructive center in Jilin Province

Necrotizing soft tissue infection: clinical characteristics and outcomes at a reconstructive center in Jilin Province

Cervicofacial necrotising fasciitis by clindamycin-resistant and methicillin-resistantStaphylococcus aureus(MRSA) in a young healthy man

Physico-chemical characterization and antibacterial activity of different types of honey tested on strains isolated from hospitalized patients

Contact Info

Product

Resources

About