Epidemiology of Nontuberculous Mycobacterial Infection, South Korea, 2007–2016

Lee, Hyewon; Myung, Woojae; Koh, Won‐Jung; Moon, Sucbei; Jhun, Byung Woo

doi:10.3201/eid2503.181597

Cited by 133 publications

(96 citation statements)

References 15 publications

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“…In this retrospective study, M. intracellulare (65/193, 33.7%) was the most commonly detected species in respiratory tract samples, followed by M. chelonae / M. abscessus (37/193, 19.2%), M. avium (27/193, 14.0%), M. gordonae (24/193, 12.4%). So in this study, MAC (92/193, 47.7%) was still the most common NTM pathogen in respiratory tract, which is consistent with previous findings in Europe, US, Canada, Australia, Japan, Korea, Southern China and so on (18)(19)(20)(21)(22)(23). Although MAC is the most common pathogen in NTM pulmonary disease, its relative frequency varies widely among different geographical regions.…”

Section: Ntm Species Distribution From Different Specimen Typessupporting

confidence: 91%

Prevalence of Nontuberculous Mycobacteria in a Tertiary Hospital in Beijing, China, January 2013 to December 2018

Huang

Zhao

et al. 2020

Preprint

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Background To investigate the species distribution of non-tuberculous mycobacteria (NTM) among tuberculosis (TB) specimens collected from January 2013 to December 2018 at Peking Union Medical Hospital (Beijing), China. NTM species identification was carried out by DNA microarray chip. Results Mycobacterial species were detected in 1514 specimens from 1508 patients, among which NTM accounted for 37.3% (565/1514), increasing from a proportion of 15.6% in 2013 to 46.1% in 2018 ( P <0.001). Among the 565 NTM positive specimens, the majority (55.2%) were from female patients. Furthermore, patients aged 45-65 years accounted for 49.6% of the total patients tested. Among 223 NTM positive specimens characterized further, the majority (86.2%) were from respiratory tract, whilst 3.6% and 3.1% were from lymph nodes and pus, respectively. Mycobacterium intracellulare (31.8%) and Mycobacterium chelonae / Mycobacterium abscessus (21.5%) were the most frequently detected species, followed by M. avium (13.5%), M. gordonae (11.7%), M. kansasii (7.6%), and others. Conclusion The proportion of NTM among mycobacterial species detected in a tertiary hospital in Beijing, China, increased rapidly from year 2013 to 2018. Middle-aged patients are more likely to be infected with NTM, especially females. Mycobacterium intracellulare and Mycobacterium chelonae / Mycobacterium abscessus were the most frequently detected NTM pathogens. Accurate and timely identification of NTM is important for diagnosis and treatment.

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Section: Ntm Species Distribution From Different Specimen Typessupporting

confidence: 91%

Prevalence of Nontuberculous Mycobacteria in a Tertiary Hospital in Beijing, China, January 2013 to December 2018

Huang

Zhao

et al. 2020

Preprint

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“…However, in other studies including our study, no significant difference of distribution was found between genders 2,10 , and the prevalence of NTM in younger individuals should also be given attention 6 . The difference of prevalence between genders may be due to the heterogenicity of the infection-causing microorganism among different regions 2 or the distribution of ages between genders 19 . In our study, female patients with NTM showed a significantly higher percentage of bronchiectasis than male patients, similar to the results reported by Zhang et al in Singapore 10 .…”

Section: Discussionmentioning

confidence: 99%

Retrospective analysis of patients with non-tuberculous mycobacteria from a primary hospital in Southeast China

Sun

et al. 2020

Sci Rep

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to achieve a comprehensive understanding of the characteristics of patients with non-tuberculous mycobacteria (NTM), patients with NTM between January 2016 and June 2019 were recruited from a primary hospital. NTM were identified based on the MBP64 protein assay. The clinical records and laboratory assay results were retrospectively reviewed. A total of 204 patients with NTM were included in the final analysis. The patients with multiple isolations were more likely accompanied with chronic obstructive pulmonary disease (copD) (p = 0.029) and arthritis (p = 0.049), but showed a lower percentage of positive t-spot results (p = 0.022). In addition, patients with multiple isolations showed a higher rate of positive acid-fast staining results and their symptom duration was more likely longer than 30 days (p = 0.019). Patients with a positive response in T-spot assay showed a higher proportion of nodular manifestation on computed tomography (ct) than those with a negative response. compared with male patients with ntM, female patients showed lower rates of positive acid-fast staining results (p = 0.03), but were more likely accompanied with COPD (p < 0.0001). The positive acid-fast staining results were closely associated with pulmonary cavities and tuberculosis antibody. patients with different NTM isolation frequencies were closely associated with coexisting diseases and examination results.

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“…Infections caused by nontuberculous mycobacteria (NTM) have increased dramatically worldwide in recent years. [1][2][3][4] Mycobacterium abscessus is one of the most common NTM detected. M. abscessus infections are difficult to manage because M. abscessus is intrinsically resistant to a variety of antimicrobials currently available in clinical practice; infections that are refractory to antibiotic therapy frequently result in morbidity and mortality.…”

Section: Introductionmentioning

confidence: 99%

<p>Efflux Pumps Contribute to Intrinsic Clarithromycin Resistance in Clinical, <em>Mycobacterium abscessus</em> Isolates</p>

Guo

Chen

Zhang

et al. 2020

IDR

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The emergence of clarithromycin resistance is a challenge in treating Mycobacterium abscessus infections. Known mechanisms that contribute to intrinsic clarithromycin resistance focus on rrl gene-related mutations, but resistant clinical isolates often exhibit an inconsistent rrl genotype. Patients and Methods: In this study, 194 clinical Mycobacterium abscessus isolates were collected from patients with lung infections and the whole genome of each isolate was sequenced. A comprehensive examination of the molecular mechanisms underlying intrinsic clarithromycin resistance was performed, combining MIC determination, comparative genome sequence analysis and qRT-PCR. Results: Of the 194 isolates, 13 (6.7%) were clarithromycin resistant; only seven of these harbored a rrl 2270/2271 mutation. The remaining six resistant isolates did not exhibit a specific resistance-associated mutation in the clarithromycin target-site genes, rrl, rplC, rplD and rplV, or in the rrl modification gene erm(41). qRT-PCR analysis showed that the increased expression of the efflux pump genes, MAB_2355c, MAB_1409c and MAB_1846, as well as their positive regulatory gene whiB7, consistently correlated with increased clarithromycin resistance. The presence of efflux pump inhibitors significantly decreased the MIC of clarithromycin for nonsusceptible isolates, especially the intrinsic resistant isolates that exhibited no rrl 2270/2271 mutation. Conclusion: These findings indicate that efflux pumps play a prominent role in the intrinsic resistance of M. abscessus to clarithromycin, complementing other known resistance mechanisms.

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Epidemiology of Nontuberculous Mycobacterial Infection, South Korea, 2007–2016

Cited by 133 publications

References 15 publications

Prevalence of Nontuberculous Mycobacteria in a Tertiary Hospital in Beijing, China, January 2013 to December 2018

Prevalence of Nontuberculous Mycobacteria in a Tertiary Hospital in Beijing, China, January 2013 to December 2018

Retrospective analysis of patients with non-tuberculous mycobacteria from a primary hospital in Southeast China

<p>Efflux Pumps Contribute to Intrinsic Clarithromycin Resistance in Clinical, <em>Mycobacterium abscessus</em> Isolates</p>

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