Epidemiology of paediatric severe sepsis and septic shock in Turkey: Prevalence, results and treatments study

Abstract

Sepsis, defined as an infection with irregular host response that causes life-threatening organ dysfunction, continues to have a high potential for morbidity and mortality in children. 1 Paediatric sepsis is the most common cause of paediatric death worldwide and results in an estimated 7.5 million deaths per year. 2,3 Severe paediatric sepsis is a life-threatening condition that is widely monitored and treated in paediatric intensive care units (PICUs) worldwide. [2][3][4] Severe sepsis is defined as infection plus infection-induced organ dysfunction; in children, it is characterised by the presence of sepsis and cardiovascular or respiratory dysfunction or dysfunction in two or more organs (neurological, hepatic, hematologic or renal). The prevalence of severe sepsis in PICUs has been reported to be between 2% and 3% in developed countries 5,6 and between 18% and 46% in developing countries. 7,8 In a study conducted in southwest China, the mortality

Primary Immunodeficiency Disorders in Pediatric Intensive Care

“…In one study, it was reported that 23% of patients with inborn errors of immunity followed in the pediatric intensive care unit died due to sepsis and septic shock. [5] In our study, the case group had a mean (SD) PRISM score of 8.3 (5.09), and the PRISM predictive death rate was 3.7%. However, 18 cases (58%) in the case group did not survive to discharge.…”

“…Case reports have demonstrated that life-threatening infections in childhood can be the initial presentation of IEI. [5] However, there is limited knowledge regarding the prevalence of genetic variants of IEIs in patients with sepsis, and guidance is absent on genetic or immunological investigations following the rst episode of sepsis.…”

Bacterial Profile and Antimicrobial Susceptibility Pattern in Septicemia Suspected Children and Available Treatment Options

“…13,14,15 Similar results were reported from another study conducted in Turkey, with 8% sepsis in pediatric patients. 16 On the other hand, these cases were reported with a low ratio in developed and advanced countries, like 2-3%. This variation is related to socio-demographic factors and advanced healthcare 69.35% sepsis rate in neonates.…”