Epidemiology of Parkinson disease in the city of Kolkata, India

Das, Shyamal Kumar; Misra, Amar Kumar; Ray, Biman Kanti; Hazra, Avijit; Ghosal, Malay Kumar; Chaudhuri, Arijit; Roy, Trishit; Banerjee, Tapas Kumar; Raut, Deepak

doi:10.1212/wnl.0b013e3181f735a7

Cited by 68 publications

(45 citation statements)

References 36 publications

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“…The incidence rate and prevalence of Parkinson's disease in India are comparatively lower than in Western and North American countries [4,8] . However, in recent times, due to increased availability of neurological services in the rural areas and changes in demographic patterns, with increased life expectancy, greater numbers of Parkinson's disease cases are being detected in India.…”

Section: Discussionmentioning

confidence: 87%

“…The incidence of Parkinson's disease among Asians is one third to one half that of whites [3] . In India, the prevalence rate and annual incidence rate of the disease are 52.85/100,000 and 5.71/100,000 per year, respectively, which are much lower than those of Western and North American countries [4] . However, in recent times a trend of increased occurrence has been observed in India due to changes in demographic patterns, with increased lifespan and a larger aged population in India [4] .…”

Section: Introductionmentioning

confidence: 83%

“…In India, the prevalence rate and annual incidence rate of the disease are 52.85/100,000 and 5.71/100,000 per year, respectively, which are much lower than those of Western and North American countries [4] . However, in recent times a trend of increased occurrence has been observed in India due to changes in demographic patterns, with increased lifespan and a larger aged population in India [4] . Beside this, infection, exposure to toxins and heavy metals, lifestyle and heredity have all been supposed to play an important role in the development of Parkinson's disease [5] .…”

Section: Introductionmentioning

confidence: 83%

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Role of Familial, Environmental and Occupational Factors in the Development of Parkinson’s Disease

Das¹,

Ghosh²,

Nag³

et al. 2011

Neurodegener Dis

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Background: Despite intensive research during the past several decades, the cause of Parkinson’s disease remains unknown. Infections, toxins, lifestyle and hereditary factors have all been supposed to play a role in the genesis of Parkinson’s disease. The final mechanisms of neuronal injury and death are probably similar, where both genetic and environmental factors are important, and these two factors interact along the etiopathogenic pathway. Objective: The purpose of the present study is to evaluate the role of familial, environmental and occupational factors in the development of Parkinson’s disease. Methods: We evaluated 345 cases of idiopathic Parkinson’s disease (215 males, 130 females; mean age 62 ± 2 years) and 370 controls (220 males, 150 females; mean age 62 ± 3 years) between January 2003 and January 2008 with regard to the following aspects in detail: place of living, family history of Parkinson’s disease and tremor, source of drinking water, exposure to insecticides, pesticides, herbicides and industrial toxins, acute poisoning, CNS infections and head injury. The duration of exposure to the risk factors and the history of Parkinson’s disease among the cases were investigated after obtaining written informed consent from cases and controls. Results and Conclusions: Family history of Parkinson’s disease and familial tremor (p = 0.035), exposure to insecticides and pesticides (p = 0.049), well water use for drinking purposes (p = 0.03), Japanese B encephalitis (p = 0.04) and acute organophosphate poisoning (p = 0.046) were associated with the development of Parkinson’s disease in this region of India. Further research is needed at the epidemiological, genetic and molecular levels for a better understanding of the etiopathogenesis of Parkinson’s disease as well as remedial aspects.

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Section: Discussionmentioning

confidence: 87%

Section: Introductionmentioning

confidence: 83%

Section: Introductionmentioning

confidence: 83%

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Role of Familial, Environmental and Occupational Factors in the Development of Parkinson’s Disease

Das¹,

Ghosh²,

Nag³

et al. 2011

Neurodegener Dis

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“…The cardinal symptoms of PD are hypokinesia, tremors, postural imbalances and gait deficits. Pathological signs are most common among individuals who are between the ages of 50 and 60 [39], but symptoms may appear during a number of stages of life. In addition to the aforementioned motor impairments, behavioral, cognitive and other functional changes can be observed at different stages of PD.…”

Section: Mental Disorders and Neurodegenerative Disordersmentioning

confidence: 99%

Neuroscience of Exercise: From Neurobiology Mechanisms to Mental Health

Portugal¹,

Cevada²,

et al. 2013

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The neuroscience of exercise is a growing research area that is dedicated to furthering our understanding of the effects that exercise has on mental health and athletic performance. The present study examined three specific topics: (1) the relationship between exercise and mental disorders (e.g. major depressive disorder, dementia and Parkinson's disease), (2) the effects of exercise on the mood and mental health of athletes, and (3) the possible neurobiological mechanisms that mediate the effects of exercise. Positive responses to regular physical exercise, such as enhanced functional capacity, increased autonomy and improved self-esteem, are frequently described in the recent literature, and these responses are all good reasons for recommending regular exercise. In addition, physical exercise may improve both mood and adherence to an exercise program in healthy individuals and might modulate both the performance and mental health of athletes. Exercise is associated with the increased synthesis and release of both neurotransmitters and neurotrophic factors, and these increases may be associated with neurogenesis, angiogenesis and neuroplasticity. This review is a call-to-action that urges researchers to consider the importance of understanding the neuroscience of physical exercise and its contributions to sports science.

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“…In India, the prevalence rate of PD has been reported to be 53 per 100,000 [6]. Among the causal genes, Parkin harbors the highest number of mutations.…”

Section: Introductionmentioning

confidence: 99%

DJ-1Variants in Indian Parkinson’s Disease Patients

Sadhukhan

Biswas²,

Das³

et al. 2012

Disease Markers

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Abstract. Parkinson's disease (PD) is a common neurodegenerative movement disorder. Among the candidate genes, DJ-1 accounts for about 1% of the cases in different populations. We aim to find the contribution of the gene towards PD among Indians. By screening DJ-1 in 308 PD patients of eastern India and 248 ethnically matched controls, a total of 21 nucleotide variantsincluding two nonsynonymous changes -were detected. p.Arg98Gln was identified in 6 unrelated patients and 2 controls while p.Val35Ile, a novel change, was found only in 2 unrelated patients. A SNP (rs7517357) was observed to be moderately associated with increased risk of PD (p < 0.05). The deletion allele (g.168 185del) of a known 18 bp del/ins/dup polymorphism was found to be over represented (p < 0.05) among older patients (> 40 years) compared to the controls (> 45 years). Two of the patients, also heterozygotes for PINK1 mutation, had more severe disease phenotypes, consistent with the reported interaction between PINK1 and DJ-1 gene products [19]. Our results demonstrate that up to 3.9% (12/308) of PD patients of eastern India harbor DJ-1 variants that should be explored further for any causal relationship with PD.

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Epidemiology of Parkinson disease in the city of Kolkata, India

Abstract: This study documented lower prevalence and incidence of PD as compared with Caucasian and a few Oriental populations. The mortality rates were comparable. The decreased age-specific PR among slum populations and higher relative risk of death need further probing.

Cited by 68 publications

References 36 publications

Role of Familial, Environmental and Occupational Factors in the Development of Parkinson’s Disease

Role of Familial, Environmental and Occupational Factors in the Development of Parkinson’s Disease

Neuroscience of Exercise: From Neurobiology Mechanisms to Mental Health

DJ-1Variants in Indian Parkinson’s Disease Patients

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