Epidemiology of Pediatric Acute Pancreatitis in Taiwan

Abstract

Objective:Pediatric acute pancreatitis (AP) may be different from adult AP in various respects. This study focuses on the epidemiology and medical resource use of pediatric AP in Taiwan.Methods:Patients aged 0 to 18 years with AP were identified from the Taiwan National Health Insurance Research Database based on the International Classification of Diseases, Ninth Revision code of AP 577.0. The medical resource use was measured by length of hospital stay and hospital charges.Results:Between 2000 and 2013, a total of 2127 inpatient cases of pediatric AP were collected, which represented a hospitalization rate of 2.83 per 100,000 population. The incidence by age had 2 peaks, the first peak was at age 4 to 5 years old, and the second one started rising from 12 to 13 years old until adulthood. The incidence by year increased from 2.33 to 3.07 cases per 100,000 population during the study period. The average hospital stay is steady, but the medical cost is increasing. Girls have longer hospital stays, higher medical expenditures, more use of endoscopic retrograde cholangiopancreatography possibly due to more comorbidities with biliary tract diseases than boys (P < 0.05). The mortality in cases of AP is mostly associated with systemic diseases rather than AP itself.Conclusions:The incidence of pediatric AP in Taiwan is in a rising trend. There are gender differences in length of hospital stay, medical costs, use of endoscopic retrograde cholangiopancreatography and comorbidities.

Global Incidence of Acute Pancreatitis Is Increasing Over Time: A Systematic Review and Meta-Analysis

“…Although incidence of all 10 overlapping studies were reported alongside all other studies in the tables, only 4 were included in the meta-analyses and figures. 3,[30][31][32] In total, 44 studies, from the following regions, met our inclusion criteria: Europe (n ¼ 24 10,12,13, ), North America (n ¼ 11 3,4,9,[27][28][29][30][31][53][54][55] ), South America (n ¼ 1 56 ), Asia (n ¼ 5 [57][58][59][60][61] ), and Oceania (n ¼ 3 [62][63][64] ). The 4 studies reporting the incidence of acute pancreatitis in children exclusively were North America (n ¼ 2 54,55 ), Asia (n ¼ 1 57 ), and Oceania (n ¼ 1 63 ).…”

“…3,[30][31][32] In total, 44 studies, from the following regions, met our inclusion criteria: Europe (n ¼ 24 10,12,13, ), North America (n ¼ 11 3,4,9,[27][28][29][30][31][53][54][55] ), South America (n ¼ 1 56 ), Asia (n ¼ 5 [57][58][59][60][61] ), and Oceania (n ¼ 3 [62][63][64] ). The 4 studies reporting the incidence of acute pancreatitis in children exclusively were North America (n ¼ 2 54,55 ), Asia (n ¼ 1 57 ), and Oceania (n ¼ 1 63 ). Details of each study are provided in an article descriptors table (Supplementary Table 3): country and region, population representativeness, study period, first presentation or first and recurrent presentations of acute pancreatitis, context of pancreatitis data gathered (eg, admission, discharge, or emergency), diagnosis method (ie, ICD codes and chart review), and etiology of acute pancreatitis.…”

Imaging of Pancreatitis in Children

“…[1][2][3][4][5] Pancreatitis has been reported in all pediatric age groups with no significant sex differences in any of the age groups. 1,3,4 The INSPPIRE (INternational Study Group of Pediatric Pancreatitis: In Search for a CuRE) Group has categorized AP, acute recurrent pancreatitis (ARP), and chronic pancreatitis (CP) based on the natural history of the disease. 6,7 Studies have reported that 12.2-34.5% of children with AP have recurrence of the disease.…”

Risk factors of recurrent acute pancreatitis after conservative treatment in pediatric population: a single-center study

“…Pediatric AP has increased in incidence to the current estimate of 3.6-13.2/100 000 1 in the last two decades. [2][3][4] Its etiology is quite different from that of adults. 5 Gallstones, medications, idiopathic and systemic illness are the most common causes of pediatric AP.…”