Epidemiology of Restless Legs Symptoms in Adults

Phillips, Barbara; Young, Terry; Finn, Laurel; Asher, Karen; Hening, Wayne A.; Purvis, Cheryl

doi:10.1001/archinte.160.14.2137

Cited by 685 publications

(477 citation statements)

References 15 publications

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“…Previous population-based studies found an increasing prevalence of RLS with age 11 , and controversial results about gender 11,13 . Unlike primary RLS, it seems that age and gender are not important factors for the development of RLS in CRF subjects.…”

Section: Discussionmentioning

confidence: 86%

“…Data in population-based studies 11,13 about correlation between RLS and smoking was controversial. Many of our patients might have felt ashamed or frightened when asked about smoking habits, so we cannot attest the reliability of our results.…”

Section: Discussionmentioning

confidence: 99%

“…Although electrophysiologic studies of median, ulnar and sural nerves have not shown a correlation with RLS in CRF patients 9 , isolated small sensory fiber loss, undetectable in routine nerve conduction studies, could be an interesting theoretical possibility in this setting, at least for some patients 10 . In RLS patients without CRF, an association between diabetes and RLS is reported 11 . Such a relationship was not found in CRF patients 1 , and there are no other data indicating a link between the presence of RLS and comorbidities or the etiology of renal disease in these subjects.…”

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confidence: 99%

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Restless legs syndrome in patients on chronic hemodialysis in a Brazilian city: frequency, biochemical findings and comorbidities

Filho

Gorini

Purysko

et al. 2003

Arq. Neuro-Psiquiatr.

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-Objective: To evaluate the frequency of restless legs syndrome (RLS) in patients with chronic renal failure (CRF) in Petrópolis, Brazil, and investigate associations between the syndrome and: demographic characteristics, biochemical variables and comorbidities. Method: A cross-sectional study in which we interviewed 176 patients on dialytic therapy based on criteria elaborated by the International Restless Legs Syndrome Study Group, and compared data of patients with and without RLS. Results: The frequency was 14.8 %. There were no significant differences between the two groups in demographic and biochemical variables investigated (iron, creatinine, intact parathyroid hormone, hemoglobin, calcium, phosphate). We found no association between RLS and the most common comorbidities, except for chronic glomerulonephritis (CGN) (OR = 3.84, p < 0.01). Conclusion: In the studied population RLS is a common disorder, and is not associated with the investigated biochemical abnormalities. A higher frequency of RLS in subjects with CGN is a finding that needs further investigation.KEY WORDS: restless legs syndrome, chronic renal failure, chronic glomerulonephritis.Síndrome das pernas inquietas em pacientes em programa de hemodiálise em P índrome das pernas inquietas em pacientes em programa de hemodiálise em P índrome das pernas inquietas em pacientes em programa de hemodiálise em P índrome das pernas inquietas em pacientes em programa de hemodiálise em P índrome das pernas inquietas em pacientes em programa de hemodiálise em Petrópolis, RJ: frequência, etrópolis, RJ: frequência, etrópolis, RJ: frequência, etrópolis, RJ: frequência, etrópolis, RJ: frequência, aspectos laboratoriais e comorbidades. aspectos laboratoriais e comorbidades. aspectos laboratoriais e comorbidades. aspectos laboratoriais e comorbidades. aspectos laboratoriais e comorbidades. RESUMO -Objetivo: Determinar a frequência de síndrome das pernas inquietas (SPI) em pacientes com insuficiência renal crônica (IRC) em Petrópolis, Brasil, e investigar associação entre a síndrome e: dados demográficos, achados bioquímicos e comorbidades. Método: Estudo transversal no qual entrevistamos 176 pacientes em terapia dialítica a partir de critérios definidos pelo International Restless Legs Syndrome Study Group, e comparamos dados de pacientes com e sem SPI. Resultado: A frequência foi 14,8 %. Não houve diferença significativa entre os 2 grupos nas variáveis demográficas e bioquímicas (ferro, cretinina, paratormônio, hemoglobina, cálcio, fósforo) investigadas. Não houve associação entre SPI e as principais comorbidades, exceto glomerulonefrite crônica (GNC) (OR = 3,84, p < 0,01). Conclusão: SPI é condição comum na população estudada, e não é associada com as alterações bioquímicas investigadas. O achado de maior frequência de SPI em pacientes com GNC merece investigações mais detalhadas. The frequency of restless legs syndrome (RLS) is higher in patients with end-stage renal disease than in the general population, and previous studies have reported it to vary...

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Section: Discussionmentioning

confidence: 86%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

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Restless legs syndrome in patients on chronic hemodialysis in a Brazilian city: frequency, biochemical findings and comorbidities

Filho

Gorini

Purysko

et al. 2003

Arq. Neuro-Psiquiatr.

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“…Lifestyle factors such as lack of physical activity, obesity, cigarette smoking, alcohol intake, and consumption of coffee have also been postulated to have an effect on the risk or severity of RLS. 13 However, the evidence linking these factors to RLS is based on small studies (n = 41), 16 and the use of different methodologic and diagnostic criteria, and the lack of control for covariates, has resulted in conflicting results. We thus prospectively examined the associations between lifestyle factors (i.e., obesity, physical activity, overall diet quality, smoking, and alcohol intake) and risk of developing RLS in two large US cohorts including more than 65,000 men and women.…”

Section: Introductionmentioning

confidence: 99%

Lifestyle factors and risk of restless legs syndrome: Prospective Cohort study

Batool-Anwar

Vito

et al. 2013

Sleep Medicine

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Study Objectives: To examine the association between modifiable lifestyle factors, and the risk of developing restless legs syndrome (RLS). Methods: This is a Prospective Cohort study of population including 12,812 men participating in Health Professionals Follow-up Study and 42,728 women participating in the Nurses' Health study II. The participants were free of RLS at baseline (2002 for the HPFS and 2005 for the NHS II) and free of diabetes and arthritis through follow-up. RLS was assessed via a set of questions recommended by International Restless Legs Syndrome Study group. The Information was collected on height, weight, level of physical activity, dietary intake, and smoking status via questionnaires. Results: During 4-6 years of follow-up, we identified 1,538 incident RLS cases. Participants with normal weight, and who were physically active, non-smoker, and had some alcohol consumption had a lower risk of developing RLS. When we combined the effects of these four factors together, we observed a dose response relationship between the increased number of healthy lifestyle factors and a low risk of RLS: after adjusting for potential confounders the pooled odds ratio was 0.67 (95% CI: 0.47-0.97) for 4 vs.0 healthy factors (p trend < 0.001). In contrast, we did not observe significant associations between caffeine consumption or diet quality as assessed by the Alternate Healthy Eating Index, and altered RLS risk in men and women. I NTRO DUCTI O NRestless legs syndrome (RLS), a debilitating illness that has affected people over the centuries, 1 is characterized by unpleasant sensations and an irresistible urge to move the legs. 2-4 A prevalence of 5% to 15% has been reported in United States and Europe 5-7 with lower prevalence rates (< 5%) in Asian populations. 8 Epidemiologic studies have suggested an association between RLS and cardiovascular diseases, Parkinson disease, erectile dysfunction, poor sleep, and depressive symptoms. 9-11 The burden of RLS on quality of life 12 is comparable to that of other chronic illnesses such as diabetes, arthritis, hypertension, and acute myocardial infarction. 3 The etiology of RLS is not known; however, several pathophysiologic mechanisms have been reported. Age and genetics are important determinants of clinical expression for primary RLS, 13-15 whereas secondary RLS is present in a variety of conditions including iron deficiency, diabetes, renal failure, Parkinson disease, and pregnancy. Lifestyle factors such as lack of physical activity, obesity, cigarette smoking, alcohol intake, and consumption of coffee have also been postulated to have an effect on the risk or severity of RLS. 13 However, the evidence linking these factors to RLS is based on small studies (n = 41), 16 and the use of different methodologic and diagnostic criteria, and the lack of control for covariates, has resulted in conflicting results. We thus prospectively examined the associations between lifestyle factors (i.e., obesity, physical activity, overall diet quality, smoking, and alcohol intake)...

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“…other studies have reported prevalence from 2.5 to 15% and it is highly variable depending on the age and design addressed [17][18][19] . Rothdach et al conducted a study using the same diagnostic criteria and showed a prevalence similar to the one found in our sample, 9.8% 4 .…”

Section: Resultsmentioning

confidence: 99%

086 Restless Legs Syndrome – A Study of Prevalence Among Medical School Faculty Members

Haggstrãm¹,

Bigolin²,

Assoni³

et al. 2009

Sleep Medicine

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-The aim of this study was to assess the prevalence of idiopathic restless legs syndrome (RLS) and its correlations in a sample of Medical School faculty members. A transversal study was conducted at a Medical School in the south of Brazil included 78 faculty members. The subjects answered to a structured questionnaire specific to RLS diagnosis and the Epworth and the Stanford scales to measure daytime sleepiness. Severity of the disease was also evaluated. The variables were analyzed to statistical significance. RLS was diagnosed in 10.25% of the subjects evaluated and most were women (62.5%). The prevalence of daytime sleepiness was significantly greater among the subjects suffering from RLS (p=0.04). RLS subjects were significantly younger than the group without the syndrome (p=0.02). RLS had a considerable prevalence in the sample studied. Daytime sleepiness and young age showed an important correlation to this syndrome, as other potential factors were not confirmed.KEy WoRDS: restless leg syndrome, prevalence, idiopathic, daytime sleepness. síndrome das pernas inquietas: estudo de prevalência entre professores do curso de medicina Resumo -o objetivo deste estudo foi analisar a prevalência da síndrome das pernas inquietas (SPI) e suas implicações clínicas em uma amostra envolvendo docentes de um curso de Medicina. Foi realizado um estudo transversal que envolveu 78 docentes do curso de Medicina de uma Universidade do Sul do Brasil. os indivíduos avaliados responderam um questionário com perguntas epidemiológicas e de diagnóstico para SPI, assim como escalas de sonolência de Epworth e Stanford. os portadores de SPI responderam questionário de gravidade. As variáveis foram analisadas quanto à significância estatística. obtivemos uma prevalência de indivíduos portadores de SPI de 10,25%, sendo 62,5% destes do sexo feminino. A existência de sonolência diurna excessiva foi significativamente maior em pacientes portadores da síndrome (p=0,04). os pacientes portadores de SPI possuíam idade significativamente inferior ao grupo não sindrômico (p=0,02). A SPI mostrou-se bastante prevalente em nossa amostra. A prevalência de sonolência diurna e menos idade mostrou importante relação com esta síndrome, enquanto outros fatores possivelmente relacionados não foram confirmados.PALAvRAS-ChAvE: síndrome das pernas inquietas, prevalência, idiopática, sonolência diurna.

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Epidemiology of Restless Legs Symptoms in Adults

Cited by 685 publications

References 15 publications

Restless legs syndrome in patients on chronic hemodialysis in a Brazilian city: frequency, biochemical findings and comorbidities

Restless legs syndrome in patients on chronic hemodialysis in a Brazilian city: frequency, biochemical findings and comorbidities

Lifestyle factors and risk of restless legs syndrome: Prospective Cohort study

086 Restless Legs Syndrome – A Study of Prevalence Among Medical School Faculty Members

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