Restless legs syndrome in patients on chronic hemodialysis in a Brazilian city: frequency, biochemical findings and comorbidities

Filho, Gilberto Salgado; Gorini, Cláudia C; Purysko, Andrei S.; Silva, Herta C; Elias, Ibrahim Eduardo F

doi:10.1590/s0004-282x2003000500004

Cited by 40 publications

(21 citation statements)

References 18 publications

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“…Correction of anemia and/or iron deficiency may improve RLS symptoms in ESRD patients [1, 2], while iron deficiency [5] and lower Hb [5, 14] are reportedly associated with RLS. This, however, has not been a consistent finding [6, 7,15,16,17]. Similarly, an inadequate dialysis dose was reported to increase the risk of RLS [7], but this has not been confirmed [5, 6,14,15,16,17].…”

Section: Discussionmentioning

confidence: 97%

“…Similarly, an inadequate dialysis dose was reported to increase the risk of RLS [7], but this has not been confirmed [5, 6,14,15,16,17]. Finally, hyperphosphatemia was associated with higher prevalence of RLS in one study [14], but not in several others [6, 7,15,16,17], while lower [17], higher [7] or comparable [15, 16] iPTH levels were reported in RLS ‘positive’ versus ‘negative’ patients. Considering the uncertainties about these factors, and considering that this preliminary study was restricted to a limited population at a single dialysis center, they were not included in the current multivariate analysis but were controlled for by other means.…”

Section: Discussionmentioning

confidence: 99%

“…Under these conditions we found a history of HD, diabetes and exposure to Ca 2+ antagonists each independently associated with a higher prevalence of RLS. A longer history of HD has been reported to increase [6, 15] or not to affect the risk of RLS [7, 16, 17], while diabetes, except for one study [8], is not considered to affect the occurrence or severity of ESRD-related RLS [5,6,7,14,15,16,17]. This discrepancy between the current and published data might be due to patient selection criteria in the present study; when unselected ESRD patients are considered the effects of longer duration of dialysis or diabetes might be difficult to detect.…”

Section: Discussionmentioning

confidence: 99%

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Restless Legs Syndrome in Hemodialysis Patients: Association with Calcium Antagonists

2007

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Uremia-related restless legs syndrome (RLS) is a known form of secondary RLS. This cross-sectional survey included patients (n = 82) on stable hemodialysis (HD; >3 months, Kt/V >1.2) who were iron-replete, free of neurodegenerative or psychiatric disorders, severe polyneuropathy and radiculopathy, not exposed to antipsychotics/antidepressants, and not severely anemic. Forty-nine (60%) were RLS ‘positive’, and 25 (31%) had severe/very severe symptoms (International Restless Legs Syndrome Study Group criteria). None had been diagnosed previously. In a multivariate analysis, the prevalence of RLS was higher in diabetic patients [vs. nondiabetics; prevalence ratio (PR) 2.32, 95% CI 1.50–3.60, p < 0.001] and those exposed to Ca²⁺ antagonists (vs. nonexposed; PR 2.02, CI 1.47–2.76, p < 0.001), and also increased with dialysis duration (PR 1.05, 95% CI 1.02–1.09, p < 0.001). Association of Ca²⁺ antagonists and RLS in uremic patients has not been reported previously and deserves further research.

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Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Restless Legs Syndrome in Hemodialysis Patients: Association with Calcium Antagonists

2007

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“…Besides the loss of inhibition of subcortical movement pattern generators 3 , there probably exists a vesperal increase in the excitability of the spinal motoneurons, reinforcing the final portion of the spinal reflex 4 . The literature has been interested in the prevalence of RLS under special circumstances, such as during renal insufficiency and pregnancy 1,3,5 . More recently, however, special consideration has been given to post-operatory patients, especially those who have undergone major thoracic surgery 6,7 .…”

Section: Discussionmentioning

confidence: 99%

Restless legs syndrome associated with cardiac failure and aggravated after valvular replacement: Vesper's curse?

Rodrigues

Corso

et al. 2008

Arq. Neuro-Psiquiatr.

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“…The prevalence of RLS is estimated to be 5% to 15% in adults and it is more common in women 2,3 , and was firstly reported in Brazil by Mattos Pimenta 4 . RLS may be either idiopathic (primary RLS, which often has a familial component) or secondary, occurring with other medical conditions, particularly iron deficiency anaemia, pregnancy, or end-stage renal disease 5 . The most common pharmacological agents used in clinical practice for the treatment of RLS are levodopa, dopamine agonists, opioids, benzodiazepines and anticonvulsants 1,6 .…”

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confidence: 99%

Anticonvulsants to treat idiopathic restless legs syndrome: systematic review

Conti

Oliveira

Valbuza

et al. 2008

Arq. Neuro-Psiquiatr.

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-Background:Restless legs syndrome (RLS) is a sensory motor disorder characterized by a distressing urge to move the legs and sometimes also other parts of the body usually accompanied by a marked sense of discomfort or pain in the leg or other affected body part. Many treatments have been used to minimize the discomfort of the disease, among them the anticonvulsant therapy. Aim: This review aims to evaluate the efficacy and safety of anticonvulsant treatment for idiopathic RLS. Method: Systematic review of randomized or quasi-randomized, double blind trials on anticonvulsant treatment for RLS. Outcomes: relief of RLS symptoms, subjective and objective sleep quality, quality of life, and adverse events associated with the treatments. Results: A total of 231 patients were randomized in three cross over studies and one parallel study. Three studies with carbamazepine, one with sodium valproate, and one with gabapentin, and they were very heterogeneous so we could not perform a metanalyses. Conclusions: There is no scientific evidence on RLS treatment with anticonvulsants for clinical practice.KEY WORDS: restless legs, anticonvulsant. Anticonvulsivantes para a síndrome das pernas inquietas idiopática: revisão sistemáticaResumo -Contexto: A síndrome das pernas inquietas (SPI ) é uma desordem caracterizada por um impulso de mover as pernas e as vezes outras partes do corpo acompanhado geralmente por desconforto ou da dor nas pernas ou em outra parte afetada. Muitos tratamentos tem sido utilizados para aliviar o desconforto causado pela doença entre eles os anticonvulsivantes. Objetivo: Este estudo objetivou avaliar a eficácia e segurança do tratamento da SPI com as drogas anticonvulsivantes. Método: Revisão sistemática de ensaios clínicos randomizados ou quasi-randomizados, duplo-cegos para o tratamento com anticonvulsivantes para SPI. Desfechos: alívio dos sintomas da SPI, qualidade subjetiva e objetiva do sono, qualidade de vida e efeitos adversos relacionados ao tratamento. Resultados: Um total de 231 pacientes foram randomizados em três estudos cross-over e um estudo paralelo. Três estudos avaliaram a carbamazepina, um estudo avaliou o ácido valpróico e o outro a gabapentina, eles eram muito heterogêneos, o que impossibilitou a metanálise dos resultados. Conclusão: Não existe evidência científica, que o tratamento da SPI com anticonvulsivantes é eficaz e seguro, para a prática clínica.PALAvRAS-chAvE: pernas inquietas, anticonvulsivantes.Universidade Federal de São Paulo, SP, Brazil (UNIFESP):

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Restless legs syndrome in patients on chronic hemodialysis in a Brazilian city: frequency, biochemical findings and comorbidities

Cited by 40 publications

References 18 publications

Restless Legs Syndrome in Hemodialysis Patients: Association with Calcium Antagonists

Restless Legs Syndrome in Hemodialysis Patients: Association with Calcium Antagonists

Restless legs syndrome associated with cardiac failure and aggravated after valvular replacement: Vesper's curse?

Anticonvulsants to treat idiopathic restless legs syndrome: systematic review

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