Epidemiology of restless legs syndrome in French adults

Tison, François; Crochard, Anne; Léger, Damien; Bouée, S.; Lainey, Eric; Hasnaoui, Abdelkader El

doi:10.1212/01.wnl.0000168910.48309.4a

Cited by 296 publications

(213 citation statements)

References 30 publications

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“…The current authors also found a 25% prevalence of restless legs syndrome in CPAP user patients with RES. This is significantly greater than the prevalence reported in the French general population [25]. In clinical cohorts, 30% of restless legs syndrome patients complain of EDS as assessed by an ESS score of .10 [26].…”

Section: Prevalence Of Resmentioning

confidence: 67%

Prevalence of residual excessive sleepiness in CPAP-treated sleep apnoea patients: the French multicentre study

Pépin¹,

Viot-Blanc²,

Escourrou³

et al. 2009

Eur Respir J

172

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The percentage of compliant continuous positive airway pressure (CPAP)-treated apnoeic patients that continue to experience residual excessive sleepiness (RES) is unknown.RES was defined by an Epworth Sleepiness Scale (ESS) score of o11. In total, 502 patients from 37 French sleep centres using CPAP .3 h?night -1 attending their 1-yr follow-up visit were eligible. ESS and polysomnographic data as well as symptoms, quality of life, depression scores and objective CPAP compliance at 1 yr were collected. Overall, 60 patients remained sleepy on CPAP (ESS 14.3¡2.5) leading to a prevalence rate of RES of 12.0% (95% confidence interval (CI) 9.1-14.8). After having excluded associated restless leg syndrome, major depressive disorder and narcolepsy as confounding causes, the final prevalence rate of RES was 6.0% (95% CI 3.9-8.01). Patients with RES were younger and more sleepy at diagnosis. The relative risk of having RES was 5.3 (95% CI 1.6-22.1), when ESS before treatment was o11. Scores of emotional and energy Nottingham Health Profile domains were two times worse in patients with RES.As 230,000 obstructive sleep apnoea patients are currently treated in France by continuous positive airway pressure, more than 13,800 of them might suffer from residual excessive sleepiness.

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Section: Prevalence Of Resmentioning

confidence: 67%

Prevalence of residual excessive sleepiness in CPAP-treated sleep apnoea patients: the French multicentre study

Pépin¹,

Viot-Blanc²,

Escourrou³

et al. 2009

Eur Respir J

172

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“…[3][4][5][6][7][8] RLS is either idiopathic or it occurs in association with many physical and mental conditions. [9][10][11][12] The severity varies widely, ranging from occurring only occasionally to frequently and severely with disruption of sleep.…”

mentioning

confidence: 99%

Restless legs symptoms with sleepiness in relation to mortality: 20‐year follow‐up study of a middle‐aged Swedish population

Mallon

Broman

Hetta

2008

Psychiatry Clin Neurosci

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Aim:The aim of the present study was to investigate restless legs symptoms with concomitant daytime sleepiness as a risk factor for mortality in a middleaged population.Methods: A cohort of 5102 subjects aged 30-65 years in mid-Sweden who responded to a postal questionnaire in 1983 was followed up. The questionnaire included questions about restless legs symptoms, daytime sleepiness, demographic and lifestyle variables, sleep habits, medical conditions and depression. Mortality data for the period 1983-2003 were collected and death certificates were available for all the 657 responders who died during the follow-up period.Results: Restless legs symptoms with daytime sleepiness was reported by 10.3% and was associated with shorter night sleep time, several health problems and depression. During the follow-up period 379 men (21.6%) and 278 women (15.5%) died. A multivariate model adjusted for age, short night sleep time, lifestyle factors, medical conditions and depression showed that women reporting restless legs symptoms with daytime sleepiness had an excess mortality compared to women without restless legs symptoms and daytime sleepiness (hazard ratios, 1.85; 95% confidence interval, 1.20-2.85; P = 0.005). No influence on mortality risk was found in men reporting restless legs symptoms with daytime sleepiness. Conclusions:The occurrence of restless legs symptoms with daytime sleepiness in middle-aged women is associated with increased mortality risk.

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“…This proportion is slightly higher than the 25% percent prevalence reported by Nichols et al, 35 and is considerably higher than the rates of 7.2% and 9% reported in 2 general population surveys. 36,37 This discrepancy may reflect that, although relatively common, RLS is often not diagnosed by physicians. In one study from 6 countries, 81% of the 416 respondents with RLS symptoms reported discussing their symptoms with a primary care physician, but only 21 (6.2%) were given a diagnosis of RLS.…”

mentioning

confidence: 99%

Sleep Problems in Primary Care: A North Carolina Family Practice Research Network (NC-FP-RN) Study

Alattar¹,

Harrington²,

Mitchell³

et al. 2007

The Journal of the American Board of Family Medicine

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Background:The prevalence and nature of sleep disorders in primary care has not been widely studied. As part of a survey conducted in 5 family practice offices in North Carolina, we screened adult patients for sleep syndromes and sought to ascertain which demographic status and health status were associated with these disorders.Methods: We approached 2963 consecutive adults who presented for office visits to the 5 study practices. The 4-page study questionnaire, which was available in English and Spanish, included items on insomnia, excessive daytime sleepiness, obstructive sleep apnea syndrome, and restless legs syndrome. Analyses evaluated the relationship between sleep syndromes and demographic factors, health status, and disability.Results: We enrolled 1935 patients (65.3% response rate). More than half reported excessive daytime sleepiness, one third had insomnia, more than 25% had symptoms of restless legs syndrome, and 13% to 33% reported obstructive sleep apnea syndrome symptoms. Participants who rated their health as poor reported significantly higher rates of all sleep disturbance items. Patients with hypertension, pain syndromes, and depression had a significantly increased risk for all sleep complaints. Patients who reported limited activity had a significant risk of restless legs syndrome. Conclusion

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Epidemiology of restless legs syndrome in French adults

Abstract: Restless legs syndrome (RLS) occurred in 10% of women and 5% of men. RLS prevalence decreases after the age of 64. RLS is often underdiagnosed and few subjects receive recommended RLS drug treatment.

Cited by 296 publications

References 30 publications

Prevalence of residual excessive sleepiness in CPAP-treated sleep apnoea patients: the French multicentre study

Prevalence of residual excessive sleepiness in CPAP-treated sleep apnoea patients: the French multicentre study

Restless legs symptoms with sleepiness in relation to mortality: 20‐year follow‐up study of a middle‐aged Swedish population

Sleep Problems in Primary Care: A North Carolina Family Practice Research Network (NC-FP-RN) Study

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