Epidemiology of Stomach Cancer

Brenner, Hermann; Rothenbacher, Dietrich; Arndt, Volker

doi:10.1007/978-1-60327-492-0_23

Cited by 497 publications

(373 citation statements)

References 34 publications

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“…As shown in Figure 1, the age-adjusted incidence rates in South Korea, Japan and China are 41.8, 29.9 and 22.7 per 100,000, respectively (compared to 3.9 per 100,000 in the US) (Ferlay et al, 2013). Gastric cancer incidence rates increase progressively with age (Crew and Neugot, 2006;Brenner et al, 2009). Gender is strongly associated with gastric cancer risk and men have markedly higher incidence rates than women (Crew and Neugot, 2006;Brenner et al, 2009;Ferlay et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

Gastric Cancer in Asian American Populations: a Neglected Health Disparity

Taylor

Hwang

et al. 2015

Asian Pacific Journal of Cancer Prevention

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Gastric cancer incidence rates vary dramatically by world region with East Asia having the highest rate. The Asian population of the United States (US) is growing rapidly and over 17 million Americans are of Asian descent. A majority of Chinese, Korean and Vietnamese Americans are immigrants. Americans of East and Southeast Asian descent experience marked gastric cancer disparities and the incidence rate among Korean men in the US is over five times higher than the incidence rate among non-Hispanic white men. Randomized controlled trials have provided evidence for the effectiveness of helicobacter pylori identification and eradication in preventing gastric cancer. Additionally, Japan and South Korea have both experienced improvements in gastric cancer mortality following the implementation of programs to detect early stage gastric cancers. There are currently no clear US guidelines regarding the primary and secondary prevention of gastric cancer in high-risk immigrant populations. However, it is likely that a proportion of US physicians are already recommending gastric cancer screening for Asian patients and some Asian immigrants to the US may be completing screening for gastric cancer in their native countries. Surveys of US primary care physicians and Asian American communities should be conducted to assess current provider practices and patient uptake with respect to gastric cancer prevention and control. In the absence of clinical guidelines, US health care providers who serve high-risk Asian groups could consider a shared decision-making approach to helicobacter pylori identification and eradication, as well as gastric endoscopy.

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Section: Introductionmentioning

confidence: 99%

Gastric Cancer in Asian American Populations: a Neglected Health Disparity

Taylor

Hwang

et al. 2015

Asian Pacific Journal of Cancer Prevention

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“…Gastric cancer, the second most common cause of cancer-related death in the world, is characterized as a multifactorial disease that results from individual genetic predisposition and exposure to environmental factors (Brenner et al, 2009). According to anatomic site, gastric cancer can be classified as cardia and non-cardia subtypes.…”

Section: Introductionmentioning

confidence: 99%

Lack of Association of Common Polymorphisms in MUC1 Gene with H. pylori Infection and Non-cardia Gastric Cancer Risk in a Chinese Population

Zhang

Hao²,

Gao³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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Several lines of evidence support the notion that MUC1 is often aberrantly expressed in gastric cancer, and it is a ligand for Helicobacter pylori. Genetic variation in MUC1 gene may confer susceptibility to H. pylori infection and gastric cancer. We assessed the association of common polymorphisms in MUC1 gene with H. pylori infection and non-cardia gastric cancer using an LD-based tag SNP approach in north-western Chinese Han population. A total of four SNPs were successfully genotyped among 288 patients with non-cardia gastric cancer and 281 age-and sex-matched controls. None of the tested SNPs was associated with H. pylori infection. SNP rs9426886 was associated with a decreased risk of non-cardia gastric cancer, but lost significance after adjustment for multiple testing. Overall, our data indicated that common genetic variations in MUC1 gene might not make a major contribution to the risk of H. pylori infection and non-cardia gastric cancer in our studied population.

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“…31 It is believed that some (not yet fully elucidated) role is played by female sex hormones in the process of gastric carcinogenesis. 32 It has been suggested that, not unlike breast cancer, later age at menarche 33 , older menopause, and nulliparity 34 are associated with increased risk of development of gastric carcinoma in women.…”

Section: Estrogen and Gastric Cancermentioning

confidence: 99%

Estrogen and gastrointestinal malignancy

Hogan¹,

Collins²,

Baird³

et al. 2009

Molecular and Cellular Endocrinology

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Summary:The concept that E2 exerts an effect on the gastrointestinal tract is not new and its actions on intestinal mucosa have been investigated for at least three decades. An attempt to consolidate results of these investigations generates more questions than answers, thus suggesting that many unexplored avenues remain and that the full capabilities of this steroid hormone are far from understood. Evidence of its role in esophageal, gastric and gallbladder cancers is confusing and often equivocal. The most compelling evidence regards the protective role conferred by estrogen (or perhaps ERβ) against the development and proliferation of colon cancer. Not only has the effect been described but many mechanisms of action have been explored. It is likely that, along with surgery, chemotherapy and radiotherapy, hormonal manipulation will play an integral role in colon cancer management in the very near future.Introduction:

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Epidemiology of Stomach Cancer

Cited by 497 publications

References 34 publications

Gastric Cancer in Asian American Populations: a Neglected Health Disparity

Gastric Cancer in Asian American Populations: a Neglected Health Disparity

Lack of Association of Common Polymorphisms in MUC1 Gene with H. pylori Infection and Non-cardia Gastric Cancer Risk in a Chinese Population

Estrogen and gastrointestinal malignancy

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