Epidemiology of Surgically Treated Spinal Tumors: A Multicenter Surveillance Study of 9686 Patients from the German Spine Registry (DWG Register)

Walter, Sebastian; Gaisendrees, Christopher; Kernich, Nikolaus; Weber, Maximilian; Scheyerer, Max Joseph; Eysel, Peer; Siewe, Jan; Zarghooni, Kourosh

doi:10.1055/a-2077-7155

Cited by 3 publications

(2 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Affektionen des Myelons durch lokale Tumorkompressionen oder sekundären spinalen Instabilitäten durch osteolytisch bedingte Frakturen treten bei einem Anteil von ca. 1-12% auf, wobei insbesondere Patienten mit hormon-refraktärem Prostatakarzinom in bis zu 80% der Fälle Wirbelkörpermetastasen entwickeln [3,4,5,6].…”

Section: Allgemeinesunclassified

Akuter Querschnitt unter Systemtherapie – Radiotherapie oder OP?

Ujkic,

Sutanto,

Knöll

et al. 2023

Aktuelle Urol

Self Cite

View full text Add to dashboard Cite

Zusammenfassung Wirbelkörper sind eine der häufigsten Metastasenlokalisationen beim fortgeschrittenen Prostatakarzinom. Einerseits schränken Wirbelsäulenmetastasen durch begleitende Rückenschmerzen die Lebensqualität der Patienten stark ein, andererseits können Sekundärkomplikationen auftreten, die mit schwerwiegenden neurologischen Ausfallerscheinungen und Funktionsverlusten einhergehen. Neben der Schmerzreduktion stellen zum einen die lokale Tumorkontrolle, zum anderen die Wiederherstellung der spinalen Stabilität zentrale Therapieziele dar. Der Stellenwert der Chirurgie, der konventionellen Strahlentherapie und stereotaktischen Strahlentherapie, sowohl alleinstehend als auch kombiniert, wird vor diesem Hintergrund in der Literatur kontrovers diskutiert. Insbesondere der NOMS-Score erweist sich als hilfreiches Tool zur therapeutischen Entscheidungsfindung. Daten zeigen bessere postoperative Patientenoutcomes nach chirurgischer Therapie, sowohl wenn isoliert durchgeführt als auch kombiniert mit der Strahlentherapie, wobei ein Teil der untersuchten Patientenkollektive andere Primaria neben dem Prostatakarzinom miteinschließen. Vergleichsstudien, die speziell im Setting des metastasierten Prostatakarzinoms die Überlegenheit bestimmter Therapien vergleichen, sind rar. Dasselbe gilt in Bezug auf mikrochirurgische Eingriffe an spinalen Metastasen. Die isolierte Strahlentherapie nimmt insbesondere im Setting der Palliation zur Schmerzlinderung ihren Stellenwert ein, wobei ihre Effektivität zahlreich belegt ist. Therapeutisch entscheidungsführend ist die erwartete Lebensprognose der Patienten. Ein multimodaler Therapieansatz ist vor dem Hintergrund des komplexen Patientenkollektivs vonnöten, wobei aktuelle Therapietrends vor dem Hintergrund der Früherkennung spinaler Metastasen großzügiger eine operative Intervention integrieren.

show abstract

Section: Allgemeinesunclassified

Akuter Querschnitt unter Systemtherapie – Radiotherapie oder OP?

Ujkic,

Sutanto,

Knöll

et al. 2023

Aktuelle Urol

Self Cite

View full text Add to dashboard Cite

show abstract

“…Spinal metastases are a frequent diagnosis in about 15% of patients treated for an oncologic disease, and most likely this incidence is systematically underestimated [1][2][3]. In general and most cases, progression of spinal metastases is asymptomatic until the terminal phase.…”

Section: Introductionmentioning

confidence: 99%

Local Recurrence and Development of Spinal Cord Syndrome during Follow-Up after Surgical Treatment of Metastatic Spine Disease

Knoell,

Lenschow,

Lenz

et al. 2023

Preprint

View full text Add to dashboard Cite

Background: Surgical decompression (SD) with and without posterior stabilization followed by radiotherapy is an established treatment for patients with metastatic spinal disease with epidural spinal cord compression (ESCC). This study aims to identify risk factors for occurrence of neurologic comprise resulting from local recurrence. Methods: All patients who received surgical treatment for metastatic spinal disease at our center between 2011 and 2022 were included in this study. Cases were evaluated for tumor entity, surgical technique for decompression (decompression, hemilaminectomy, laminectomy, corpectomy) neurological deficits, grade of ESCC, time interval to radiotherapy and perioperative complications. Results: A total of 747 patients were included in the final analysis, with a follow-up of 296.8 days (95% CI (263.5, 330.1)). During the follow-up period 7.5% of patients developed spinal cord/cauda syndrome (SCS). Multivariate analysis revealed prolonged time (&gt; 35 d) to radiation therapy as solitary risk factor (p &lt; 0.001) for occurrence of SCS during follow-up. Conclusion: Surgical treatment of spinal metastatic disease improves patients’ quality of life and Frankel grade but radiation therapy needs to be scheduled within a time frame of few weeks in order to reduce the risk of tumor-induced neurologic comprise.

show abstract

Local Recurrence and Development of Spinal Cord Syndrome during Follow-Up after Surgical Treatment of Metastatic Spine Disease

Knöll,

Lenschow,

Lenz

et al. 2023

Cancers

Self Cite

View full text Add to dashboard Cite

Background: Surgical decompression (SD), with or without posterior stabilization followed by radiotherapy, is an established treatment for patients with metastatic spinal disease with epidural spinal cord compression (ESCC). This study aims to identify risk factors for occurrence of neurological compromise resulting from local recurrence. Methods: All patients who received surgical treatment for metastatic spinal disease at our center between 2011 and 2022 were included in this study. Cases were evaluated for tumor entity, surgical technique for decompression (decompression, hemilaminectomy, laminectomy, corpectomy) neurological deficits, grade of ESCC, time interval to radiotherapy, and perioperative complications. Results: A total of 747 patients were included in the final analysis, with a follow-up of 296.8 days (95% CI (263.5, 330.1)). During the follow-up period, 7.5% of the patients developed spinal cord/cauda syndrome (SCS). Multivariate analysis revealed prolonged time (>35 d) to radiation therapy as a solitary risk factor (p < 0.001) for occurrence of SCS during follow-up. Conclusion: Surgical treatment of spinal metastatic disease improves patients’ quality of life and Frankel grade, but radiation therapy needs to be scheduled within a time frame of a few weeks in order to reduce the risk of tumor-induced neurological compromise.

show abstract

Epidemiology of Surgically Treated Spinal Tumors: A Multicenter Surveillance Study of 9686 Patients from the German Spine Registry (DWG Register)

Cited by 3 publications

References 29 publications

Akuter Querschnitt unter Systemtherapie – Radiotherapie oder OP?

Akuter Querschnitt unter Systemtherapie – Radiotherapie oder OP?

Local Recurrence and Development of Spinal Cord Syndrome during Follow-Up after Surgical Treatment of Metastatic Spine Disease

Local Recurrence and Development of Spinal Cord Syndrome during Follow-Up after Surgical Treatment of Metastatic Spine Disease

Contact Info

Product

Resources

About