Epidemiology of tongue squamous cell carcinoma: A retrospective cohort study

Souto, Ana Carolina da Silva; Heimlich, Fernanda Vieira; Oliveira, Letícia Lima de; Bergmann, Anke; Dias, Fernando Luiz; Antunes, Héliton Spíndola; Melo, Andréia Cristina de; Thuler, Luiz Cláudio Santos; Goldemberg, Daniel Cohen

doi:10.1111/odi.13897

Cited by 15 publications

(10 citation statements)

References 42 publications

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“…Smokers and drinkers would impair the detoxifying system of GSTs, potentially increasing their susceptibility to carcinogenesis Frontiers in Genetics frontiersin.org (Soares et al, 2017). Many previous studies have shown that tobacco and alcohol are related to HNSC carcinogenesis and reduce the efficacy of tumor-targeted therapy (Jethwa and Khariwala, 2017;da Silva Souto et al, 2021). Multivariate logistic regression further confirmed that T stage and smoker history were independent significant factors of GSTK1 expression.…”

Section: Discussionmentioning

confidence: 65%

Prognostic biomarker GSTK1 in head and neck squamous cell carcinoma and its correlation with immune infiltration and DNA methylation

Feng

Zhou²,

Zhao³

et al. 2023

Front. Genet.

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Background: Glutathione S-transferase kappa 1 (GSTK1) is critical in sarcoma and breast cancer (BRCA) development. However, the clinical significance of GSTK1 in head and neck squamous cell carcinoma (HNSC) remains unclear. This study is the first investigation into the role of GSTK1 in HNSC.Methods: All original data were downloaded from the Cancer Genome Atlas (TCGA) dataset and verified by R Base Package 4.2.0. The expression of GSTK1 in various cancers was explored with TIMER and TCGA databases. Prognostic value of GSTK1 was analyzed via survival module of Kaplan-Meier plotter and Human Protein Atlas database and Cox regression analysis. The association between GSTK1 and clinical features was evaluated by Wilcoxon signed-rank test and logistic regression analysis. The relationship between GSTK1 and immune infiltration and methylation level was further explored. The expression of GSTK1 and its correlation with immune cell infiltration was verified by Immunohistochemical staining (IHC).Results: GSTK1 was lower in HNSC, BRCA, Lung squamous cell carcinoma, and Thyroid carcinoma than in para-carcinoma. Low GSTK1 expression was associated with worse overall survival in Bladder urothelial carcinoma, Kidney renal papillary cell carcinoma, BRCA, and HNSC. However, only in BRCA and HNSC, GSTK1 expression in tumors was lower than that in normal tissues. Cox regression analyses confirmed that GSKT1 was an independent prognostic factor of overall survival in HNSC patients. The decrease in GSTK1 expression in HNSC was significantly correlated with high T stage and smoker history. IHC showed that the expression level of GSTK1 in HNSC was lower than that in para-carcinoma. In addition, GSEA showed that three pathways related to immune infiltration were positively correlated, while two pathways related to DNA methylation were negatively correlated with expression of GSTK1. Further analysis showed that GSTK1 was moderately positively correlated with the infiltration level of T cells and Cytotoxic cells, which was further confirmed by IHC. The methylation level of GSTK1 was associated with prognosis in patients with HNSC.Conclusion: Low GSTK1 expression may be a potential molecular marker for poor prognosis in HNSC and provide new insight for the development of diagnostic marker or therapeutic target.

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Section: Discussionmentioning

confidence: 65%

Prognostic biomarker GSTK1 in head and neck squamous cell carcinoma and its correlation with immune infiltration and DNA methylation

Feng

Zhou²,

Zhao³

et al. 2023

Front. Genet.

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“…Two tumor cell clusters were distinguished based on the expression of the KRT1, KRT4, KRT5, KRT10, KRT13 , and KRT14 genes (Figure 1C). Tumor microenvironment cells were detected as clusters of TAFs and lymphoid and myeloid immune cells (Figure 1B, 1C). Two clusters were mixed with fibroblasts (“tumor + TAFs”) and lymphoid cells (“tumor 3 + lymphoid cells”; Figure 1B, 1C).…”

Section: Resultsmentioning

confidence: 99%

“…Tumor microenvironment cells were detected as clusters of TAFs and lymphoid and myeloid immune cells (Figure 1B, 1C). Two clusters were mixed with fibroblasts (“tumor + TAFs”) and lymphoid cells (“tumor 3 + lymphoid cells”; Figure 1B, 1C). Next, we focused on tumor and immune cell types as key players in tumorigenesis.…”

Section: Resultsmentioning

confidence: 99%

Revealing Molecular Mechanisms of Early-Onset Tongue Cancer by Spatial Transcriptomics

Patysheva,

Kolegova,

Khozyainova

et al. 2023

Preprint

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Tongue cancer at a young age demonstrates an increase in incidence, aggressiveness, and poor response to therapy. Classic etiological factors for head and neck tumors such as tobacco, alcohol, and human papillomavirus are not related to early-onset tongue cancer. Mechanisms of development and progression of this cancer remain unclear. In this study, we performed spatial whole-transcriptome profiling of tongue cancer in young adults compared with elderly patients. Oxidative stress, vascular mimicry, and MAPK and JAK-STAT pathways were enriched in early-onset tongue cancer. Tumor microenvironment demonstrated increased gene signatures corresponding to myeloid-derived suppressor cells, tumor-associated macrophages, and plasma cells. The invasive front was accompanied by vascular mimicry with arrangement of tumor-associated macrophages and aggregations of plasma cells and lymphocytes organized into tertiary lymphoid structures. Taken together, these results indicate that early-onset tongue cancer has distinct spatial transcriptomic features and molecular mechanisms compared to older patients.

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“…Tongue squamous cell carcinoma (TSCC) is the most common malignancy in oral cavity (1). Despite improvements in diagnostic tools and treatment modalities, the mortality rate of TSCC has not diminished in recent years and 5-year survival rate for TSCC is still below 50% (2,3). Tumor-node-metastasis (TNM) staging system of the American Joint Committee on Cancer (AJCC) is the most commonly used method to determine treatment modalities and to predict patient prognosis.…”

Section: Introductionmentioning

confidence: 99%

Prognostic role of primary tumor metabolic-volumetric parameters of 18F-fluorodeoxyglucose positron emission tomography in tongue squamous cell carcinoma

Aydos

Cebeci

2023

Journal of Health Sciences and Medicine

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Aim: It was aimed to evaluate the prognostic role of primary tumor metabolic-volumetric parameters of 18F-Fluorodeoxyglucose (18F-FDG) positron emission tomography/computed tomography (PET/CT) in resectable tongue squamous cell carcinoma (TSCC). Materials and Methods: The imaging findings of 44 TSCC patients (23 females, 21 males, mean age: 58 ± 12) with resectable tumors who underwent 18F-FDG PET/CT imaging for primary staging before surgery between 2010-2021 were evaluated retrospectively. Maximum standardized uptake value (SUVmax), total lesion glycolysis (TLG), metabolic tumor volume (MTV) of primary tumors were acquired from PET/CT. Histopathological risk factors (pathological tumor and nodal stage, perineural and lymphovascular invasion, depth of invasion, surgical margin positivity) obtained from surgical resection material of primary tumors were also recorded. The prognostic values of imaging and histopathological parameters were assessed by Cox proportional hazards regression models. Survival curves were estimated by using the Kaplan-Meier analysis. Results: The median follow-up period after diagnosis was 24 months (range: 2-152 months). The univariate and multivariate regression analyses demonstrated that MTV was the only parameter which was significantly related to prognosis for PFS and OS. The patients with higher MTV (> 3.13 cm3) had lower OS and PFS rates compared to those with lower MTV (≤ 3.13 cm3) (p = 0.002, p < 0.001, respectively). Conclusion: Primary tumor MTV is an independent prognostic factor in resectable TSCC. PET volumetric features can be used as prognostic biomarker to predict patients with poor prognosis.

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Epidemiology of tongue squamous cell carcinoma: A retrospective cohort study

Cited by 15 publications

References 42 publications

Prognostic biomarker GSTK1 in head and neck squamous cell carcinoma and its correlation with immune infiltration and DNA methylation

Prognostic biomarker GSTK1 in head and neck squamous cell carcinoma and its correlation with immune infiltration and DNA methylation

Revealing Molecular Mechanisms of Early-Onset Tongue Cancer by Spatial Transcriptomics

Prognostic role of primary tumor metabolic-volumetric parameters of 18F-fluorodeoxyglucose positron emission tomography in tongue squamous cell carcinoma

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