Epidemiology of tuberculosis and leprosy, Sabah, Malaysia

Dony, Jiloris F.; Ahmad, Jamaliah; Tiong, Yap Khen

doi:10.1016/j.tube.2003.08.002

Cited by 41 publications

(32 citation statements)

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“…The majority of the foreigners who enrolled in this study were from South East Asian countries, specifically from Malaysia's neighboring countries. In Eastern Malaysia, it has been reported that more than 24% of the newly detected TB cases emerged from immigrants [24].…”

Section: Discussionmentioning

confidence: 99%

Multidrug-resistant tuberculosis and risk factors associated with its development: a retrospective study

Elmi

Hasan

Abdullah

et al. 2015

J Infect Dev Ctries

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Introduction: Multidrug-resistant tuberculosis (MDR-TB) has emerged as a major clinical public health threat and challenges the national TB control program in Malaysia. Data that elaborates on the risk factors associated with the development of MDR-TB is highly limited in this country. This study was aimed to determine the risk factors associated with the development of MDR-TB patients in peninsular Malaysia. Methodology: This was a case control study; the data were collected from medical records of all the registered MDR-TB patients at five referral TB hospitals in peninsular Malaysia from January 2010 to April 2014. The 105 cases were all confirmed by a positive sputum culture of Mycobacterium tuberculosis for MDR-TB and extensively drug-resistant (XDR)-TB. As a comparison, a total of 209 non-MDR-TB cases were randomly selected as controls. Results: A total of 105 MDR-TB and 209 non MDR-TB patients were studied. The risk factors associated with MDR-TB within the multivariate analysis were previous tuberculosis treatment, HIV infection, being an immigrant, and high load of positive for acid-fast bacillus (AFB) smear. Conclusions: The findings of this study revealed that patients who had received previous treatment for tuberculosis, were infected with HIV, were immigrants, and had a high burden of positive testing for AFB smear were more likely to have MDR-TB. An enhanced understanding of the risk factors associated with MDR-TB strains is imperative in the development of a national policy for public health interventions.

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Section: Discussionmentioning

confidence: 99%

Multidrug-resistant tuberculosis and risk factors associated with its development: a retrospective study

Elmi

Hasan

Abdullah

et al. 2015

J Infect Dev Ctries

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“…This is mainly due to the lack of new drugs, particularly for effective treatment against MDR-TB, XDR-TB, and patients co-infected with HIV/AIDS. Therefore, there is an urgent need for the development of new and effective anti-TB drugs particularly against resistant strains with lesser side-effects [117][118][119]. More importantly, the newly developed drugs are required to reduce the duration of treatment.…”

Section: Resultsmentioning

confidence: 99%

Recent Efforts for the Development of Antitubercular Drug Containing Diazine Ring

Asif¹

2012

Med chem

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There has been considerable interest in the development of new molecule with antibacterial activities particularly against tuberclosis because mycobacterium species have developed resistant against currently used drugs, their toxic effect and long duration of therapy. The diazine (pyridazine, pyrimidine and piperazine) derivatives possess an important class of compound for new drugs research and development. Therefore, many researchers have synthesized these compounds as target structures and evaluated their antitubercular activity. These observations have been guiding for the development of new molecules that possess potent antitubercular activity with minimum side effects or effective against MDR, XDR mycobacterium strains, and also in patient co-infected with HIV/AIDS.

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“…In Malaysia, TB was the second most common communicable disease in the year 2001 1 . About 24% of TB cases are contributed by the immigrant population, particularly due to the massive influx of immigrants from neighboring countries as well as the increasing number of immunocompromised patients 2 . The incidence is increasing year by year.…”

Section: Introductionmentioning

confidence: 99%

Various presentations of breast tuberculosis and tuberculous lymphadenopathy: A case series of surgical rarity

Sultan¹,

Hayati²,

Azizan³

et al. 2017

MMJ

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Epidemiology of tuberculosis and leprosy, Sabah, Malaysia

Cited by 41 publications

References 1 publication

Multidrug-resistant tuberculosis and risk factors associated with its development: a retrospective study

Multidrug-resistant tuberculosis and risk factors associated with its development: a retrospective study

Recent Efforts for the Development of Antitubercular Drug Containing Diazine Ring

Various presentations of breast tuberculosis and tuberculous lymphadenopathy: A case series of surgical rarity

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