Emerging and re-emerging infectious diseases are a significant public and animal health threat. In some zoonosis, the early detection of virus spread in animals is a crucial early warning for humans. The analyses of animal surveillance data are therefore of paramount importance for public health authorities to identify the appropriate control measure and intervention strategies in case of epidemics. The interaction among host, vectors, pathogen and environment require the analysis of more complex and diverse data coming from different sources. There is a wide range of spatiotemporal methods that can be applied as a surveillance tool for cluster detection, identification of risk areas and risk factors and disease transmission pattern evaluation. However, despite the growing effort, most of the recent integrated applications still lack of managing simultaneously different datasets and at the same time making available an analytical tool for a complete epidemiological assessment. In this paper, we present EpiExploreR, a user-friendly, flexible, R-Shiny web application. EpiExploreR provides tools integrating common approaches to analyze spatiotemporal data on animal diseases in Italy, including notified outbreaks, surveillance of vectors, animal movements data and remotely sensed data. Data exploration and analysis results are displayed through an interactive map, tables and graphs. EpiExploreR is addressed to scientists and researchers, including public and animal health professionals wishing to test hypotheses and explore data on surveillance activities.Microorganisms 2019, 7, 680 2 of 23 environmental component involves the use of data, which although widely available nowadays, are unstructured and extremely large.All this makes such data of limited use if not converted through proper data management and analytical methods that can handle the heterogeneous datasets, transforming these into information useful to decision and policy makers [12,13].However, as new data and computational resources have become available, a wide range of spatial and spatiotemporal methods have been developed for early outbreak detection, cluster detection, identification of risk areas and risk factors and disease transmission pattern evaluation [14][15][16][17]. The application of these increasingly complex statistical methods is fortunately facilitated by the growing development of the open-source community, among which the most widespread and popular is certainly R [18], a programming language and free software environment for statistical computing and graphics. Several R-packages (e.g., surveillance, sp, rSaTScan, network, tsna, igraph) [19][20][21][22][23][24] have been made available to researchers, but their use still requires adequate programming and statistical skills to write down codes and to perform the analysis effectively.To overcome this lack in technical skills, desktop and web applications have been developed, providing analysis tools ready to use for researchers and public and animal health professionals [25-30]. Among ...