Epidermal barrier function changes after ablative and non-ablative fractional laser administration

Kim, J.M.; Kim, W.I.; Ko, Hyun Chang; Kim, M.B.; Kim, B.S.

doi:10.1111/jdv.13750

Cited by 10 publications

(11 citation statements)

References 5 publications

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“…After using light-based therapies, the epidermal disruption is usually inevitable because of skin damage, dermatologists often attempt to minimize side reactions. 5 The development of skin care regimens which can accelerate the recovery of inflammation and reduce post-treatment side reactions will contribute to the promotion of the application of light-based therapies and facilitate patients to accept such treatments.…”

Section: Discussionmentioning

confidence: 99%

“…Fractional laser resurfacing treatments that use multiple laser passes or inadvertent stacking will increase the risk of prolonged erythema 4 . Compared to nonablative fractional laser therapy, ablative laser therapy causes heavier skin barrier dysfunction 5 . It takes a certain recovery time after treatment, which partly extends the duration of labor incapacity.…”

Section: Introductionmentioning

confidence: 99%

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Administration of skin care regimens containing β‐glucan for skin recovery after fractional laser therapy: A split‐face, double‐blinded, vehicle‐controlled study

Cao

Wang

Zhang

et al. 2020

J of Cosmetic Dermatology

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Background: Laser therapies have brought dawn to refractory skin diseases, but also were accompanied by postlaser inflammation and skin barrier dysfunction. To recover skin function quickly, the research and development of active ingredients including β-glucan for postlaser repair have attracted much attention. Aims: To evaluate the efficacy and tolerance of skin care regimens containing β-glucan (Dermdoc®;Songyang Biotech) in repairing postlaser inflammation and skin barrier dysfunction after fractional laser therapy. Methods: A total of 20 patients with facial atrophic acne scars who accepted fractional laser therapy were recruited: 10 patients treated with ablative fractional CO2 laser and 10 patients treated with 1565nm nonablative fractional laser. Using the method of split-face vehicle-control study, the left half of the face was served as the treatment side and accepted skin care regimens, and the right half was control side accepted vehicle. Noninvasive bioinstrumentation of skin hydration index, transepidermal water loss (TEWL), and hemoglobin index (E value) was detected in the study.Standard digital photographs were taken at each visit. The skin tolerance and adverse effect were also evaluated by subject questionnaire.Results: Compared with the control side, the Hemoglobin index (E value) of the treatment side was improved more significantly on the 7th day (P < .05). The skin hydration index of the treatment side was better than that of the control side on the 7th and 14th day (P < .05). After treatment, the TEWL of the treatment side on the 7th day was statistically significantly lower than that of the control side (P < .05). In the subject self-assessment questionnaires, 63.2% thought the repair effect of β-glucan regimens was better than that of vehicle. The skin care regimens were well tolerated without obvious side reactions. Conclusion:The skin care regimens containing β-glucan may play a positive role in accelerating the recovery of skin inflammation and barrier function after fractional laser therapy.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Administration of skin care regimens containing β‐glucan for skin recovery after fractional laser therapy: A split‐face, double‐blinded, vehicle‐controlled study

Cao

Wang

Zhang

et al. 2020

J of Cosmetic Dermatology

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“…The development of cosmetic biomimetic lamellar lipid topical formulations to improve skin health has been a focus of research at our skin health laboratories. The clinical efficacy of our earlier formulations has been reported and other studies have looked at the use of a lamellar moisturizer in skin conditions or after fractional laser administration . In previous publications, we have discussed the development and use of biophysical methods to measure, characterize and demonstrate the molecular organization and in vitro barrier efficacy of our topical formulations containing biomimetic technology .…”

Section: Introductionmentioning

confidence: 95%

Cosmetic benefit of a biomimetic lamellar cream formulation on barrier function or the appearance of fine lines and wrinkles in randomized proof‐of‐concept clinical studies

Nisbet

Mahalingam

Gfeller

et al. 2019

Intern J of Cosmetic Sci

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ObjectiveTwo studies were designed to evaluate the potential cosmetic benefit of a biomimetic, niacinamide‐containing moisturizing cream for the first time in humans.MethodsIn both studies, healthy women were randomized to use two treatments, one for the left side of the body and one for the right, from three options: the test cream, a positive control or no treatment (use of standard cleanser only). Treatments were applied twice daily for 4 weeks to the face and forearms (Study 1) or the face only (Study 2). Instrumental and clinical skin assessments were performed by trained technicians. Study 1 involved tape stripping and a 5‐day no‐treatment (‘regression’) period at the end of the 4 weeks. Independent lay graders were asked to grade the skin texture of subjects in Study 2 from high‐resolution photographs.ResultsIn Study 1 (n = 66), the test cream significantly decreased the transepidermal water loss (TEWL) values on the forearm, and in the cheek area of the face, relative to baseline and compared to no treatment, and increased skin Corneometer values. The improvements were partially retained during a subsequent 5‐day period of no treatment. Increases in TEWL values on skin subjected to tape stripping were significantly lower after 4 weeks of using the test cream compared to no treatment. In Study 2 (n = 72 subjects with visible signs of ageing), there was a favourable trend in the change from baseline of a skin roughness parameter, Ra, for the test cream compared to no treatment. There were statistically significant improvements in the Fitzpatrick wrinkle score compared to no treatment, decreases in TEWL and increased Corneometer values and Cutometer values (R5 elasticity parameter). Grading of high‐resolution images failed to detect the improvements in skin texture (defined as pores, smoothness and unevenness) for the test cream vs. no treatment. No treatment‐related serious or severe adverse events were reported.ConclusionTwice daily application of the test cream over 4 weeks had beneficial effects on skin barrier function, moisturization, wrinkle dimensions and elasticity compared to no treatment. These studies provide proof‐of‐concept evidence and highlight the cosmetic benefit of the biomimetic lamellar cream formulation. Study registration: NCT03216265, NCT03180645.

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“…Q‐switched 1064‐nm Nd: YAG laser (1064‐QSNYL) was the first laser used for nonexfoliative skin rejuvenation 4 . The effect of nonexfoliative laser on skin rejuvenation is mainly to damage skin dermis through the photothermal and mechanical effects, so that part of the collagen is denatured, thereby activating the benign self‐repair process of the tissue and stimulating fibrogenesis cell proliferation, while promoting the reorganization and proliferation of collagen 5,6 . As early as 1997, studies have shown that 1064‐QSNYL can improve skin texture, elasticity, and facial wrinkles 7 .…”

Section: Introductionmentioning

confidence: 99%

The effect of Q‐switched 1064‐nm Nd: YAG laser on skin barrier and collagen synthesis via miR‐663a to regulate TGFβ1/smad3/p38MAPK pathway

Yang

Duan

Wang

et al. 2021

Photoderm Photoimm Photomed

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Background: Our previous research found that Q-switched 1064-nm Nd: YAG laser (1064-QSNYL) induces skin collagen synthesis by activating TGFβ1/Smad3/ p38MAPKs pathway. Moreover, a lot of studies shown that MicroRNAs (miRNAs) contribute to regulate collagen synthesis and skin barrier. Therefore, we intend to explore the mechanism of 1064-QSNYL on collagen synthesis and skin barrier through miRNAs. Methods:We predicted the upstream miRNAs of TGFβ1 by bioinformatics databases, and verified them through dual-luciferase reporter genes and Western blotting. The expression of collagen, skin barrier-related protein K10 and filaggrin, TIMP-1, and MMP-2 were detected by RT-qPCR and Western blotting, respectively. Moreover, we detected moisture content, elasticity value, TEWL value, SOD vitality, and hydroxyproline content to evaluate skin barrier of mice. H&E staining to observe the change of dermis thickness and inflammation and infiltration of mice skin. Results:The results shown that TGFβ1 was target gene of miR-663a. Moreover, we found that 1064-QSNYL activated TGFβ1/smad3/p38MAPK pathway by downregulating the expression of miR-663a in HaCaT, HDF cells, and mice, thereby promoting expression of Collagen I, Collagen IV, TIMP-1, K10, and filaggrin and inhibiting MMP-2. Furthermore, 1064-QSNYL contributed to moisture content, elasticity, SOD vitality, and hydroxyproline content via miR-663a to activate TGFβ1/smad3/ p38MAPK pathway. Conclusions:In summary, this study found for the first time that 1064-QSNYL contributed to collagen synthesis and skin repair via miR-663a to regulate TGFβ1/smad3/ p38MAPK pathway, thereby achieving skin rejuvenation.

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Epidermal barrier function changes after ablative and non-ablative fractional laser administration

Cited by 10 publications

References 5 publications

Administration of skin care regimens containing β‐glucan for skin recovery after fractional laser therapy: A split‐face, double‐blinded, vehicle‐controlled study

Administration of skin care regimens containing β‐glucan for skin recovery after fractional laser therapy: A split‐face, double‐blinded, vehicle‐controlled study

Cosmetic benefit of a biomimetic lamellar cream formulation on barrier function or the appearance of fine lines and wrinkles in randomized proof‐of‐concept clinical studies

The effect of Q‐switched 1064‐nm Nd: YAG laser on skin barrier and collagen synthesis via miR‐663a to regulate TGFβ1/smad3/p38MAPK pathway

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