Epidermal growth factor receptor antibody plus recombinant human endostatin in treatment of hepatic metastases after remnant gastric cancer resection

Long, Mark D.; Sun, Dong; Huang-Yang,; Ye, Jianhuai; Yinghong,; Zhang, Bo; Yong-Song,; Guan,; Hua, Hua; Wu, Kan

doi:10.3748/wjg.13.6115

Cited by 14 publications

(9 citation statements)

References 6 publications

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“…Many studies reported that the expressions of EGF and VEGF were related to the invasion and metastasis of gastric cancer cells [5][6][7] . EGF belongs to polypeptide growth factors and widely exists in the tissues and body fluids in both human beings and animals.…”

Section: Discussionmentioning

confidence: 99%

Relationship between VEGF, EGF and invasion, metastasis of gastric cancer cells

Yin

et al. 2009

Chin. J. Cancer Res.

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Objective: To investigate the relationship between expression of vascular endothelial growth factor (VEGF), epidermal growth factor (EGF) and the biological properties of gastric cancer cells such as invasion and metastasis.Methods: RT-PCR was performed to semi-quantitatively detect the mRNA expressions of EGF, EGFR, VEGF and VEGFR in four kinds of gastric cancer cell lines BGC823, MGC803, HGC27 and SGC7901, which were classified by their differentiation degree in our experiment. We obtained cell line growth curves from MTT assays. The migration of gastric cancer cells was observed under inverted phase contrast microscope. The changes of invasion and adhesion were detected by a Transwell assay.Results: The growth rates slowed down sequentially in MGC803, HGC27, BGC823 and SGC7901(P＜0.05). The ability of migration, invasion and adhesion were reduced sequentially, and the difference was significant. The expressions of EGF, EGFR, VEGF and VEGFR were significantly stronger in MGC803 and HGC27 than in BGC823 and SGC7901 cells, and the difference was statistically significant(P<0.05).Conclusion: The expressions of VEGF and EGF had close relationship with the properties of migration, adhesion and invasion of gastric cancer cells in vitro. Thus, targeting VEGF and EGF may be a potential therapeutic strategy for inhibiting peritoneal metastasis of gastric cancer.

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Section: Discussionmentioning

confidence: 99%

Relationship between VEGF, EGF and invasion, metastasis of gastric cancer cells

Yin

et al. 2009

Chin. J. Cancer Res.

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“…Recently, endostatin has re-entered the clinic in a modified form that renders it more stable [38]. This modified version is now used in certain countries for the treatment of lung and gastric cancer [39, 40]. …”

Section: Endostatin—a Stroma Derived Tumor Biomarker?mentioning

confidence: 99%

Tumor stroma derived biomarkers in cancer

Sund

Kalluri

2009

Cancer Metastasis Rev

130

108

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In recent years the importance of the tumor stroma for the development, promotion and invasion of cancer is becoming increasingly clear. Besides a malignantly transformed cancer cell, tumors also contains many other cell types, including endothelial cells, fibroblasts and cells of the immune system. These cells together with the cancer cells produce the sum extracellular matrix (ECM) of the tumor. The ECM and the non-malignant cells of the tumor are defined as the “tumor stroma”. Just as the malignant cell itself can be the source of substances that can be used as biomarkers of cancer, the tumor stroma contains factors that potentially can be used as biomarkers when treating patients with cancer. In this review we will discuss the role of the tumor stroma as a source of new cancer biomarkers. This concept highlights a novel view of cancer and treats them as organized organs. Additionally, this further stresses the importance of including factors related to the tumor stroma into the diagnostic and therapeutic equation of cancer.

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“…This modification results in a more stable molecule with similar anti-angiogenic activity [70]. This modified endostatin is now used in certain countries for the treatment of lung and gastric cancer [72,73]. Interestingly, it has recently been shown that the levels of circulating endothelial cells and survivinin may be ideal markers predicting efficacy of endostatin treatment in patients with lung cancer [74].…”

Section: Type XVIII Collagen Derived Endostatinmentioning

confidence: 99%

Endogenous Matrix-Derived Inhibitors of Angiogenesis

2010

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Endogenous inhibitors of angiogenesis are proteins or fragments of proteins that are formed in the body, which can inhibit the angiogenic process. These molecules can be found both in the circulation and sequestered in the extracellular matrix (ECM) surrounding cells. Many matrix-derived inhibitors of angiogenesis, such as endostatin, tumstatin, canstatin and arresten, are bioactive fragments of larger ECM molecules. These substances become released upon proteolysis of the ECM and the vascular basement membrane (VBM) by enzymes of the tumor microenvironment. Although the role of matrix-derived angiogenesis inhibitors is well studied in animal models of cancer, their role in human cancers is less established. In this review we discuss the current knowledge about these molecules and their potential use as cancer therapeutics and biomarkers.

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Epidermal growth factor receptor antibody plus recombinant human endostatin in treatment of hepatic metastases after remnant gastric cancer resection

Cited by 14 publications

References 6 publications

Relationship between VEGF, EGF and invasion, metastasis of gastric cancer cells

Relationship between VEGF, EGF and invasion, metastasis of gastric cancer cells

Tumor stroma derived biomarkers in cancer

Endogenous Matrix-Derived Inhibitors of Angiogenesis

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