Epidermal Growth Factor Receptor, Excision-Repair Cross-Complementation Group 1 Protein, and Thymidylate Synthase Expression in Penile Cancer

Dorff, Tanya B.; Schuckman, Anne; Schwartz, Richard S.; Rashad, Sadaf; Bulbul, Ajaz; Cai, Jie; Pinski, Jacek; Ma, Yanling; Danenberg, Kathleen D.; Skinner, Eila C.; Quinn, David I.

doi:10.1016/j.clgc.2016.01.013

Cited by 6 publications

(1 citation statement)

References 29 publications

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“…The EGFR gene has been extensively studied for PC, and its protein and gene dysregulation has been associated with advanced stage, lower overall survival, and lymph node status. It is, therefore, a vital target marker for therapy ( 35 , 36 ).…”

Section: Introductionmentioning

confidence: 99%

Non-Coding RNA in Penile Cancer

et al. 2022

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Penile cancer (PC) still presents a health threat for developing countries, in particular Brazil. Despite this, little progress has been made on the study of markers, including molecular ones, that can aid in the correct management of the patient, especially concerning lymphadenectomy. As in other neoplasms, non-coding RNAs (ncRNAs) have been investigated for penile cancer, with emphasis on microRNAs, piRNAs (PIWI-interacting small RNAs), and long non-coding RNAs (LncRNAs). In this context, this review aims to assemble the available knowledge on non-coding RNA linked in PC, contributing to our understanding of the penile carcinogenesis process and addressing their clinical relevance. ncRNAs are part of the novel generation of biomarkers, with high potential for diagnosis and prognosis, orientating the type of treatment. Furthermore, its versatility regarding the use of paraffin samples makes it possible to carry out retrospective studies.

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Section: Introductionmentioning

confidence: 99%

Non-Coding RNA in Penile Cancer

et al. 2022

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Molekulares Tumorboard Peniskarzinom – eine Herausforderung

Protzel

Hakenberg

2019

Urologe

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Current Management Strategy for Penile Cancer and Future Directions

2017

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Organ preservation (surgical or incorporating radiation) and reconstructive techniques are important considerations for quality of life in penile cancer survivors. Although local recurrence may be higher with organ preservation, salvage therapy appears successful. Inguinal and pelvic node management requires multidisciplinary care, including chemotherapy; optimal use of radiation has not been fully defined. Advanced in understanding the biology of penile cancer, particularly with regard to epidermal growth factor receptor (EGFR) and HPV status, have led to clinical trials of targeted and immune therapy for patients with refractory disease. Refinements in the management of penile cancer are occurring, though level 1 evidence remains scarce. Referral to specialized centers will facilitate successful completion of clinical trials to advance standard care in this disease.

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Epidermal Growth Factor Receptor, Excision-Repair Cross-Complementation Group 1 Protein, and Thymidylate Synthase Expression in Penile Cancer

Cited by 6 publications

References 29 publications

Non-Coding RNA in Penile Cancer

Non-Coding RNA in Penile Cancer

Molekulares Tumorboard Peniskarzinom – eine Herausforderung

Current Management Strategy for Penile Cancer and Future Directions

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