Epidermal growth factor receptor targeted therapy of squamous cell carcinoma of the head and neck

Sharafinski, Mark; Ferris, Robert L.; Ferrone, Soldano; Grandis, Jennifer R.

doi:10.1002/hed.21365

Cited by 114 publications

(121 citation statements)

References 56 publications

(59 reference statements)

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“…Evaluation of cell surface markers is not new in the context of HNSCC. While earlier testing for EGFR density on tumor cell surface was not useful to predict the effectiveness of cetuximab, there seems to be a certain correlation between the extent of presentation of PD1 ligand on tumor cells and the effectiveness of now emerging checkpoint inhibitors in head and neck cancer (42)(43)(44). DNA sequencing approaches are aiming towards identification of future therapy targets, i.e.…”

Section: Anticancer Researchmentioning

confidence: 99%

Spheroid-based 3D Cell Cultures Enable Personalized Therapy Testing and Drug Discovery in Head and Neck Cancer

Hagemann

Jacobi

Hahn

et al. 2017

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Section: Anticancer Researchmentioning

confidence: 99%

Spheroid-based 3D Cell Cultures Enable Personalized Therapy Testing and Drug Discovery in Head and Neck Cancer

Hagemann

Jacobi

Hahn

et al. 2017

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“…Phosphorylation at ser9 can cause various pathological conditions, including epithelial cancers, and GSK-3βser-9 is increasingly becoming a target for oral cancer treatment development [57]. Activation of the PI3K/Akt signaling cascade leads to inhibition of GSK-3β [58] and loss of cell-to-cell contact through negative regulation of the cell adhesion protein, E-cadherin [38,40,41]. This results in enhanced migratory and invasive capacity in HNSCC [5].…”

Section: Discussionmentioning

confidence: 99%

“…The importance of EGFR expression, phosphorylation, and activation of downstream effectors has been well characterized in a variety of tumor types [38][39][40][41]. Upon activation by its growth factor ligands, EGFR undergoes a transition from an inactive monomeric form to active homodimer and heterodimers.…”

Section: Ra Inhibits Egfr Phosphorylation and Abrogates Pi3k And Mapkmentioning

confidence: 99%

Rosmarinic Acid Inhibits Cell Growth and Migration in Head and Neck Squamous Cell Carcinoma Cell Lines by Attenuating Epidermal Growth Factor Receptor Signaling

Tumur¹,

Guerra²,

Yanni³

et al. 2015

J Cancer Sci Ther

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Objective: Active components of natural foods are increasingly receiving attention for their chemopreventive and chemotherapeutic potential in a wide variety of cancers. Rosmarinic acid (RA), a phenolic compound in various herbal plants, is well-recognized for its anti-oxidant, anti-inflammatory, anti-proliferative properties in a variety of cell types. In this report, we describe a novel role for RA as an inhibitor of epidermal growth factor (EGF) stimulated signaling in HNSCC and propose a cellular reactive oxygen species (ROS)-mediated mechanism for the observed effects.Methods: Cellular growth, migration and reactive oxygen species (ROS) profiles were examined in RA-treated and untreated HNSCC cell lines (UM-SCC-6 and UM-SCC-10B) using the WST-1 viability assay, established in vitro migration assays, and the CM-H2DCFDA ROS assay, respectively. The influence of RA on EGF-stimulated phosphorylation and its downstream pathways was evaluated using Western-blotting techniques.Results: RA inhibited cell viability, migration and cellular production of ROS in HNSCC cell lines. Furthermore, RA inhibited EGF-induced phosphorylation of the EGFR at tyrosine residues 992 and 845, which led to downregulation of the phosphatidylinositol 3-kinase Akt (PI3K/Akt) and mitogen-activated protein kinase ERK (MAPK/ ERK) pathways.Conclusions: This is the first report describing both growth-and motility-inhibitory roles for RA in HNSCC cells. Additionally, our study is the first to demonstrate that treatment with RA can reduce EGF-induced activation of PI3K/ Akt in tumor cells. The present data suggests that RA holds promise as a chemotherapeutic agent against HNSCC. a novel strategy to down-regulate EGFR signaling using the phenolic compound, rosmarinic acid. RosmarinicActive components of natural foods are increasingly receiving attention for their chemopreventive and chemotherapeutic potential in a wide variety of cancers. One such food component, rosmarinic acid (RA), is a widely distributed phenolic compound in various herbal plants such as rosemary, sweet basil, sage, mint, and perilla (Figure 1) [10,11]. RA is regarded as a daily-consumed safe ingredient, due to its extensive use in the food industry for flavoring, but studies have also elucidated a medicinal role for RA, especially in regard to its anti-oxidant, and anti-inflammatory activities [12,13]. Furthermore, an emerging body of literature has also described the growth inhibitory and anti-invasion properties of RA in colon, skin, breast and ovarian cancers in vitro and/or in vivo [14][15][16][17][18][19], but the mechanisms underlying these effects are poorly understood. A chemopreventive role for RA in HNSCC has been described in 7,12-dimethylbenz (a) anthracene-induced hamster buccal pouch carcinogenesis [20], but a chemotherapeutic role for RA in the treatment of HNSCC has not yet been reported.Given the anti-oxidant properties attributed to RA, it is possible that RA's anti-tumor effects stem from its ability to combat oxidative stress in HNSCC. Oxidative ...

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“…Starska et al (85) emphasized EGFR mutations as a regulator of SIP to SIP/SCC. Variations in the EGFR gene have been identified as a key factor that are associated with poor prognosis in head and neck squamous cell carcinoma (102). It is likely that EGFR may be a target for SIP treatment; however further studies are required to confirm this hypothesis.…”

Section: Potential Mechanisms Underlying the Recurrence And Malignantmentioning

confidence: 99%

Advances in recurrence and malignant transformation of sinonasal inverted papillomas

Sun

Zheng

et al. 2017

Oncology Letters

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Abstract. Sinonasal inverted papilloma (SIP) is a benign tumor of the nasal cavity and sinus. SIP is characterized by aggressive malignant transformation and a high rate of recurrence. Inadequate removal of the tumor during surgery is one of the most significant contributors to SIP recurrence. A growing body of evidence suggests that molecular alteration in SIP, including human papilloma virus infections, single nucleotide polymorphisms of key genes, deregulation of signaling pathways and immunological changes, may lead to SIP occurrence and malignant transformation. However, the extent to which these molecular mechanisms contribute to SIP pathology and transformation remains unclear due to limited research. Further studies are warranted to elucidate the primary dependent factors that contribute to SIP etiology. The present article reviewed risk factors of progression and recurrence of SIP, including outdoor and industrial occupational exposure, smoking, septal deviation, SIP location, recurrent cases, stage of SIP-associated squamous cell carcinoma and choice of surgical method.

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Epidermal growth factor receptor targeted therapy of squamous cell carcinoma of the head and neck

Cited by 114 publications

References 56 publications

Spheroid-based 3D Cell Cultures Enable Personalized Therapy Testing and Drug Discovery in Head and Neck Cancer

Spheroid-based 3D Cell Cultures Enable Personalized Therapy Testing and Drug Discovery in Head and Neck Cancer

Rosmarinic Acid Inhibits Cell Growth and Migration in Head and Neck Squamous Cell Carcinoma Cell Lines by Attenuating Epidermal Growth Factor Receptor Signaling

Advances in recurrence and malignant transformation of sinonasal inverted papillomas

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