“…In mammals, the EGFR family consists of four members, EGFR (or ErbB1), HER2 (or ErbB2/neu), HER3 (or ErbB3) and ErbB4 which are able to bind multiple peptide ligands (EGF, TGFa, amphiregulin, NDF, neuregulins, heregulins, HB-EGF, betacellulin and epiregulin) and, subsequently, to form homo-and heterodimeric complexes (Riese & Stern, 1998;Moghal & Sternberg, 1999;Hackel et al, 1999). Beside ligand-induced activation, EGFR can also be activated through ligandindependent mechanisms, for instance upon exposure of cells to ultraviolet radiations, oxidants, alkylating agents (Hackel et al, 1999) and oxidized lipids (Suc et al, 1998).…”