Epidermal Integrin α3β1 Regulates Tumor-Derived Proteases BMP-1, Matrix Metalloprotease-9, and Matrix Metalloprotease-3

Abstract

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The characteristics and the multiple functions of integrin β1 in human cancers

“…Numerous studies have demonstrated that integrin α3β1 supported the motility and invasion of thyroid papillary cancer cells and was involved in tumor progression [ 65 ]. Moreover, integrin α3β1 is implicated in regulating tumor-derived proteases bone morphogenetic protein 1, matrix metalloproteinase-9, and matrix metalloproteinase-3 in the secretome of epidermal tumors, making it a potential therapeutic target [ 66 ]. Additionally, integrin α3β1 on keratinocytes facilitates the secretion of IL-1α and exerts paracrine regulation of fibroblast gene expression and differentiation [ 67 ].…”