Epidermal repair in chronic venous ulcers

Adair, H. M.

doi:10.1002/bjs.1800641113

Cited by 31 publications

(15 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The dermal-epidermal junction takes on a very convoluted appearance, with prominent rete ridges, and substantial vascular ingrowth, which takes on a glomerular appearance, into the dermal papillae. [102][103][104] Galkowska et al 105 reported that keratinocyte and dermal vascular endothelial cell capacities remain unimpaired in the margin of chronic venous ulcer, as determined by the expression of growth factors and cytokines at generally a higher level than more distant skin. Andriessen et al 104 showed by immunolocalization of cell proliferation antigens that wound edge keratinocyte proliferation remains unimpaired.…”

Section: Characteristics Of Peri-ulcer Tissuementioning

confidence: 99%

Recent insights into the causes of chronic leg ulceration in venous diseases and implications on other types of chronic wounds

Chen

Rogers

2007

Wound Repair Regeneration

105

View full text Add to dashboard Cite

Venous ulceration represents the most prevalent form of difficult-to-heal wounds and these problematic wounds require a significant amount of healthcare resources for their treatment. In order to develop effective treatment regimens a clearer understanding of the underlying pathological processes that lead to skin breakdown is required. However, to date, most of these studies have tended to focus on describing the pathology of already-established ulcers. By bringing together relevant aspects of diverse disciplines such as inflammation, cardiovascular, and connective tissue biology, we aim to provide an insight into how circulatory abnormalities that are caused by the underlying disease etiology can induce local tissue inflammation resulting in tissue breakdown. Initially this results in internal tissue damage but if the underlying disease is not treated, the internal tissue damage can worsen and lead to open ulceration. This article discusses the cause-and-effect relationships between chronic venous insufficiency and venous ulceration, focusing particularly on the biological processes that lead from the underlying disease condition to overt ulceration. Available evidence also suggests that formation of pressure, diabetic foot and arterial ulcers, and ulcers as results of blood disorders, is also likely to share some of the same biological processes as venous ulcers.

show abstract

Section: Characteristics Of Peri-ulcer Tissuementioning

confidence: 99%

Recent insights into the causes of chronic leg ulceration in venous diseases and implications on other types of chronic wounds

Chen

Rogers

2007

Wound Repair Regeneration

105

View full text Add to dashboard Cite

show abstract

“…So called ''non-healing'' ulcers, such as diabetic, venous, and pressure ulcers, are still challenging problems for clinicians [9,10]. Although many treatments, including reconstructive surgery and wound application, have succeeded in reducing the number of such patients, many still have incurable ulcers.…”

Section: Introductionmentioning

confidence: 99%

Effectiveness of short-contact topical tretinoin in promoting wound healing in db/db mice

Toyama

Ohura

Kurita

et al. 2006

Scandinavian Journal of Plastic and Reconstructive Surgery and

View full text Add to dashboard Cite

We have investigated the effects of short-contact topical application of tretinoin using 16 male db/db mice by creating two full-thickness wounds on the skin of the back. A 0.1% tretinoin aqueous gel was applied to one wound for five minutes daily for five successive days while only aqueous gel was applied to the other (control). The mean (SD) percentage surface area unhealed before and after treatment were 0.88 (0.3) and 0.64 (0.15). In tretinoin-treated mice and non-treated mice (controls), the mean (SD) thicknesses of granulation were 1.383 (697) micro m and 683 (413) micro m, the density of capillary vessels in granulation was 12.2 (5.5)% and 5.7 (3.9)%, respectively. Differences between the two groups were significant for each variable. Wound healing was accelerated with short-contact topical application of tretinoin in db/db mice.

show abstract

“…They can be defined as a wound that is not continuously progressing toward healing 9 or not healing in a methodical and timely fashion 8 . Pathologically, one of the clearest indicators of a chronic wound is their failure to re-epithelialize 10 . The aging population are among those most burdened with chronic wounds, and with low keratinocyte cell turnover, this is a factor affecting their ability to re-epithelialize 11 .…”

Section: Main Textmentioning

confidence: 99%

MicroRNA as Therapeutic Targets for Chronic Wound Healing

Mulholland

Dunne

McCarthy

2017

Molecular Therapy - Nucleic Acids

106

View full text Add to dashboard Cite

Wound healing is a highly complex biological process composed of three overlapping phases: inflammation, proliferation, and remodeling. Impairments at any one or more of these stages can lead to compromised healing. MicroRNAs (miRs) are non-coding RNAs that act as post-transcriptional regulators of multiple proteins and associated pathways. Thus, identification of the appropriate miR involved in the different phases of wound healing could reveal an effective third-generation genetic therapy in chronic wound care. Several miRs have been shown to be upregulated or downregulated during the wound healing process. This article examines the biological processes involved in wound healing, the miR involved at each stage, and how expression levels are modulated in the chronic wound environment. Key miRs are highlighted as possible therapeutic targets, either through underexpression or overexpression, and the healing benefits are interrogated. These are prime miR candidates that could be considered as a gene therapy option for patients suffering from chronic wounds. The success of miR as a gene therapy, however, is reliant on the development of an appropriate delivery system that must be designed to overcome both extracellular and intracellular barriers.

show abstract

Epidermal repair in chronic venous ulcers

Cited by 31 publications

References 15 publications

Recent insights into the causes of chronic leg ulceration in venous diseases and implications on other types of chronic wounds

Recent insights into the causes of chronic leg ulceration in venous diseases and implications on other types of chronic wounds

Effectiveness of short-contact topical tretinoin in promoting wound healing in db/db mice

MicroRNA as Therapeutic Targets for Chronic Wound Healing

Contact Info

Product

Resources

About