Epidermodysplasia verruciformis associated with HPV 10

Acquired epidermodysplasia verruciformis: clinical presentation and treatment update

“…Higher magnification of the altered keratinocytes reveal purple‐blue cytoplasm, variable sized keratohyalin granules, enlarged round nuclei with pale chromatin, and one or multiple small nucleoli 31 . In situ hybridization to HPV types 2, 5, 6, 8, 11, 16, 18, 30, 31, 33, 35, 42, 43, 44, 45, 51, 52, 68, and 70 is one common HPV typing series 32 …”

“…31 35 Merkel cell polyomaviruses (MCPyV) have also been reported in association with AEV. 32 Bushara et al 14 proposed the need for direct HPV L1 gene sequencing in order to identify the causative HPV type and to identify therapies for specific EV-HPV types. Vicente et al 8 identified high-risk mucosal a-HPV types in AEV lesions in three of five HIV (+) children and b-HPV in the other two HIV (+) children.…”

“…Of all common HPV serotypes, the majority in AEV are beta HPV serotypes, including 8, 9, 12, 14, 15, 17, 19‐23, 25, 36‐38, 47, 80, and 93, with alpha HPV serotypes including 2, 6, 7, 11, 13, 27, 40, 43, 44, 57, and 74 35 . Merkel cell polyomaviruses (MCPyV) have also been reported in association with AEV 32 …”