2008
DOI: 10.1210/en.2007-1679
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Epididymis Expresses the Highest 5′-Deiodinase Activity in the Male Reproductive System: Kinetic Characterization, Distribution, and Hormonal Regulation

Abstract: We characterized the enzymes that catalyze the deiodination of T(4) to T(3) in the male reproductive tract. Testis, epididymis (EPI), seminal vesicles, prostate, bulbourethral glands, spermatozoa, and semen were taken from sexually mature rats (300 g). Iodothyronine 5'-deiodinase (5'-D) activity was quantified by the radiolabeled-iodide-release method. 5'-D activity was 10-fold higher in EPI and semen than in the rest of the tissues. In EPI, semen, and prostate, the enzymatic activity was completely inhibited … Show more

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Cited by 10 publications
(8 citation statements)
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“…The effect of antithyroid drugs including carbimazole on reproductive system was studied in different animals. Anguiano et al [22] reported that the enzymatic activity in epididymis, semen and prostate was completely inhibited by 6-n-propyl-2-thiouracil suggesting that local generation of T 3 could be associated with the development and function of epididymis and spermatozoa maturation. Marty et al [23] found that absolute testes, epididymal, prostate and seminal vesicle weights were decreased by 6-propylthiouracil.…”
Section: Discussionmentioning
confidence: 99%
“…The effect of antithyroid drugs including carbimazole on reproductive system was studied in different animals. Anguiano et al [22] reported that the enzymatic activity in epididymis, semen and prostate was completely inhibited by 6-n-propyl-2-thiouracil suggesting that local generation of T 3 could be associated with the development and function of epididymis and spermatozoa maturation. Marty et al [23] found that absolute testes, epididymal, prostate and seminal vesicle weights were decreased by 6-propylthiouracil.…”
Section: Discussionmentioning
confidence: 99%
“…However, studies from our laboratory have shown a strong association between D1 activity and local T 3 generation in tissues of the male reproductive system, such as the epididymis and prostate gland. In both tissues, D1 activity is present at the onset of puberty and sexual maturity [17,18]. In non-sexually active males, we have found that the prostate T 3 concentration decreases with age, but long-term (1 and 5 months) continuation of sexual activity prevents the age-related decline [19].…”
Section: Introductionmentioning
confidence: 67%
“…The possibility that the D1 enzyme is expelled in seminal fluid is supported by the facts that the prostate gland exhibits an apocrine and merocrine secretion and that the number of aposomes is significantly elevated in sexually active males [37,38]. We have reported D1 activity in semen [18], but additional studies are required to assess the effect of sexual activity in this compartment.…”
Section: Discussionmentioning
confidence: 89%
See 1 more Smart Citation
“…Although the enzymes deiodinase 1 (D1) and deiodinase 3 (D3), which inactivate T 4 and T 3 by converting them to their reverse T 3 (rT 3 ) and 3,3′-T 2 forms, respectively, exist in prepubertal and pubertal rat testis [3,47], there are no reports concerning the effect of rT 3 in the testis or in Sertoli cells. Thus, as far as we are aware, this is the first demonstration of the rapid response of rat Sertoli cells in relation to calcium uptake by rT 3 .…”
Section: Discussionmentioning
confidence: 99%