Epidural lipomatosis and renal transplantation

Severity of presentation is associated with time to recovery in spinal epidural lipomatosis

“…This suggested that not just the dose of steroids but also the duration of pharmacotherapy may have significance. Tobler et al noted that while the relationship of lipomatosis to exogenous steroids had been demonstrated, the necessary dose or duration of exposure was not clear [28]. Using periodic CT scans, one study demonstrated that the thickness of epidural fat mirrored the dose of steroids [22].…”

“…In 22 patients, both the cumulative dose of prednisone and the extent of ultimate recovery could be assessed [7,8,10,11,13,14,17,18,20,[22][23][24][26][27][28][29][30]. Five of these patients were managed conservatively with reduction of their steroid dose, 13 were managed with surgery alone and four were managed with both surgery and steroid reduction.…”

“…4). In 16 of the patients treated surgically, there was sufficient description in the reports to analyze both the cumulative dose of prednisone and the timing of postoperative recovery [6][7][8]10,11,18,20,[22][23][24][26][27][28][29]. The timing of recovery was graded as either delayed or rapid.…”

“…In the 17 surgical patients with available data, the time course of patients' neurological deterioration was noted in days [6][7][8]10,11,13,14,17,18,20,23,24,[26][27][28][29][30][32][33][34]36,37]. The duration of symptoms refers to the period of time between when the patient first reported noticing symptoms and their definitive surgery.…”

An unusual complication of morbid obesity: epidural lipomatosis

“…Neurologic deficits may present as compressive myelopathy, radiculopathy, and cauda equina [5]. Patients may also complain of muscle weakness, sensory loss, or abnormal reflexes [6]. Onset is usually a slow progression of neurologic features over several months, although rapid onset and relapsing and remitting courses with sensory symptoms have also been reported [7].…”