Epidural sufentanil for postoperative pain relief

Donadoni, R.; Rolly, G; Noorduin, H.; Bussche, G. Vanden

doi:10.1111/j.1365-2044.1985.tb10939.x

Cited by 57 publications

(16 citation statements)

References 7 publications

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“…The subjective assessment of pain by patient numerical score and objective method of nurse pain score suggested a similar quality of analgesia in the two groups in our study. Duration of analgesia after a 50-pg lumbar epidural sufentanil bolus is quoted at 4 and 5.4 h after upper abdominal surgery and 6.7 h after lower extremity orthopedic procedures (9,11,13). This tallies with our findings, where the slight recurrence of pain at 8 h extending to 24 h in the sufentanil group was almost certainly due to an inadequate infusion rate.…”

Section: Resultssupporting

confidence: 87%

“…The rapid onset of analgesia using a bolus of 50 pg epidural sufentanil is consistent with other series (9)(10)(11). For morphine, analgesia after 6 h is the same in lumbar as in thoracic epidurals, due to migration of epidural morphine to thoracic regions (12).…”

Section: Resultsmentioning

confidence: 62%

“…Sedation is a well-known side effect of epidural sufentanil (9,13). The insignificant difference between the two groups with respect to this feature is noteworthy.…”

Section: Resultsmentioning

confidence: 93%

“…Although there have been no reported cases of delayed respiratory depression after epidural sufentanil, the quoted incidence of early respiratory depression varies. Moderate decreases in respiratory rate and increases in arterial carbon dioxide tension in the first hour after epidural injection of sufentanil (15-75 pg) have been noted in 20 patients (9). It was concluded that respiratory depression was not evident.…”

Section: Resultsmentioning

confidence: 96%

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Postoperative Pain Control With a Continuous Infusion of Epidural Sufentanil in the Intensive Care Unit

Dyer

Anderson²,

Michell³

et al. 1990

Anesthesia & Analgesia

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A prospective, randomized, double-blind trial was conducted to compare the analgesic actions and side effects of sufentanil continuously infused (5 micrograms/h) into the lumbar epidural space (L2-3) with those of an infusion of lumbar epidural morphine (0.5 mg/h). Forty patients admitted to an intensive care unit after elective major abdominal surgery participated over a varying period of 24-40 h. Post-operative pain was treated with an epidural bolus of either sufentanil (50 micrograms) or morphine (5 mg), followed by a continuous infusion of the same opiate. The quality of pain relief was similar in each group. The sufentanil group had a more rapid onset of analgesia. The incidence of nausea and vomiting, pruritus, and drowsiness was similar in the two groups. In spontaneously breathing patients there were no respiratory complications requiring treatment. Forced vital capacities were statistically significantly better during the first 1-4 h with sufentanil.

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Section: Resultssupporting

confidence: 87%

Section: Resultsmentioning

confidence: 62%

“…Sedation is a well-known side effect of epidural sufentanil (9,13). The insignificant difference between the two groups with respect to this feature is noteworthy.…”

Section: Resultsmentioning

confidence: 93%

Section: Resultsmentioning

confidence: 96%

See 2 more Smart Citations

Postoperative Pain Control With a Continuous Infusion of Epidural Sufentanil in the Intensive Care Unit

Dyer

Anderson²,

Michell³

et al. 1990

Anesthesia & Analgesia

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show abstract

“…88 The degree of sedation appears to be related to the dose of opioid administered. 30,49 Central nervous system depression may be profound and coma has been described.…”

Section: Respiratory Depressionmentioning

confidence: 99%

Side effects of intrathecal and epidural opioids

1995

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Use of Patient-Controlled Analgesia for Management of Acute Pain

White

1988

JAMA

181

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Patient-controlled analgesia (PCA) provides improved titration of analgesic drugs, thereby minimizing individual pharmacokinetic and pharmacodynamic differences. Patient-controlled analgesia decreases patient anxiety resulting from delays in receiving pain-relieving medication and from the slow onset of analgesic action when these drugs are administered either intramuscularly or in the extradural space. With PCA therapy, patients are reportedly able to maintain a near optimal state of analgesia with minimal sedation and few side effects. The potential for overdose can be minimized if small bolus doses are used with a mandatory lockout interval between successive doses. Finally, studies of the cost-effectiveness of PCA therapy are important if this therapeutic approach is to achieve more widespread acceptance.

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Epidural sufentanil for postoperative pain relief

Abstract: Summary

Cited by 57 publications

References 7 publications

Postoperative Pain Control With a Continuous Infusion of Epidural Sufentanil in the Intensive Care Unit

Postoperative Pain Control With a Continuous Infusion of Epidural Sufentanil in the Intensive Care Unit

Side effects of intrathecal and epidural opioids

Use of Patient-Controlled Analgesia for Management of Acute Pain

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