Epigallocatechin-3-gallate Alleviates Vanadium-Induced Reduction of Antioxidant Capacity via Keap1-Nrf2-sMaf Pathway in the Liver, Kidney, and Ovary of Laying Hens

Ma, Yan; Shi, Yizhen; Wu, Qiujue; Ma, Wenfeng

doi:10.1007/s12011-020-02398-z

Cited by 17 publications

(11 citation statements)

References 35 publications

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“…Wang et al reported that EGCG partially improved the antioxidant system in vanadium-challenged hens [ 11 ]. Moreover, previous studies of broilers subjected to cyclic chronic HS found that dietary EGCG supplementation can effectively improve growth performance, antioxidant capacity, and the expression of nuclear factor erythroid 2-related 2 ( Nrf2 ) in liver and jejunum, kidney, and ovary [ 12 , 13 , 14 ]. Nevertheless, there exists no report on the effect and mechanism of action of EGCG on meat quality and antioxidant function in broilers under AHS.…”

Section: Introductionmentioning

confidence: 99%

Effects of Dietary Supplementation with Epigallocatechin Gallate on Meat Quality and Muscle Antioxidant Capacity of Broilers Subjected to Acute Heat Stress

Zhao

Wang

et al. 2021

Animals

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This study evaluated epigallocatechin gallate’s (EGCG’s, 400 mg/kg) effect on meat quality and muscle antioxidant status of broilers under acute heat stress (AHS). A total of 144 21-day-old male Huainan partridge chickens were randomly allocated to the EGCG-free group (12 replicates) and the EGCG group (6 replicates). On day 94, the EGCG-free group was divided into the control group (CON) and the AHS group, and then AHS group and EGCG group (identified as AHS + EGCG group) were treated with AHS (33 ± 1 °C for 12 h). AHS increased (p < 0.05) L*24h, drip loss, muscle lactic acid, malondialdehyde (MDA) contents, and kelch-like ECH-associated protein 1 (Keap1) mRNA level, and decreased (p < 0.05) eviscerated percentage, pH24h, a*, muscle total superoxide dismutase (T-SOD) activity, the ratio of T-SOD/MDA and glutathione peroxidase /MDA, glycogen content, and nuclear factor erythroid 2-related 2 (Nrf2), catalase (CAT), NAD(P)H/quinone dehydrogenase 1 (NQO1) mRNA levels. The AHS + EGCG group exhibited lower (p < 0.05) L*24h, drip loss, muscle lactic acid, MDA contents and Keap1 mRNA level, and greater (p < 0.05) eviscerated percentage, pH24h, a*, muscle T-SOD activity, the ratio of T-SOD/MDA, Nrf2, and NQO1 mRNA levels compared with the AHS group. In conclusion, EGCG protects against AHS-impaired meat quality by improving muscle antioxidant capacity, which seems to be associated with the activation of the Nrf2 signaling pathway.

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Section: Introductionmentioning

confidence: 99%

Effects of Dietary Supplementation with Epigallocatechin Gallate on Meat Quality and Muscle Antioxidant Capacity of Broilers Subjected to Acute Heat Stress

Zhao

Wang

et al. 2021

Animals

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“…58 It has been well demonstrated that V 5+ exposure could upregulate the intracellular Keap1 and promote Nrf2 degradation, leading to the reduction of antioxidant capacity. 35,36 Since PMQDs were enriched with V 5+ species, they could perturb the Nrf2/ARE antioxidant mechanism and downregulate the expression of the downstream antioxidant enzymes of Nrf2 such as NQO1 and HO-1. Additionally, we assessed whether PMQDs could alter the intracellular GSH levels.…”

Section: Resultsmentioning

confidence: 99%

“…33,34 Recent studies have demonstrated that vanadium(V) exposure signicantly reduces the gene expression of Nrf2, thus reducing the cellular antioxidant capacity by reducing the expression of downstream antioxidant enzymes. 35,36 Inspired by the above attractive features, herein we report the preparation of high-efficacy sonodynamic CDs (PMQDs) by using vanadium carbide MXene as the carbon source. Due to the efficient migration/separation of electron-hole pairs and the narrow bandgap, these PMQDs exhibited superior US-triggered ROS generating ability compared with that of the classical sonosensitizer, nano-TiO 2 .…”

Section: Introductionmentioning

confidence: 99%

A MXene-derived redox homeostasis regulator perturbs the Nrf2 antioxidant program for reinforced sonodynamic therapy

et al. 2022

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“…In normal conditions, two common serum enzymes (AST and ALT) only existed in cells because of the barrier function of cell membranes. When tissues (especially the liver) were damaged, excessive oxygen free radicals were generated and invaded the cell membranes that increasing the permeability of the cell membrane, which in turn led to the escape of AST and ALT into the serum ( Ma et al, 2021 ). Ramie ethanol extract could significantly reduce serum TC and LDL-C levels of mice, and significantly increase HDL-C level ( p < 0.05) ( Lee et al, 2014 ).…”

Section: Discussionmentioning

confidence: 99%

Effects of Dietary Ramie Powder at Various Levels on the Production Performance, Serum Biochemical Indices, Antioxidative Capacity, and Intestinal Development of Laying Hens

et al. 2022

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The purpose of this study was to investigate the effects of ramie (0, 3, 6, and 9%) included in diets on production performance, antioxidative capacity, serum biochemical indices, and intestinal development of laying hens. A total of 432 Lohmann commercial laying hens were randomly allotted to one of four dietary treatments and fed for 6 weeks. The results showed that the inclusion of ramie had no negative effects on laying performance, and increased (quadratic, P < 0.05) the laying rate with the highest value in the 6% ramie group. However, ramie content in the diet up to 9% reduced the apparent metabolic energy, dry matter, and organic matter apparent digestibility of laying hens compared with those in the 3% ramie group. The content of high-density lipoprotein (HDL-C) in serum was increased (P < 0.05), but the activity of aspartate aminotransferase (AST) was decreased (P < 0.05) by dietary ramie supplementation. As the dietary ramie level increased, the activity of serum glutathione peroxidase (GSH-Px) was increased quadratically (P < 0.05). Compared with control, 3% ramie group significantly increased (P < 0.01) liver total superoxide dismutase (SOD) activity. Meanwhile, the addition of 3∼6% ramie powder increased (P < 0.05) villus height of jejunum and villus height/crypt depth (V/C) of ileum, which reflected the intestinal promotional effect of ramie powder. In conclusion, ramie in a diet of less than 9% might protect the liver and improve the antioxidative capacity with no detrimental impacts on the laying hens. Moreover, it could promote the intestinal mucosal structure and have a positive impact on the intestine health of the laying hens.

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Epigallocatechin-3-gallate Alleviates Vanadium-Induced Reduction of Antioxidant Capacity via Keap1-Nrf2-sMaf Pathway in the Liver, Kidney, and Ovary of Laying Hens

Cited by 17 publications

References 35 publications

Effects of Dietary Supplementation with Epigallocatechin Gallate on Meat Quality and Muscle Antioxidant Capacity of Broilers Subjected to Acute Heat Stress

Effects of Dietary Supplementation with Epigallocatechin Gallate on Meat Quality and Muscle Antioxidant Capacity of Broilers Subjected to Acute Heat Stress

A MXene-derived redox homeostasis regulator perturbs the Nrf2 antioxidant program for reinforced sonodynamic therapy

Effects of Dietary Ramie Powder at Various Levels on the Production Performance, Serum Biochemical Indices, Antioxidative Capacity, and Intestinal Development of Laying Hens

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