Epigallocatechin 3‐gallate attenuates arthritis by regulating Nrf2, HO‐1, and cytokine levels in an experimental arthritis model

Karataş, Ahmet; Dağlı, Adile Ferda; Orhan, Cemal; Gençoğlu, Hasan; Özgen, Metin; Şahin, Nurhan; Şahin, Kazım; Koca, Süleyman Serdar

doi:10.1002/bab.1860

Cited by 23 publications

(25 citation statements)

References 38 publications

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“…Similar ambiguous results have been reported for EGCG, one of the main catechins in tea extract, that showed beneficial effects in modulating inflammation in animal models of experimental arthritis [2,27] with multiple positive effects on health. However, EGCG, as other phenolic compounds, can induce both antioxidant and pro-oxidant effects.…”

Section: Discussionsupporting

confidence: 78%

Modulation of methotrexate efficacy by green tea polyphenols in rat adjuvant arthritis

et al. 2020

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Highlights-Co-administration of green tea extract and methotrexate (MTX) has been studied in arthritic rats-A green tea extract gradually decreased the effectiveness of MTX on arthritic score-A green tea extract alone and with MTX reduced MCP-1, but counteracted IL-17 only at day 14-A green tea extract inhibited iNOS mRNA and GGT, but in a less extent compared to MTX-Long-term administration of green tea extract may inhibit the therapeutic action of methotrexate 3

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Section: Discussionsupporting

confidence: 78%

Modulation of methotrexate efficacy by green tea polyphenols in rat adjuvant arthritis

et al. 2020

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“…Encountering with EGCG decreased TNF-α and IL-17, elevated SOD, CAT, GPx, reduced MDA and upregulated Nrf2 and HO-1 expression (Karatas et al, 2019). In another in vivo and ex vivo study, EGCG modulated B cell responses and balanced Th1/Th2, attenuated IL-6, TNF-α, IL-1β, and IFN-γ levels, elevated IL-10 levels, increased HO-1 protein, p-Nrf2, and Nrf2 (Min et al, 2015;Leichsenring et al, 2016).…”

Section: Rheumatoid Arthritismentioning

confidence: 91%

New insights into the role of the Nrf2 signaling pathway in green tea catechin applications

Talebi

Farkhondeh

et al. 2021

Phytotherapy Research

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Nuclear factor-erythroid 2-related factor 2 (Nrf2) is a transcriptional signaling pathway that plays a crucial role in numerous clinical complications. Pivotal roles of Nrf2 have been proved in cancer, autoimmune diseases, neurodegeneration, cardiovascular diseases, diabetes mellitus, renal injuries, respiratory conditions, gastrointestinal disturbances, and general disorders related to oxidative stress, inflammation, apoptosis, gelatinolysis, autophagy, and fibrogenesis processes. Green tea catechins as a rich source of phenolic compounds can deal with various clinical problems and manifestations. In this review, we attempted to focus on intervention between green tea catechins and Nrf2. Green tea catechins especially epigallocatechin gallate (EGCG) elucidated the protective role of Nrf2 and its downstream molecules in various disorders through Keap-1, HO-1, NQO-1, GPx, GCLc, GCLm, NF-kB cross-link, kinases, and apoptotic proteins. Subsequently, we compiled an updated expansions of the Nrf2 role as a gate to manage and protect different disorders and feasible indications of green tea catechins through this signaling pathway. The present review highlighted recent evidence-based data in silico, in vitro, and in vivo studies on an outline for future clinical trials.cancer, catechins, epigallocatechin gallate (EGCG), green tea, nuclear factor-erythroid 2-related factor 2 (Nrf2) signaling pathway, oxidative stress, therapeutic effects | INTRODUCTIONEvidence-based researches have indicated that existing phytochemicals in various natural agents serve as protectants or therapeutics with the possession of benefits such as high therapeutic index, low cost, and feasible availability (Leitzmann, 2016). Green tea is a well-known and popular beverage that has been used in a great proportion of the universe's population. Catechins are major polyphenols of green tea most commonly used and have responsibility for its therapeutic applications. Efficacy of green tea catechins combat malignancies and numerous neoplasms, cardiovascular diseases and metabolic syndrome, neurodegeneration, autoimmune complications, kidney and urinary tract obstructions, respiratory tract ailments, digestive system dysfunctions, toxicities, microbial diseases, and oxidative damages have been confirmed in recent studies (Mak, 2012;Zaveri, 2006).Besides the effective roles of polyphenols in the alleviation of mortality and morbidity rates have been proved. In some conditions, dysfunctionalities do not prognoses through utilizing conventional drugs and other routes of treatment may be invasive. Therefore, consuming worthful nutraceuticals such as green tea catechins with their

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“…The anti-inflammatory action of EGCG/GTE also derives by their ability to activate Nrf2 nuclear translocation and HO-1 activity leading to protective effects, in particular, on neuronal cells [ 74 ], in arthritis [ 75 ], and in atherosclerosis [ 76 ].…”

Section: Egcg Molecular Mechanisms That Could Counteract Covid-19 mentioning

confidence: 99%

Protective Effect of Epigallocatechin-3-Gallate (EGCG) in Diseases with Uncontrolled Immune Activation: Could Such a Scenario Be Helpful to Counteract COVID-19?

Menegazzi

Campagnari

Bertoldi

et al. 2020

IJMS

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Some coronavirus disease 2019 (COVID-19) patients develop acute pneumonia which can result in a cytokine storm syndrome in response to Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2) infection. The most effective anti-inflammatory drugs employed so far in severe COVID-19 belong to the cytokine-directed biological agents, widely used in the management of many autoimmune diseases. In this paper we analyze the efficacy of epigallocatechin 3-gallate (EGCG), the most abundant ingredient in green tea leaves and a well-known antioxidant, in counteracting autoimmune diseases, which are dominated by a massive cytokines production. Indeed, many studies registered that EGCG inhibits signal transducer and activator of transcription (STAT)1/3 and nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) transcription factors, whose activities are crucial in a multiplicity of downstream pro-inflammatory signaling pathways. Importantly, the safety of EGCG/green tea extract supplementation is well documented in many clinical trials, as discussed in this review. Since EGCG can restore the natural immunological homeostasis in many different autoimmune diseases, we propose here a supplementation therapy with EGCG in COVID-19 patients. Besides some antiviral and anti-sepsis actions, the major EGCG benefits lie in its anti-fibrotic effect and in the ability to simultaneously downregulate expression and signaling of many inflammatory mediators. In conclusion, EGCG can be considered a potential safe natural supplement to counteract hyper-inflammation growing in COVID-19.

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Epigallocatechin 3‐gallate attenuates arthritis by regulating Nrf2, HO‐1, and cytokine levels in an experimental arthritis model

Cited by 23 publications

References 38 publications

Modulation of methotrexate efficacy by green tea polyphenols in rat adjuvant arthritis

Modulation of methotrexate efficacy by green tea polyphenols in rat adjuvant arthritis

New insights into the role of the Nrf2 signaling pathway in green tea catechin applications

Protective Effect of Epigallocatechin-3-Gallate (EGCG) in Diseases with Uncontrolled Immune Activation: Could Such a Scenario Be Helpful to Counteract COVID-19?

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