(-)-Epigallocatechin-3-Gallate (EGCG) Modulates the Composition of the Gut Microbiota to Protect Against Radiation-Induced Intestinal Injury in Mice

Cai, Shang; Xie, Liwei; Xu, Jiayu; Zhou, Hao; Yang, Chao; Tang, Linfeng; Tian, Ye; Li, Ming

doi:10.3389/fonc.2022.848107

Cited by 14 publications

(11 citation statements)

References 54 publications

(55 reference statements)

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“…According to a rodent study, the green tea polyphenol (−)-epigallocatechin-3-gallate (EGCG) was found to protect against RE by increasing the ratio of Firmicutes/ Bacteroidetes and the abundance of probiotics, thereby reverting gut dysbiosis. 145 Zhang et al found that urolithin A (UroA) improved intestinal cell regeneration, which was primarily accomplished through the restoration of the intestinal bacterial profile. 146 Li et al found that butyrate attenuated RE via the activation of G protein-coupled receptors (GPCRs) and the restoration of the intestinal bacterial composition.…”

Section: Othermentioning

confidence: 99%

“…In recent years, a number of new radiation protection agents have been explored in basic research. According to a rodent study, the green tea polyphenol (−)‐epigallocatechin‐3‐gallate (EGCG) was found to protect against RE by increasing the ratio of Firmicutes/Bacteroidetes and the abundance of probiotics, thereby reverting gut dysbiosis 145 . Zhang et al.…”

Section: Modification Of Gut Microbiota and Re Managementmentioning

confidence: 99%

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Radiation enteropathy‐related depression: A neglectable course of disease by gut bacterial dysbiosis

Liu,

Li,

et al. 2024

Cancer Medicine

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Radiation enteropathy (RE) is common in patients treated with radiotherapy for pelvic–abdominal cancers. Accumulating data indicate that gut commensal bacteria determine intestinal radiosensitivity. Radiotherapy can result in gut bacterial dysbiosis. Gut bacterial dysbiosis contributes to the pathogenesis of RE. Mild to moderate depressive symptoms can be observed in patients with RE in clinical settings; however, the rate of these symptoms has not been reported. Studies have demonstrated that gut bacterial dysbiosis induces depression. In the state of comorbidity, RE and depression may be understood as local and abscopal manifestations of gut bacterial disorders. The ability of comorbid depression to worsen inflammatory bowel disease (IBD) has long been demonstrated and is associated with dysfunction of cholinergic neural anti‐inflammatory pathways. There is a lack of direct evidence for RE comorbid with depression. It is widely accepted that RE shares similar pathophysiologic mechanisms with IBD. Therefore, we may be able to draw on the findings of the relationship between IBD and depression. This review will explore the relationship between gut bacteria, RE, and depression in light of the available evidence and indicate a method for investigating the mechanisms of RE combined with depression. We will also describe new developments in the treatment of RE with probiotics, prebiotics, and fecal microbial transplantation.

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Section: Othermentioning

confidence: 99%

Section: Modification Of Gut Microbiota and Re Managementmentioning

confidence: 99%

Radiation enteropathy‐related depression: A neglectable course of disease by gut bacterial dysbiosis

Liu,

Li,

et al. 2024

Cancer Medicine

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“…For example, epigallocatechin-3-gallate (EGCG; a major catechin in green tea) promotes the growth of beneficial Bacteroides and Bifidobacterium and suppresses the bloom of pathogenic Fusobacterium, Bilophila, and Enterobacteriaceae [186]. Such microbiota-modulating effects of EGCG are noted to protect against colitis [187], high-fat diet-induced obesity [188][189][190], radiation-induced mucositis [191], and Clostridium difficile infection (CDI) [192] in mice. Though how EGCG impacts the microbiota is not well understood, several studies propose that it could be due to the bactericidal effects of EGCG, i.e., (i) generating H2O2 that damages the bacterial cell wall [193,194], (ii) inhibiting bacterial fatty acid and folate biosynthesis [195,196], and (iii) inducing oxidative stress and reactive oxidative species (ROS) formation in susceptible bacteria [197].…”

Section: Dietary Polyphenolsmentioning

confidence: 99%

Crosstalk between Gut Microbiota and Host Immunity: Impact on Inflammation and Immunotherapy

et al. 2023

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Gut microbes and their metabolites are actively involved in the development and regulation of host immunity, which can influence disease susceptibility. Herein, we review the most recent research advancements in the gut microbiota–immune axis. We discuss in detail how the gut microbiota is a tipping point for neonatal immune development as indicated by newly uncovered phenomenon, such as maternal imprinting, in utero intestinal metabolome, and weaning reaction. We describe how the gut microbiota shapes both innate and adaptive immunity with emphasis on the metabolites short-chain fatty acids and secondary bile acids. We also comprehensively delineate how disruption in the microbiota–immune axis results in immune-mediated diseases, such as gastrointestinal infections, inflammatory bowel diseases, cardiometabolic disorders (e.g., cardiovascular diseases, diabetes, and hypertension), autoimmunity (e.g., rheumatoid arthritis), hypersensitivity (e.g., asthma and allergies), psychological disorders (e.g., anxiety), and cancer (e.g., colorectal and hepatic). We further encompass the role of fecal microbiota transplantation, probiotics, prebiotics, and dietary polyphenols in reshaping the gut microbiota and their therapeutic potential. Continuing, we examine how the gut microbiota modulates immune therapies, including immune checkpoint inhibitors, JAK inhibitors, and anti-TNF therapies. We lastly mention the current challenges in metagenomics, germ-free models, and microbiota recapitulation to a achieve fundamental understanding for how gut microbiota regulates immunity. Altogether, this review proposes improving immunotherapy efficacy from the perspective of microbiome-targeted interventions.

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“…Urolithin A (UroA), a metabolite of the ellagitannin gut microbiota, can significantly reduce radiation-induced enterocyte apoptosis and improve the intestinal morphological structure and enterocyte regenerative capacity in irradiated mice [ 172 ]. Cai et al [ 173 ] reported that the green tea polyphenol (-)-epigallocatechin-3-gallate (EGCG) could reverse the intestinal microbiota disorder caused by radiation, such as normalizing the ratio of Firmicutes / Bacteroidetes and increasing the abundance of beneficial bacteria. In addition, EGCG has been proven to alleviate radiation-induced intestinal injury (RIII).…”

Section: Radiotherapy For Cancer Based On the Gut Microbiotamentioning

confidence: 99%

New Insights into the Relationship between Gut Microbiota and Radiotherapy for Cancer

Zuo

et al. 2022

Nutrients

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Cancer is the second most common cause of death among humans in the world, and the threat that it presents to human health is becoming more and more serious. The mechanisms of cancer development have not yet been fully elucidated, and new therapies are changing with each passing day. Evidence from the literature has validated the finding that the composition and modification of gut microbiota play an important role in the development of many different types of cancer. The results also demonstrate that there is a bidirectional interaction between the gut microbiota and radiotherapy treatments for cancer. In a nutshell, the modifications of the gut microbiota caused by radiotherapy have an effect on tumor radiosensitivity and, as a result, affect the efficacy of radiotherapy and show a certain radiation toxicity, which leads to numerous side effects. What is of new research significance is that the “gut-organ axis” formed by the gut microbiota may be one of the most interesting potential mechanisms, although the relevant research is still very limited. In this review, we combine new insights into the relationship between the gut microbiota, cancer, and radiotherapy. Based on our current comprehensive understanding of this relationship, we give an overview of the new cancer treatments based on the gut microbiota.

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(-)-Epigallocatechin-3-Gallate (EGCG) Modulates the Composition of the Gut Microbiota to Protect Against Radiation-Induced Intestinal Injury in Mice

Cited by 14 publications

References 54 publications

Radiation enteropathy‐related depression: A neglectable course of disease by gut bacterial dysbiosis

Radiation enteropathy‐related depression: A neglectable course of disease by gut bacterial dysbiosis

Crosstalk between Gut Microbiota and Host Immunity: Impact on Inflammation and Immunotherapy

New Insights into the Relationship between Gut Microbiota and Radiotherapy for Cancer

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