2008
DOI: 10.1016/j.jnutbio.2007.06.010
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Epigallocatechin-3-gallate inhibits interleukin-1β-induced MUC5AC gene expression and MUC5AC secretion in normal human nasal epithelial cells

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Cited by 22 publications
(35 citation statements)
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“…These results agree with the suppression of MUC2 and MUC5AC expression by dexamethasone in NCI-H292 cells 14 and that of IL-1␤-induced MUC2/5AC expression and mucin production by budesonide. 21,22 Our results also agree with other studies on the suppression of the mucin gene by [6]-gingerol and EGCG. [6][7][8] In a previous study, EGCG on normal human nasal epithelial cells suppressed MUC5AC expression at 50 M in normal human nasal epithelial cells.…”
Section: Discussionsupporting
confidence: 90%
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“…These results agree with the suppression of MUC2 and MUC5AC expression by dexamethasone in NCI-H292 cells 14 and that of IL-1␤-induced MUC2/5AC expression and mucin production by budesonide. 21,22 Our results also agree with other studies on the suppression of the mucin gene by [6]-gingerol and EGCG. [6][7][8] In a previous study, EGCG on normal human nasal epithelial cells suppressed MUC5AC expression at 50 M in normal human nasal epithelial cells.…”
Section: Discussionsupporting
confidence: 90%
“…21,22 Our results also agree with other studies on the suppression of the mucin gene by [6]-gingerol and EGCG. [6][7][8] In a previous study, EGCG on normal human nasal epithelial cells suppressed MUC5AC expression at 50 M in normal human nasal epithelial cells. 6 However, our study used a cell line instead and showed the suppression at 10 M. This can be explained by homeostasis activity of normal cells, which tend to require higher reagent concentrations than in cell lines.…”
Section: Discussionsupporting
confidence: 90%
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“…In context with its effect on mucin expression, EGCG was recently shown to attenuate MUC5AC expression by modulating EGFR signaling in normal human nasal epithelial (NHNE) cells [142]. Further, EGCG was demonstrated to suppress IL-1β induced expression and secretion of MUC5AC via inhibition of the phosphorylation of ERK/MAP kinase and MSK1 [143]. Importantly, Lu et al have shown that EGCG decreased MUC1 expression in hepatocellular carcinoma cells (HepG2) that was associated with reduced invasive potential [144].…”
Section: Natural Products Modulating Mucin Expression: Potential Thermentioning
confidence: 99%
“…One important antiinflammatory mechanism played by polyphenols is the inhibition of eicosanoid generating enzymes, including PLA2, cyclooxygenase and lipoxygenase, thereby reducing the concentration of prostanoids and leukotrienes. Arachidonic acid (AA) is released from membrane phospholipids by PLA2 cleavage, which can be metabolized by cyclooxygenases (COX) into prostaglandins (PGs) and thromboxane A2 (TXA2), or by lipoxygenases (LOX) to hydroperoxyeicosatetraenoic acids (HPETE), hydroxyeicosatetraenoic acids (HETES) and leukotrienes (Lts) (Blanchard et al, 1998;Kim et al, 2008;Tanaka, 1995;Terracciano et al, 2006). Among the polyphenolic compounds, flavonoids are the most common in human diet.…”
Section: Natural Compounds As Inhibitors Of Spla2mentioning
confidence: 99%