Epigallocatechin-3-gallate prevents systemic inflammation-induced memory deficiency and amyloidogenesis via its anti-neuroinflammatory properties

Effect of perinatally supplemented flavonoids on brain structure, circulation, cognition, and metabolism in C57BL/6J mice

“…Taken together, these data suggest that flavanols only have a minor influence on inflammatory processes in a healthy young mouse model. Studies on ageing (AD) and flavanols have shown anti-inflammatory effects of flavanols (Esposito et al, 2014;Lee et al, 2013;Nishizawa et al, 2011;Vauzour, 2013). The qRT-PCR for synaptophysin expression did not demonstrate changes in synaptic plasticity, supporting our findings in the PSD95 staining that flavanols do not affect synaptic plasticity during neurodevelopment.…”

Modulators of amyloid protein aggregation and toxicity: EGCG and CLR01

“…An improvement in memory impairment measured by the passive avoidance [118] and Morris water maze tests also was observed [118,119] In addition to the Aβ-related effects of EGCG, the polyphenol also has mitochondrial restorative properties [47]. Mitochondria from the APP swe /PS1ΔE9 [127] double-transgenic mouse model of AD treated orally with ~37 mg/kg/day EGCG revealed a rescuing effect of EGCG on mitochondrial respiratory rates, mitochondrial membrane potential, reactive oxygen species production, and ATP levels by at least 50% in the hippocampus, cortex, and striatum.…”

“…Three weeks of oral EGCG pre-treatment of a mouse model utilizing intracerebroventricular [118] or IP [119] administration of lipopolysaccharide, a pro-inflammatory agent, to induce Aβ deposition by increasing levels of APP and activities of β-and γ-secretases [118][119][120], showed a dose-dependent decrease in APP and Aβ levels and the activities of the secretases [118,119]. An improvement in memory impairment measured by the passive avoidance [118] and Morris water maze tests also was observed [118,119] In addition to the Aβ-related effects of EGCG, the polyphenol also has mitochondrial restorative properties [47].…”

The Effect of Green Tea Leaf Extract on Spatial Memory Function and Superoxyde Dismutase Enzyme Activity in Mice with D-galactose Induced Dimentia

“…Oxidative stress and inflammation have been shown to play an important role in neurodegenerative disease pathogenesis such as Alzheimer's disease (Crews & Masliah, 2010;Gandhi & Abramov, 2012;Mandel et al, 2008;Miao et al, 2009). Some studies indicate that epigallocatechin-3-gallate (EGCG), main polyphenol in green tea; have antioxidant, antiinflammatory, anticancer, and neuroprotective effect (Lee et al, 2013;YK Lee et al, 2009;Mandel et al, 2008;Miao et al, 2009). However, a study stated that EGCG or green tea extract at a certain dose does not have a significant effect on cognitive function, oxidative stress, or neuroinflammation status (Pu et al, 2007;Flores et al, 2014).…”

“…Some studies show that epigallocatechin-3-gallate (EGCG), the main polyphenol in green tea, have been shown to have antioxidant, anti-inflammatory, anticancer, and neuroprotective activity (Miao et al, 2009;Mandel et al, 2008;Lee et al, 2009;Lee et al, 2013). The studies show that the oral administration of green tea EGCG (2 and 6 mg/kg BW) for 4 weeks significantly improves cognitive ability in mice induced by D-galactose (Miao et al, 2009).…”