Epigallocatechin-3-gallate protects against 1,3-dichloro-2-propanol-induced lipid accumulation in C57BL/6J mice

Lü, Jing; Fang, Baochen; Huang, Yuqin; Tao, Siyu; Sun, Boxing; Guan, Shuang; Jin, Yingli

doi:10.1016/j.lfs.2018.08.007

Cited by 17 publications

(17 citation statements)

References 32 publications

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“…EGCG has strong antioxidant activity and chelates divalent metal ions, such as iron, owing to its special stereochemical structure [ 26 , 27 ]. Studies found that EGCG could regulate the expression of specific active proteins, such as AMP-activated protein kinase (AMPK), and the corresponding signaling pathways, and intervene with cell autophagy and apoptosis [ [28] , [29] , [30] ]. Furthermore, some studies showed that EGCG could protect cardiomyocytes against DIC through anti-apoptotic mechanisms [ [31] , [32] , [33] ].…”

Section: Introductionmentioning

confidence: 99%

Epigallocatechin-3-gallate pretreatment alleviates doxorubicin-induced ferroptosis and cardiotoxicity by upregulating AMPKα2 and activating adaptive autophagy

Wang

Qiao

et al. 2021

Redox Biology

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Section: Introductionmentioning

confidence: 99%

Epigallocatechin-3-gallate pretreatment alleviates doxorubicin-induced ferroptosis and cardiotoxicity by upregulating AMPKα2 and activating adaptive autophagy

Wang

Qiao

et al. 2021

Redox Biology

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“…S Klaus et al showed that EGCG was highly effective and sufficient in combating diet-induced obesity in mice [ 25 ]. Several mechanisms have been proposed to explain the anti-obesity effects of green tea, green tea catechins and EGCG, including the modulation of pancreatic lipase, the inhibition of de novo lipogenesis, the oxidation of fatty acid, and the activation of BAT thermogenesis [ 25 , 26 , 27 , 28 , 29 ]. However, these studies mainly focus on the peripheral tissues, mechanistic details of the CNS regulation underlying these effects remain unclear.…”

Section: Introductionmentioning

confidence: 99%

Effects of (−)-Epigallocatechin Gallate (EGCG) on Energy Expenditure and Microglia-Mediated Hypothalamic Inflammation in Mice Fed a High-Fat Diet

Zhou

Mao

et al. 2018

Nutrients

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Obesity is an escalating global epidemic caused by an imbalance between energy intake and expenditure. (−)-Epigallocatechin-3-gallate (EGCG), the major polyphenol in green tea, has been reported to be conducive to preventing obesity and alleviating obesity-related chronic diseases. However, the role of EGCG in energy metabolism disorders and central nervous system dysfunction induced by a high-fat diet (HFD) remains to be elucidated. The aim of this study was to evaluate the effects of EGCG on brown adipose tissue (BAT) thermogenesis and neuroinflammation in HFD-induced obese C57BL/6J mice. Mice were randomly divided into four groups with different diets: normal chow diet (NCD), normal chow diet supplemented with 1% EGCG (NCD + EGCG), high-fat diet (HFD), and high-fat diet supplemented with 1% EGCG (HFD + EGCG). Investigations based on a four-week experiment were carried out including the BAT activity, energy consumption, mRNA expression of major inflammatory cytokines in the hypothalamus, nuclear factor-kappa B (NF-κB) and signal transducer and activator of transcription 3 (STAT3) phosphorylation, and immunofluorescence staining of microglial marker Iba1 in hypothalamic arcuate nucleus (ARC). Experimental results demonstrated that dietary supplementation of EGCG significantly inhibited HFD-induced obesity by enhancing BAT thermogenesis, and attenuated the hypothalamic inflammation and microglia overactivation by regulating the NF-κB and STAT3 signaling pathways.

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“…EGCG decreased TCs and TGs in mice given 1,3-dichloro-2-propanol (1 mg/kg body weight/day), which is an inducer of oxidative stress. EGCG dramatically increased the expression of phosphorylated AMPK at Thr172 and lowered CD36 expression [45]. CD36 has also been deemed essential for lipoprotein binding at the liver [46].…”

Section: Laboratory Studies and Mechanisms Of Egcg Actionmentioning

confidence: 99%

“…CD36 has also been deemed essential for lipoprotein binding at the liver [46]. Therefore, decreased CD36 expression induced by EGCG may be related to changes in blood lipid profiles [45]. Thus, EGCG inhibition of CD36 via AMPK activation may contribute to its anti-obesity effects [47].…”

Section: Laboratory Studies and Mechanisms Of Egcg Actionmentioning

confidence: 99%

The Beneficial Effects of Principal Polyphenols from Green Tea, Coffee, Wine, and Curry on Obesity

Ohishi

Fukutomi²,

Shoji

et al. 2021

Molecules

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Several epidemiological studies and clinical trials have reported the beneficial effects of green tea, coffee, wine, and curry on human health, with its anti-obesity, anti-cancer, anti-diabetic, and neuroprotective properties. These effects, which have been supported using cell-based and animal studies, are mainly attributed to epigallocatechin gallate found in green tea, chlorogenic acid in coffee, resveratrol in wine, and curcumin in curry. Polyphenols are proposed to function via various mechanisms, the most important of which is related to reactive oxygen species (ROS). These polyphenols exert conflicting dual actions as anti- and pro-oxidants. Their anti-oxidative actions help scavenge ROS and downregulate nuclear factor-κB to produce favorable anti-inflammatory effects. Meanwhile, pro-oxidant actions appear to promote ROS generation leading to the activation of 5′-AMP-activated protein kinase, which modulates different enzymes and factors with health beneficial roles. Currently, it remains unclear how these polyphenols exert either pro- or anti-oxidant effects. Similarly, several human studies showed no beneficial effects of these foods, and, by extension polyphenols, on obesity. These inconsistencies may be attributed to different confounding study factors. Thus, this review provides a state-of-the-art update on these foods and their principal polyphenol components, with an assumption that it prevents obesity.

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Epigallocatechin-3-gallate protects against 1,3-dichloro-2-propanol-induced lipid accumulation in C57BL/6J mice

Cited by 17 publications

References 32 publications

Epigallocatechin-3-gallate pretreatment alleviates doxorubicin-induced ferroptosis and cardiotoxicity by upregulating AMPKα2 and activating adaptive autophagy

Epigallocatechin-3-gallate pretreatment alleviates doxorubicin-induced ferroptosis and cardiotoxicity by upregulating AMPKα2 and activating adaptive autophagy

Effects of (−)-Epigallocatechin Gallate (EGCG) on Energy Expenditure and Microglia-Mediated Hypothalamic Inflammation in Mice Fed a High-Fat Diet

The Beneficial Effects of Principal Polyphenols from Green Tea, Coffee, Wine, and Curry on Obesity

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