(‐)‐epigallocatechin‐3‐gallate reduces experimental colon injury in rats by regulating macrophage and mast cell

Mochizuki, Miyako; Hasegawa, Noboru

doi:10.1002/ptr.2862

Cited by 33 publications

(29 citation statements)

References 11 publications

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“…Rats treated with EGCG prior to ischemia/reperfusion-induced liver injury also had lower hepatic MPO activity that was accompanied by lower LPO levels [42]. Lastly, EGCG was shown to inhibit macrophage chemotaxis as well as decrease the level of histamine [43], which activates inflammatory cells [44]. Collectively, our data support that GTE protects against LPO and liver injury by reducing inflammatory cell infiltration and MPO expression.…”

Section: Discussionmentioning

confidence: 53%

Green tea extract protects against nonalcoholic steatohepatitis in ob/ob mice by decreasing oxidative and nitrative stress responses induced by proinflammatory enzymes

Chung

Park

Manautou

et al. 2012

The Journal of Nutritional Biochemistry

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Oxidative and nitrative stress responses resulting from inflammation exacerbate liver injury associated with nonalcoholic steatohepatitis (NASH) by inducing lipid peroxidation and protein nitration. The objective of this study was to investigate whether the anti-inflammatory properties of green tea extract (GTE) would protect against NASH by suppressing oxidative and nitrative damage mediated by proinflammatory enzymes. Obese mice (ob/ob) and their 5-week-old C57BL6 lean littermates were fed 0%, 0.5% or 1% GTE for 6 weeks (n=12–13 mice/group). In obese mice, hepatic lipid accumulation, inflammatory infiltrates and serum alanine aminotransferase activity were markedly increased, whereas these markers of hepatic steatosis, inflammation and injury were significantly reduced among obese mice fed GTE. GTE also normalized hepatic 4-hydroxynonenal and 3-nitro-tyrosine (N-Tyr) concentrations to those observed in lean controls. These oxidative and nitrative damage markers were correlated with alanine aminotransferase (P<.05; r=0.410–0.471). Improvements in oxidative and nitrative damage by GTE were also associated with lower hepatic nicotinamide adenine dinucleotide phosphate oxidase activity. Likewise, GTE reduced protein expression levels of hepatic myeloperoxidase and inducible nitric oxide synthase and decreased the concentrations of nitric oxide metabolites. Correlative relationships between nicotinamide adenine dinucleotide phosphate oxidase and hepatic 4-hydroxynonenal (r=0.364) as well as nitric oxide metabolites and N-Tyr (r=0.598) suggest that GTE mitigates lipid peroxidation and protein nitration by suppressing the generation of reactive oxygen and nitrogen species. Further study is warranted to determine whether GTE can be recommended as an effective dietary strategy to reduce the risk of obesity-triggered NASH.

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Section: Discussionmentioning

confidence: 53%

Green tea extract protects against nonalcoholic steatohepatitis in ob/ob mice by decreasing oxidative and nitrative stress responses induced by proinflammatory enzymes

Chung

Park

Manautou

et al. 2012

The Journal of Nutritional Biochemistry

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“…Epigallocatechin-3-gallate (EGCG), a catechin of the green tea plant Camellia sinensis , shows strong expanding beneficial effects in studies of diabetes, Parkinson's disease, Alzheimer's disease, stroke, inflammation, obesity, and cancer [42]. EGCG exerts its antioxidant activity via decreasing NO and malondialdehyde (MDA) and increasing SOD and ameliorates mucosal inflammation by inhibiting the production of TNF- α , IFN- γ , and NF- κ B. EGCG reduces experimental colon injury by inhibiting macrophage chemotaxis toward N-formyl-L-leucyl-L-phenylalanine, thereby suppressing the mast cells and macrophage activities [43]. Naringenin is another important flavonoids present in AaEE.…”

Section: Discussionmentioning

confidence: 99%

Protective Effect ofAmphipterygium adstringensExtract on Dextran Sulphate Sodium-Induced Ulcerative Colitis in Mice

Rodriguez-Canales

Jimenez-Rivas

Canales-Martínez

et al. 2016

Mediators of Inflammation

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Amphipterygium adstringens is an endemic species in Mexico commonly known as “cuachalalate.” Healers to treat gastritis, gastric ulcers, and gastrointestinal cancer have traditionally used the bark. We investigated the effects of alcoholic extract of A. adstringens (AaEE) in DSS-induced colitis in mice. The protective effect of AaEE was determined at 200 mg/kg by oral gavage for 10 days. We determine the effect of AaEE on clinical features (disease activity index), antioxidants, anti-inflammatory, and immunomodulatory activities in relation to the activity of SOD, CAT, and GPx, levels of proinflammatory cytokines, and changes both macroscopic and microscopic of the colonic mucosa. AaEE significantly reduced the inflammation of colon and significantly increased SOD and GPx activities. AaEE also significantly decreased TNF-α, IFN-γ, and IL-1β cytokine levels compared to DSS-treated mice and reduced both infiltration of inflammatory cells and the mucosal damage in colon. The results suggested the protective potential of AaEE in DSS-induced colitis and this might be attributed to its phytochemicals compounds that have been found to induce a wide spectrum of activities such as reduction in oxidative stress, suppression of inflammation, modulating numerous signal transduction pathways, and induction of apoptosis. The findings of this study suggest that AaEE has substantial potential for the treatment of inflammatory colitis.

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“…Shirakami et al reported that drinking water containing EGCG was beneficial to the suppression of cancer development in the inflamed colon in mice ( 30 ) . Additionally, the ameliorative effect of EGCG on inflammatory bowel disease has been observed in rats ( 31 ) . These studies adopted drinking water or diet containing 0·01–0·20 % EGCG.…”

Section: Discussionmentioning

confidence: 99%

Effects of dietary fibre and tea catechin, ingredients of the Japanese diet, on equol production and bone mineral density in isoflavone-treated ovariectomised mice

et al. 2012

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Equol is a metabolite of the isoflavone daidzein (Dz) and is produced by the bacterial microflora in the distal intestine and colon. Some epidemiological studies have reported an association between increased equol production and intakes of green tea or dietary fibre, which are ingredients of the standard Japanese diet. We examined the effects of a diet supplemented with Dz and tea catechin or dietary fibre on equol production and bone mineral density in ovariectomised (OVX) mice. Female mice of the ddY strain were either sham operated or OVX. OVX mice were fed a control diet, a 0·1 % Dz-supplemented diet or a 0·1 % Dz diet supplemented with one of the food components commonly consumed in the Japanese diet. The mice were given 1 % tea catechin (w/w) as part of the diet in Expt 1 or 5 % polydextrose (PD) and 5 % raffinose (Raf) (w/w) as part of the diet in Expt 2. Catechin reduced serum equol levels and attenuated the beneficial effect of Dz on femoral bone loss. The soluble dietary fibres PD and Raf stimulated equol production, and enhanced the bone-protective effects of Dz on femoral bone. These results suggest that dietary fibre, in particular, PD, may alter the bioavailability of isoflavones and prevent osteopenia in OVX mice.

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(‐)‐epigallocatechin‐3‐gallate reduces experimental colon injury in rats by regulating macrophage and mast cell

Cited by 33 publications

References 11 publications

Green tea extract protects against nonalcoholic steatohepatitis in ob/ob mice by decreasing oxidative and nitrative stress responses induced by proinflammatory enzymes

Green tea extract protects against nonalcoholic steatohepatitis in ob/ob mice by decreasing oxidative and nitrative stress responses induced by proinflammatory enzymes

Protective Effect ofAmphipterygium adstringensExtract on Dextran Sulphate Sodium-Induced Ulcerative Colitis in Mice

Effects of dietary fibre and tea catechin, ingredients of the Japanese diet, on equol production and bone mineral density in isoflavone-treated ovariectomised mice

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