Epigallocatechin gallate affects human dendritic cell differentiation and maturation

Yoneyama, Satomi; Kawai, Kazushige; Tsuno, Nelson H.; Okaji, Yurai; Asakage, Masahiro; Tsuchiya, Takeshi; Yamada, Jun; Sunami, Eiji; Osada, Takuya; Kitayama, Joji; Takahashi, Koki; Nagawa, Hirokazu

doi:10.1016/j.jaci.2007.08.026

Cited by 67 publications

(45 citation statements)

References 41 publications

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“…15,42 In a co-culture study, 42 separately treating either APCs (during the antigen ovalbumin pulse) or T cells (ovalbumin specific) with EGCG-reduced T-cell proliferation, however, the direct effect of EGCG on T cells was predominant. Together with the previous studies showing that in vitro supplementation of EGCG suppressed maturation of mouse bone marrow-derived 43 and human monocyte-derived 44 dendritic cells, we believe that, although T cells are the main target of EGCG effect, contribution of APCs to EGCGinduced inhibition of autoreactive T-cell proliferation should be considered. More directed, definitive work is needed to accurately elucidate this question.…”

Section: Discussionsupporting

confidence: 64%

Epigallocatechin-3-Gallate Ameliorates Experimental Autoimmune Encephalomyelitis by Altering Balance among CD4+ T-Cell Subsets

Wang

Ren

et al. 2012

The American Journal of Pathology

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The green tea component epigallocatechin-3-gallate (EGCG) may be beneficial in autoimmune diseases; however, the underlying mechanisms are not well understood. In this study, we determined the effect of EGCG on the development of experimental autoimmune encephalomyelitis, an animal model for human multiple sclerosis, and the underlying mechanisms. Female C57BL/6 mice were fed EGCG (0%, 0.15%, 0.3%, and 0.6% in diet) for 30 days and then immunized with specific antigen myelin oligodendrocyte glycoprotein 35-55. EGCG dose dependently attenuated clinical symptoms and pathological features (leukocyte infiltration and demyelination) in the central nervous system and inhibited antigen-specific T-cell proliferation and delayed-type hypersensitivity skin response. We further showed that EGCG reduced production of interferon-␥, IL-17, IL-6, IL-1␤, and tumor necrosis factor-␣; decreased types 1 and 17 helper T cells (Th1 and Th17, respectively); and increased regulatory T-cell populations in lymph nodes, the spleen, and the central nervous system. Moreover, EGCG inhibited expression of transcription factors T-box expressed in T cells and retinoid-related orphan receptor-␥t, the specific transcription factor for Th1 and Th17 differentiation, respectively; the plasma levels of intercellular adhesion molecule 1; and CCR6 expression in CD4 ؉ T cells. These results indicate that EGCG may attenuate experimental autoimmune encephalomyelitis autoimmune response by inhibiting immune cell infiltration and modulating the balance among pro-and anti-autoimmune CD4 ؉ T-cell subsets.Thus, we identified a novel mechanism that underlies EGCG's beneficial effect in autoimmune disease. (Am J

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Section: Discussionsupporting

confidence: 64%

Epigallocatechin-3-Gallate Ameliorates Experimental Autoimmune Encephalomyelitis by Altering Balance among CD4+ T-Cell Subsets

Wang

Ren

et al. 2012

The American Journal of Pathology

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“…The immunomodulatory activity of quercetin has been investigated in NK cells (17), macrophages (18), mast cells (19), neutrophils (20), B cells (21), and T cells (22). Although a number of studies have reported the activity of flavonoids in the modulation of DC activation (23)(24)(25)(26)(27), the effect of quercetin on DCs remains unknown. In this study, we examined the immunomodulatory effect of quercetin on DC activation.…”

mentioning

confidence: 99%

Immunosuppressive Effect of Quercetin on Dendritic Cell Activation and Function

Huang

Cheng

et al. 2010

The Journal of Immunology

173

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“…It has shown inhibitory effects on human monocyte-derived DCs (dendritic cells) and, consequently, on the T-cell-mediated immune responses 86 . Cartilage-preserving and chondroprotective action of EGCGs, its mechanisms and beneficial effects in arthritis have been reported through various studies 87 .…”

Section: Camellia Sinensis (Theaceae)mentioning

confidence: 99%

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2013

IJPSR

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Arthritis is still a challenge for medical research. Pharmaceutical research has resulted in several new approaches for treatment/management of arthritis including drugs like the biologic disease modifying anti-rheumatic drugs (DMARDs). Several disadvantages like serious side effects, high costs and requirement of parenteral administration still invite more research in this area to provide a convenient, affordable therapy with lesser or no side effects. Traditionally used herbal medicines, due to their anti-inflammatory and immunomodulatory properties, have potential to be a therapy of choice for arthritis patients and are now extensively being studied. Although a number of these medicines are being used traditionally for their therapeutic activity, development of their novel drug delivery systems was not attractive to the scientists due to insufficient knowledge about their exact mechanism of action and difficulties in processing, standardising, extracting and identification of active constituents. Current research demonstrates that the effectiveness and bioavailability of herbal actives can be improved by understanding of exact mechanism of action and by formulating them into novel technologies like liposomes, phytosomes and transdermal drug delivery. The present review focuses on herbal medicines for arthritis along with various strategies adopted by scientists so as to improve the bioavailability, stability and to reduce the side effects of these medicines so as to provide consistently effective alternative medication for arthritis. The strategies include understanding mechanisms of their action, enhancing solubilities of poorly soluble actives and developing novel drug delivery systems of these herbal medicines.

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Epigallocatechin gallate affects human dendritic cell differentiation and maturation

Cited by 67 publications

References 41 publications

Epigallocatechin-3-Gallate Ameliorates Experimental Autoimmune Encephalomyelitis by Altering Balance among CD4+ T-Cell Subsets

Epigallocatechin-3-Gallate Ameliorates Experimental Autoimmune Encephalomyelitis by Altering Balance among CD4+ T-Cell Subsets

Immunosuppressive Effect of Quercetin on Dendritic Cell Activation and Function

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