(−)-Epigallocatechin gallate/gelatin layer-by-layer assembled films and microcapsules

Shutava, Tatsiana G.; Balkundi, Shantanu; Lvov, Yuri

doi:10.1016/j.jcis.2008.10.082

Cited by 109 publications

(69 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The encapsulation efficiency of EGCG was determined by reacting with cation radicals of ABTS (ABTS + •). 20 In vitro drug-release measurements were then carried out: 1 mg/mL of concentrated NP suspension from 5 mL NPs with fluorescent dye conjugation (TAMRA) was placed in a dialysis membrane (Spectra/Por dialysis membrane), then soaked into 40 mL of PBS at pH 4 and incubated in a shaker operated at 120 rpm at 37°C. For the free dye test, the same concentration of TAMRA was dissolved in water, then added to the dialysis bag for soaking in acidic PBS.…”

Section: Characterization Of Nps Size Charge and Morphology Of Npsmentioning

confidence: 99%

Preparation of arginine–glycine–aspartic acid-modified biopolymeric nanoparticles containing epigalloccatechin-3-gallate for targeting vascular endothelial cells to inhibit corneal neovascularization

Chang

Wang

Miyagawa

et al. 2016

IJN

View full text Add to dashboard Cite

Section: Characterization Of Nps Size Charge and Morphology Of Npsmentioning

confidence: 99%

Preparation of arginine–glycine–aspartic acid-modified biopolymeric nanoparticles containing epigalloccatechin-3-gallate for targeting vascular endothelial cells to inhibit corneal neovascularization

Chang

Wang

Miyagawa

et al. 2016

IJN

View full text Add to dashboard Cite

“…A similar result was also obtained in the LbL self-assembly of epigallocatechin gallate (EGCG) with gelatin (Type A). 36 A common explanation for the rapid growth of membrane thickness is the "in-and-out" diffusion model. Some molecules involved in the assembly process may not only be absorbed on the film surface but also diffuse into the interior of the film, which can diffuse out of the film in the subsequent deposition step, and then adsorb more molecules on the film surface.…”

Section: ■ Materials and Methodsmentioning

confidence: 99%

Fabrication of Ultrathin Membrane via Layer-by-Layer Self-assembly Driven by Hydrophobic Interaction Towards High Separation Performance

Zhao

Pan

et al. 2013

ACS Appl. Mater. Interfaces

104

View full text Add to dashboard Cite

A novel and facile layer-by-layer (LbL) selfassembly process driven by hydrophobic interaction and then reinforced by hydrogen bond was developed to prepare ultrathin membranes. Gelatin (GE) and tannic acid (TA) were alternately deposited on polyacrylonitrile (PAN) ultrafiltration membranes to obtain GE/TA membranes. The required number of deposition cycles for acceptable permselectivity of membrane was greatly reduced compared with that of the traditional LbL self-assembly process and could be ascribed to the rapid growth of membrane thickness and the integrity of the innermost gelatin layer. Higher surface hydrophilicity and more appropriate free volume characteristics were obtained for GE/TA multilayer membranes compared with pristine gelatin membrane. Moreover, the GE/TA multilayer membrane exhibited improved stability even at high water content of 30 wt %. The membrane separation experiments with pervaporation dehydration of ethanol aqueous solution as a model system demonstrated the GE/TA multilayer membrane achieved higher water permselectivity than the pristine gelatin membrane. High operation stability was acquired in the long-term membrane separation test. KEYWORDS: gelatin/tannic acid, layer-by-layer self-assembly, hydrophobic interaction, hydrogen bond, ultrathin membranes ■ INTRODUCTIONAs a facile method to prepare ultrathin films with tunable thickness, composition, structure, and permeability, layer-bylayer (LbL) self-assembly has received considerable research attention and exhibited prospective applications in realms such as membrane-based separation, 1,2 drug delivery, 3,4 biosensors, 5 and microreactors. 6,7 The most deeply studied driving force for LbL self-assembly is the electrostatic interaction between oppositely charged species (mainly polyelectrolytes). 8,9 In each assembly step, a polyelectrolyte layer is adsorbed on the charged substrate and reverses the surface charge so that in the next assembly step a polyelectrolyte layer with opposite charge can be adsorbed.10 With the development of LbL self-assembly technique, diverse functions and properties are often demanded for multilayer films, which require a broader range of components beyond charged species. As a result, constructing multilayer films on the basis of non-electrostatic interactions such as hydrophobic interaction, 11 hydrogen bond, 12,13 and metal−ligand coordination 6,9 has gained more and more attention. 8 Hydrophobic interaction refers to the interaction formed between hydrophobic groups in an aqueous environment under enthalpy effect and entropy effect, which makes the hydrophobic groups cluster to reduce their exposure to water molecules. Several researches have been carried out to investigate the functions of hydrophobic interaction in LbL self-assembly.14−17 Based on the experimental data and theoretical models, Kotov 15 confirmed that hydrophobic interaction was one of the decisive factors for forming polyelectrolyte multilayers. Furthermore, hydrophobic interaction can promote the assembly of weak polye...

show abstract

“…EGCG in the layer-by-layer assemblies retained its antioxidant activity. Results suggested that the EGCG content in the polyphenol fi lm material was as high as 30 % and these microcapsules protect encapsulated polyphenols against reactive oxygen species thereby prolonging their life and antioxidative effi ciency [ 124 ].…”

Section: Microcapsulesmentioning

confidence: 99%

Nano-encapsulation of a Natural Polyphenol, Green Tea Catechins: Way to Preserve Its Antioxidative Potential

Dang

Gupta

Bansal

et al. 2014

Free Radicals in Human Health and Disease

View full text Add to dashboard Cite

Emanating from extensive research carried out all over the globe, green tea has been acknowledged for plethora of pharmacological activities like anti-infl ammatory, antimicrobial, antitumor, antiaging, and many more. This wide array of health effects have been attributed to green tea catechins (GTCs). These GTCs correspond to the class of antioxidants which scavenge the precarious free radicals in the body and, thus, prevent the progression of various diseases. However, poor bioavailability, short halflife, stability issues, and short shelf life hamper its use as a therapeutic agent. To address these limitations, various encapsulation techniques have been explored by the scientists. The encapsulation techniques employed for green tea and its catechins range from microparticles, microcapsules, nanoparticles, and lipid nanocapsules to self assembly approaches like liposomes, micelles, and microemulsions. Encapsulation not only helps in enhancing the aqueous solubility and stability of the GTCs but also provides for controlled and sustained release thus protecting their biological/ pharmacological activity in systemic circulation. At the same time, sustained release is likely to enhance bioavailability and thus can reduce the likelihood of repeated use. The aim of this chapter is to discuss the role of green tea as an antioxidant and various nano-encapsulation strategies to enhance the effi cacy of related products. It also provides an insight into some of the commercial and patented green tea-based products.

show abstract

(−)-Epigallocatechin gallate/gelatin layer-by-layer assembled films and microcapsules

Cited by 109 publications

References 39 publications

Preparation of arginine–glycine–aspartic acid-modified biopolymeric nanoparticles containing epigalloccatechin-3-gallate for targeting vascular endothelial cells to inhibit corneal neovascularization

Preparation of arginine–glycine–aspartic acid-modified biopolymeric nanoparticles containing epigalloccatechin-3-gallate for targeting vascular endothelial cells to inhibit corneal neovascularization

Fabrication of Ultrathin Membrane via Layer-by-Layer Self-assembly Driven by Hydrophobic Interaction Towards High Separation Performance

Nano-encapsulation of a Natural Polyphenol, Green Tea Catechins: Way to Preserve Its Antioxidative Potential

Contact Info

Product

Resources

About

(−)-Epigallocatechin gallate/gelatin layer-by-layer assembled films and microcapsules

Cited by 109 publications

References 39 publications

Preparation of arginine&ndash;glycine&ndash;aspartic acid-modified biopolymeric nanoparticles containing epigalloccatechin-3-gallate for targeting vascular endothelial cells to inhibit corneal neovascularization

Preparation of arginine&ndash;glycine&ndash;aspartic acid-modified biopolymeric nanoparticles containing epigalloccatechin-3-gallate for targeting vascular endothelial cells to inhibit corneal neovascularization

Fabrication of Ultrathin Membrane via Layer-by-Layer Self-assembly Driven by Hydrophobic Interaction Towards High Separation Performance

Nano-encapsulation of a Natural Polyphenol, Green Tea Catechins: Way to Preserve Its Antioxidative Potential

Contact Info

Product

Resources

About

Preparation of arginine–glycine–aspartic acid-modified biopolymeric nanoparticles containing epigalloccatechin-3-gallate for targeting vascular endothelial cells to inhibit corneal neovascularization

Preparation of arginine–glycine–aspartic acid-modified biopolymeric nanoparticles containing epigalloccatechin-3-gallate for targeting vascular endothelial cells to inhibit corneal neovascularization