Epigallocatechin Gallate-Mediated Alteration of the MicroRNA Expression Profile in 5α-Dihydrotestosterone-Treated Human Dermal Papilla Cells

Shin, Shanghun; Kim, Karam; Lee, Myung J.; Lee, Jeong-Ju; Choi, Sung-Jin; Kim, Kyung-Suk; Ko, Jin Hwan; Han, Hyunjoo; Kim, Su Young; Youn, Hae Jeong; Ahn, Kyu Joong; An, In‐Sook; An, Sungkwan; Jun, Hwa

doi:10.5021/ad.2016.28.3.327

Cited by 28 publications

(18 citation statements)

References 48 publications

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“…Similar results for miR-140-3p were obtained under EGCG treatment in chondrocyte [102]. Furthermore, EGCG induced the increase of miR-3663-3p, miR-1181, miR-3613-3p, miR1281, and miR-1539 and the decrease of miR-221-5p, miR-374b, miR-4306, miR-500a-5p, and miR590-5p in human dermal papilla cells [108] from scalp hair. The sensitivity of the scalp is also higher in migraine, and this latter miR was found downregulated in humans suffering from pain-migraine.…”

Section: Egcg and Micrornassupporting

confidence: 81%

Quercetin, Epigallocatechin Gallate, Curcumin, and Resveratrol: From Dietary Sources to Human MicroRNA Modulation

et al. 2019

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Epidemiologic studies suggest that dietary polyphenol intake is associated with a lower incidence of several non-communicable diseases. Although several foods contain complex mixtures of polyphenols, numerous factors can affect their content. Besides the well-known capability of these molecules to act as antioxidants, they are able to interact with cell-signaling pathways, modulating gene expression, influencing the activity of transcription factors, and modulating microRNAs. Here we deeply describe four polyphenols used as nutritional supplements: quercetin, resveratrol, epigallocatechin gallate (ECGC), and curcumin, summarizing the current knowledge about them, spanning from dietary sources to the epigenetic capabilities of these compounds on microRNA modulation.

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Section: Egcg and Micrornassupporting

confidence: 81%

Quercetin, Epigallocatechin Gallate, Curcumin, and Resveratrol: From Dietary Sources to Human MicroRNA Modulation

et al. 2019

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“…However, Shin et al accidentally discovered a hormetic effect of EGCG with human DPCs in 2016. 27 Unaware of the earlier 2008 report of Li et al, 26 they cited the earlier 2003 report of Chung et al 28 confirming the “concentration-dependent dual function” of EGCG, showing a stimulation of human epidermal keratinocyte proliferation (Figure S3). At the optimal concentration of 10 μM, Shin et al reported that EGCG inhibited DHT-induced cellular senescence and reactive oxygen species (ROS) levels.…”

Section: Resultsmentioning

confidence: 75%

“…At the optimal concentration of 10 mM, Shin et al reported that EGCG inhibited DHTinduced cellular senescence and reactive oxygen species (ROS) levels. 27 Furthermore, the 10-mM EGCG concentration altered DHT effects on MiRNA (ie, 13 upregulated and 40 downregulated effects; Figure S4).…”

Section: Hair Growthmentioning

confidence: 99%

Does Green Tea Induce Hormesis?

et al. 2020

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Green tea, and its principal constituent (–)-epigallocatechin-3-gallate (EGCG), are commonly shown to induce biphasic concentration/dose responses in a broad range of cell types, including non-tumor cells, and tumor cell lines. The most active area of research dealt with an assessment of neural cells with application to neurodegenerative diseases such as Parkinson’s disease and Alzheimer’s disease cell models, often using preconditioning experimental protocols. The general findings demonstrate EGCG-induced hormetic effects resulting in an enhanced acquired resilience within an adaptive and temporally dependent homeodynamic framework. The biphasic dose responses displayed the typical quantitative features of the hormetic dose response with respect to the amplitude and width of the stimulatory response. These findings provide further evidence for the general occurrence of hormetic dose responses with such responses being independent of the biological model, end point, inducing agent, and mechanism. The biphasic nature of these responses has important implications since it suggests optimal dose ranges for end points of public health and therapeutic applications. These findings indicate the need to assess the entire dose-response continuum in order to better define the nature of the dose response, especially in the low-dose zone where such exposures are common in human populations.

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“…Dihydrotestosterone (DHT) is known to induce androgenic alopecia by shortening the hair follicle growth phase, resulting in hair loss. DHT damages DPCs by upregulation of Dickkopf 1 (DKK‐1), induction of cell death, increase in ROS and senescence in DPCs .A variety of compounds have demonstrated protective effect against DHT induced stress in DPCs .…”

Section: Protective Effect In Hair Growth Against Stressmentioning

confidence: 99%

Review of Hair Follicle Dermal Papilla cells asin vitroscreening model for hair growth

Madaan

Verma

Singh

et al. 2018

Intern J of Cosmetic Sci

127

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Hair disorders such as hair loss (alopecia) and androgen dependent, excessive hair growth (hirsutism, hypertrichosis) may impact the social and psychological well-being of an individual. Recent advances in understanding the biology of hair have accelerated the research and development of novel therapeutic and cosmetic hair growth agents. Preclinical models aid in dermocosmetic efficacy testing and claim substantiation of hair growth modulators. The in vitro models to investigate hair growth utilize the hair follicle Dermal Papilla cells (DPCs), specialized mesenchymal cells located at the base of hair follicle that play essential roles in hair follicular morphogenesis and postnatal hair growth cycles. In this review, we have compiled and discussed the extensively reported literature citing DPCs as in vitro model to study hair growth promoting and inhibitory effects. A variety of agents such as herbal and natural extracts, growth factors and cytokines, platelet-rich plasma, placental extract, stem cells and conditioned medium, peptides, hormones, lipid-nanocarrier, light, electrical and electromagnetic field stimulation, androgens and their analogs, stress-serum and chemotherapeutic agents etc. have been examined for their hair growth modulating effects in DPCs. Effects on DPCs' activity were determined from untreated (basal) or stress induced levels. Cell proliferation, apoptosis and secretion of growth factors were included as primary end-point markers. Effects on a wide range of biomolecules and mechanistic pathways that play key role in the biology of hair growth were also investigated. This consolidated and comprehensive review summarizes the up-to-date information and understanding regarding DPCs based screening models for hair growth and may be helpful for researchers to select the appropriate assay system and biomarkers. This review highlights the pivotal role of DPCs in the forefront of hair research as screening platforms by providing insights into mechanistic action at cellular level, which may further direct the development of novel hair growth modulators.

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Epigallocatechin Gallate-Mediated Alteration of the MicroRNA Expression Profile in 5α-Dihydrotestosterone-Treated Human Dermal Papilla Cells

Cited by 28 publications

References 48 publications

Quercetin, Epigallocatechin Gallate, Curcumin, and Resveratrol: From Dietary Sources to Human MicroRNA Modulation

Quercetin, Epigallocatechin Gallate, Curcumin, and Resveratrol: From Dietary Sources to Human MicroRNA Modulation

Does Green Tea Induce Hormesis?

Review of Hair Follicle Dermal Papilla cells asin vitroscreening model for hair growth

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