Epigallocatechin gallate mediated sandwich-like coating for mimicking endothelium with sustained therapeutic nitric oxide generation and heparin release

Zhang, Bo; Yao, Ruijuan; Hu, Cheng; Maitz, Manfred F.; Wu, Haoshuang; Liu, Kunpeng; Yang, Li; Luo, Rifang; Wang, Yunbing

doi:10.1016/j.biomaterials.2020.120418

Cited by 77 publications

(58 citation statements)

References 58 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…EGCG, rich in phenolic hydroxyl groups, worked as the weak cross-linker and imparted intermolecular forces to the coating, such as hydrogen bonds with nanogels and electrostatic interactions with PEI-Tpl. In addition, slightly oxidized EGCG with a small amount of o -quinones could form covalent bonds with primary amines in PEI-Tpl through Michael addition or Schiff base reaction ( 7 , 35 ).…”

Section: Resultsmentioning

confidence: 99%

“…There are myriad reasons for the failure of cardiovascular implant devices. Chief among them are poor endothelialization and hyperplasia ( 6 , 7 ). Rapid and healthy reendothelialization of the surface and inhibited hyperplasia, therefore, are the accepted direction for functional modification of cardiovascular blood-contacting devices.…”

Section: Introductionmentioning

confidence: 99%

“…In the subsequent expansion stage, prothrombin is converted to thrombin and then fibrinogen is converted to fibrin, leading to the eventual formation of clots ( 8 ). To restrain the coagulation after the contact of biomaterials with blood, various anticoagulant substances have been applied on the blood-contacting surfaces ( 9 ), such as anti-adhesive macromolecules ( 10 , 11 ), heparin ( 7 ), and nitric oxide (NO)–releasing coatings ( 12 , 13 ). The working mode of most strategies is open-loop, based on passive diffusion and enzymatic activity, with no feedback regulation.…”

Section: Introductionmentioning

confidence: 99%

“…Since a single function is not sufficient for blood-contacting materials, the anti-inflammatory modification should take into account the combination of anti-inflammatory substances with other functions, especially anticoagulant function. Substances that can interact with other functional molecules without compromising antioxidant activity, such as polyphenols ( 7 , 30 ) and anti–free radical moieties ( 31 ), are preferred.…”

Section: Introductionmentioning

confidence: 99%

“…Those three functional modules were assembled on the basis of the reported sandwiched layer-by-layer (LBL) self-assembly modification ( 7 , 35 ). EGCG with abundant phenolic hydroxyl groups was endowed between PEI-Tpl and nanogels to establish a sandwiched LBL coating and improve the overall performance of the multifunctional coating ( 35 ).…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

A thrombin-triggered self-regulating anticoagulant strategy combined with anti-inflammatory capacity for blood-contacting implants

Wang

Zhou

et al. 2022

Sci. Adv.

Self Cite

View full text Add to dashboard Cite

Interrelated coagulation and inflammation are impediments to endothelialization, a prerequisite for the long-term function of cardiovascular materials. Here, we proposed a self-regulating anticoagulant coating strategy combined with anti-inflammatory capacity, which consisted of thrombin-responsive nanogels with anticoagulant and anti-inflammatory components. As an anticoagulant, rivaroxaban was encapsulated in nanogels cross-linked by thrombin-cleavable peptide and released upon the trigger of environmental thrombin, blocking the further coagulation cascade. The superoxide dismutase mimetic Tempol imparted the antioxidant property. Polyphenol epigallocatechin gallate (EGCG), in addition to its anti-inflammatory function in synergy with Tempol, also acted as a weak cross-linker to stabilize the coating. The effectiveness and versatility of this coating were validated using two typical cardiovascular devices as models, biological valves and vascular stents. It was demonstrated that the coating worked as a precise strategy to resist coagulation and inflammation, escorted reendothelialization on the cardiovascular devices, and provided a new perspective for designing endothelium-like functional coatings.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

A thrombin-triggered self-regulating anticoagulant strategy combined with anti-inflammatory capacity for blood-contacting implants

Wang

Zhou

et al. 2022

Sci. Adv.

Self Cite

View full text Add to dashboard Cite

show abstract

Tissue‐Engineered Vascular Grafts: Emerging Trends and Technologies

Gupta

Mandal

2021

Adv Funct Materials

View full text Add to dashboard Cite

Vascular tissue engineering has made prodigious progress in recent years by converging multidisciplinary approaches. Latest technological advancements foster the development of next‐generation tissue‐engineered vascular grafts (TEVGs) for treating various vasculopathies. While traditional therapeutic methods rely on bypassing the severely damaged vessels with synthetic counterparts with no growth potential, contemporary perspectives focus on biodegradable conduits bestowing an inherent remodeling capability. This review highlights emerging innovative trends and technologies adopted to pragmatically fulfill current scientific needs while improving overall TEVG performance in pre‐clinical and clinical settings. A comprehensive overview of various milestones achieved in the past few decades is first summarized, followed by an appraisal of the significant hurdles for clinical translation. The latest techniques to rationally address critical challenges, viz., intimal hyperplasia, thrombosis, constructive graft remodeling, and adequate neo‐tissue formation are discussed. Finally, an update on ongoing clinical trials is provided and future perspectives required to persuade TEVGs to become a clinical reality are delineated.

show abstract

Precise Regulation of Inflammation and Oxidative Stress by ROS‐Responsive Prodrug Coated Balloon for Preventing Vascular Restenosis

Zhao

Jia

et al. 2023

Adv Funct Materials

View full text Add to dashboard Cite

Vascular restenosis after balloon dilation is largely caused by the over‐proliferation of smooth muscle cells, which is triggered and exacerbated by local excessive inflammation and oxidative stress. The excessive inflammatory and oxidative stress cause tissue/cell damage, hamper endothelial functions, and worsen intimal hyperplasia and restenosis. A high level of reactive oxygen species (ROS) overproduction is regarded as the main culprit. Therefore, efficiently inhibiting ROS over‐production or weightily depleting them is of great significance. Herein, a “ROS‐responsive/scavenging prodrug” is introduced into balloon coating for the treatment of vascular restenosis. A reversible phenylboronic ester‐bearing caffeic acid (CA) macromolecular prodrug (PBC) is designed for the controlled and on‐demand dual‐drug release triggered by the local high ROS level; the released CA and 4‐hydroxybenzyl alcohol exhibit efficient antioxidant and anti‐inflammatory effects by scavenging ROS, thereby regulating vascular microenvironment and protecting endothelium functions. To accelerate endothelium regeneration, pro‐endothelial microRNA‐126 is further introduced. The ROS‐responsive/scavenging prodrug/miRNA balloon coating efficiently prevents intimal hyperplasia, alleviates local inflammation, and improves endothelium healing in a rat abdominal aorta restenosis model, which may provide applicative perspectives for next‐generation drug‐coated balloons and other cardiovascular diseases treatment.

show abstract

Epigallocatechin gallate mediated sandwich-like coating for mimicking endothelium with sustained therapeutic nitric oxide generation and heparin release

Cited by 77 publications

References 58 publications

A thrombin-triggered self-regulating anticoagulant strategy combined with anti-inflammatory capacity for blood-contacting implants

A thrombin-triggered self-regulating anticoagulant strategy combined with anti-inflammatory capacity for blood-contacting implants

Tissue‐Engineered Vascular Grafts: Emerging Trends and Technologies

Precise Regulation of Inflammation and Oxidative Stress by ROS‐Responsive Prodrug Coated Balloon for Preventing Vascular Restenosis

Contact Info

Product

Resources

About