Epigallocatechingallate attenuates myocardial injury in a mouse model of heart failure through TGF‑β1/Smad3 signaling pathway

Chen, Keyan; Chen, Wei; Liu, Shi Li; Wu, Tian; Yu, Kai; Qi, Jing; Wang, Yijun; Yao, Hui; Huang, Xiao Yang; Han, Ying; Hou, Ping

doi:10.3892/mmr.2018.8825

Cited by 17 publications

(23 citation statements)

References 37 publications

(37 reference statements)

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“…Recent animal studies confirm that EGCG significantly inhibits the inflammation in HF by disrupting the functioning of this particular signalling pathway. This correlates with the reduction in plasma concentrations of BNP and NT-proBNP, with improvement of left ventricular systolic function and of left ventricular dimensions, as well as with a survival index in this group of animals with HF [58]. The results of these studies give a preliminary theoretical basis for the treatment of the TGF-Beta1/Smad3 signalling pathway as a potential therapeutic target in HF.…”

Section: The Role Of the Tgf-beta1/smad3 Signalling Pathway In Inflamsupporting

confidence: 64%

“…In the animal HF model, it was also confirmed that the intensity of the inflammatory process within the myocardium is significantly reduced by inhibiting the TGF-Beta1/Smad3 signalling pathway [58]. Elevated serum concentrations of proinflammatory cytokines such as interleukin-1Beta (IL-1Beta), IL-6 and TNF-alpha, which are typical in HF, were significantly reduced by treatment with epigallocatechin gallate (EGCG), a substance that strongly inhibits the TGF-Beta1/Smad3 signalling pathway [58]. EGCG is a catechin, i.e.…”

Section: The Role Of the Tgf-beta1/smad3 Signalling Pathway In Inflammentioning

confidence: 73%

“…In addition, the inhibition of the TGF-Beta1/ Smad3 signalling pathway causes a reduction in plasma concentrations of pro-inflammatory cytokines such as IL-1Beta, IL-6 or TNF-alpha, all of which are elevated in HF. [58]. Increased expression of miR24 has been shown to inhibit the expression of TGF-Beta1 in CFs [89].…”

Section: The Participation Of Micro-rna In Inflammation In Hfmentioning

confidence: 99%

“…a monomeric aglycone, which belongs to the group of polyphenol compounds belonging to flavonoids. EGCG is obtained mainly from leaves or buds of Camellia sinensis [58]. EGCG is also common in many foods such as apples, apricots, cocoa, black and green tea, red wine and legumes [59].…”

Section: The Role Of the Tgf-beta1/smad3 Signalling Pathway In Inflammentioning

confidence: 99%

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Various aspects of inflammation in heart failure

et al. 2019

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Despite significant advances in the prevention and treatment of heart failure (HF), the prognosis in patients who have been hospitalised on at least one occasion due to exacerbation of HF is still poor. Therefore, a better understanding of the underlying pathophysiological mechanisms of HF is crucial in order to achieve better results in the treatment of this clinical syndrome. One of the areas that, for years, has aroused the interest of researchers is the activation of the immune system and the elevated levels of biomarkers of inflammation in patients with both ischaemic and non-ischaemic HF. Additionally, it is intriguing that the level of circulating pro-inflammatory biomarkers correlates with the severity of the disease and prognosis in this group of patients. Unfortunately, clinical trials aimed at assessing interventions to modulate the inflammatory response in HF have been disappointing, and the modulation of the inflammatory response has had either no effect or even a negative effect on the HF prognosis. The article presents a summary of current knowledge on the role of immune system activation and inflammation in the pathogenesis of HF. Understanding the immunological mechanisms pathogenetically associated with left ventricular remodelling and progression of HF may open up new therapeutic possibilities for HF.

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Section: The Role Of the Tgf-beta1/smad3 Signalling Pathway In Inflamsupporting

confidence: 64%

Section: The Role Of the Tgf-beta1/smad3 Signalling Pathway In Inflammentioning

confidence: 73%

Section: The Participation Of Micro-rna In Inflammation In Hfmentioning

confidence: 99%

Section: The Role Of the Tgf-beta1/smad3 Signalling Pathway In Inflammentioning

confidence: 99%

See 2 more Smart Citations

Various aspects of inflammation in heart failure

et al. 2019

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“…The results showed that when we inhibited this pathway, the apoptosis rate of cardiomyocytes induced by H/R reduced obviously, and the Bax and activated Cle-Caspase-3 protein expression levels reduced dramatically, but the Bcl-2 protein expression increased greatly. Research [26] has also confirmed that the apoptosis rate of cardiomyocytes can be reduced by inhibiting this pathway in HF mouse model. This also confirms our conclusion.…”

Section: Discussionmentioning

confidence: 84%

Effect of miR-195-5p on cardiomyocyte apoptosis in rats with heart failure by regulating TGF-β1/Smad3 signaling pathway

Xie

Lei

et al. 2020

Bioscience Reports

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Purpose: The present study set out to investigate the effect of miR-195-5p on cardiomyocyte apoptosis in rats with heart failure (HF) and its mechanism. Methods: HF rat model and hypoxia/reoxygenation (H/R) cardiomyocyte model were established. miR-195-5p expression and transforming growth factor-β1 (TGF-β1)/signal transduction protein (Smad)3 signaling pathway in HF rats and H/R cardiomyocytes were interfered. miR-195-5p expression was tested by Rt-PCR, TGF-β1/Smad3 signaling pathway related proteins were detected by Western Blot, apoptosis of HF rat cardiomyocytes was tested by TUNEL, and apoptosis of cardiomyocytes induced by H/R was checked by flow cytometry. Results: miR-195-5p was lowly expressed in myocardium of HF rats, while TGF-β1 and Smad3 proteins were high-expressed. Up-regulating miR-195-5p expression could obviously inhibit cardiomyocyte apoptosis of HF rats, improve their cardiac function, and inhibit activation of TGF-β1/Smad3 signaling pathway. Up-regulation of miR-195-5p expression or inhibition of TGF-β1/Smad3 signaling pathway could obviously inhibit H/R-induced cardiomyocyte apoptosis. Dual-luciferase reporter enzyme verified the targeted relationship between miR-195-5p and Smad3. Conclusion: miR-195-5p can inhibit cardiomyocyte apoptosis and improve cardiac function in HF rats by regulating TGF-β1/Smad3 signaling pathway, which may be a potential target for HF therapy.

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A green tea extract catechin EGCg: Therapeutic potential for pediatric cardiomyopathies

Quan

Gerber

et al. 2023

Pediatric Discovery

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Cardiomyopathies comprise a group of disorders wherein the primary defect is in cardiac myocytes. The common forms of pediatric cardiomyopathies, classified according to their morphological and functional manifestations, include dilated cardiomyopathy (DCM), restrictive cardiomyopathy (RCM), hypertrophic cardiomyopathy (HCM), and others. Cardiac gene mutations caused abnormal myofibril Ca2+ sensitivity may be involved in the underlying molecular mechanisms of cardiomyopathies. Thus far, no effective treatment for cardiomyopathies has been developed, especially for HCM and RCM in which diastolic dysfunction occurs early and followed by diastolic heart failure. Our laboratory is among the first in the field to investigate the mechanisms underlying various cardiomyopathies and search for the treatment for these disorders. In the past, we and other researchers have found that (−)‐epigallocatechin‐3‐gallate (EGCg), the major biomedical polyphenol extracted from green tea, possess multiple therapeutic effects on protecting cardiac function and correcting impaired relaxation. Given its therapeutic effects, EGCg might be a potential drug candidate for administration to patients with cardiomyopathy and heart failure. In this review, we will discuss the molecular mechanisms associated with the pathogenesis of diastolic dysfunction and summarize the pharmacological effects of EGCg on experimental animals and pediatric patients with cardiomyopathies and diastolic dysfunction.

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Epigallocatechingallate attenuates myocardial injury in a mouse model of heart failure through TGF‑β1/Smad3 signaling pathway

Cited by 17 publications

References 37 publications

Various aspects of inflammation in heart failure

Various aspects of inflammation in heart failure

Effect of miR-195-5p on cardiomyocyte apoptosis in rats with heart failure by regulating TGF-β1/Smad3 signaling pathway

A green tea extract catechin EGCg: Therapeutic potential for pediatric cardiomyopathies

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