2017
DOI: 10.1186/s13148-017-0345-3
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Epigenetic changes in blood leukocytes following an omega-3 fatty acid supplementation

Abstract: BackgroundOmega-3 polyunsaturated fatty acids (n-3 FAs) have several beneficial effects on cardiovascular (CV) disease risk factors. These effects on CV risk profile may be mediated by several factors, including epigenetic modifications. Our objective is to investigate, using genome-wide DNA methylation analyses, methylation changes following an n-3 FA supplementation in overweight and obese subjects and to identify specific biological pathways potentially altered by the supplementation.ResultsBlood leukocytes… Show more

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Cited by 82 publications
(46 citation statements)
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“…Some studies have detected reductions in inflammation post-exercise with FA supplementation [40,41], whereas, others have reported no change in inflammation [42,43]. An emerging mechanism for the anti-inflammatory impact of FA supplementation is via epigenetic modifications [44][45][46][47]. The supplementation of the diet with krill oil, high in n-3 PUFAs, has been demonstrated to reduce PPARGC1A mRNA expression and the change in mRNA expression was negatively correlated to the change in plasma n-3 PUFAs [48].…”
Section: Introductionmentioning
confidence: 99%
“…Some studies have detected reductions in inflammation post-exercise with FA supplementation [40,41], whereas, others have reported no change in inflammation [42,43]. An emerging mechanism for the anti-inflammatory impact of FA supplementation is via epigenetic modifications [44][45][46][47]. The supplementation of the diet with krill oil, high in n-3 PUFAs, has been demonstrated to reduce PPARGC1A mRNA expression and the change in mRNA expression was negatively correlated to the change in plasma n-3 PUFAs [48].…”
Section: Introductionmentioning
confidence: 99%
“…DNA methylation in particular is widely studied and has been shown to be a marker of environmental changes associated with disease (reviewed in [ 23 ]) and nutrition [ 3 , 24 , 25 ]. Identification of epigenetically-regulated pathways and molecules associated with these states have been instrumental in understanding the underlying molecular mechanisms associated with disease [ 26 , 27 , 28 ] or nutritional states [ 29 , 30 ] (reviewed in [ 31 ]). We hypothesized that the epigenetic signatures associated with fruit or juice intake will provide insight into the molecular mechanisms that underlie previously established physiological effects on immune function as well as allow assessment of the degree of shared and independent pathways between these two groups.…”
Section: Introductionmentioning
confidence: 99%
“…39,46 Other dietary interventions, such as polyunsaturated fatty acids, have shown beneficial effects, 82,83 and these might be at least partially mediated through or correlate with epigenetic changes. [84][85][86] However, epigenetic analyses have thus far only been performed in small cohorts, requiring further research and mechanistic studies to elucidate how polyunsaturated fatty acids influence epigenetic modifications.…”
Section: The Histone Code In Patients With Allergic Diseasesmentioning
confidence: 99%