Epigenetic Dysregulation of Insulin-like Growth Factor (IGF)-related Genes and Adverse Pregnancy Outcomes: A Systematic Review

Toure, Drissa; Baccaglini, Lorena; Opoku, Samuel T.; Barnes–Josiah, Debora; Cox, Roxanne; Hartman, Teresa; Klinkebiel, David

doi:10.3109/14767058.2016.1138465

Cited by 11 publications

(9 citation statements)

References 42 publications

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“…However, in the small infants who fail to catch up, genetic factors may also be important. Limited evidence supports a role for IGF-I receptor mutations in children born SGA [97], although there is some evidence that insulin-receptor polymorphism, previously associated with adult vascular and metabolic diseases and T2D, may also be associated with pregnancies complicated by SGA births [98]. Polymorphic variation in IGF binding protein-I and -3 axes may also play a role in the complex interaction between spontaneous growth, glucose homeostasis and lipid metabolism in short children born SGA [99,100].…”

Section: Heterogeneity Of Results Within and Between Studiesevidencementioning

confidence: 99%

What is the evidence for beneficial effects of growth hormone treatment beyond height in short children born small for gestational age? A review of published literature

Darendelıler

Kandemir

Harris

et al. 2019

Journal of Pediatric Endocrinology and Metabolism

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BackgroundAn increasing body of evidence supports the view that both an adverse intrauterine milieu and rapid postnatal weight gain in children born small for gestational age (SGA) contribute towards the risk for the development of chronic diseases in adult life.ContentThe aim of this review was to identify and summarize the published evidence on metabolic and cardiovascular risk, as well as risk of impaired cardiac function, intellectual capacity, quality of life, pubertal development and bone strength among children born SGA. The review will then address whether growth hormone (GH) therapy, commonly prescribed to reduce the height deficit in children born SGA who do not catch up in height, increases or decreases these risks over time.SummaryOverall, there are limited data in support of a modest beneficial effect of GH therapy on the adverse metabolic and cardiovascular risk observed in short children born SGA. Evidence to support a positive effect of GH on bone strength and psychosocial outcomes is less convincing.OutlookFurther evaluation into the clinical relevance of any potential long-term benefits of GH therapy on metabolic and cardiovascular endpoints is warranted.

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Section: Heterogeneity Of Results Within and Between Studiesevidencementioning

confidence: 99%

What is the evidence for beneficial effects of growth hormone treatment beyond height in short children born small for gestational age? A review of published literature

Darendelıler

Kandemir

Harris

et al. 2019

Journal of Pediatric Endocrinology and Metabolism

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“…During childhood, GH status in IUGR is not completely clear. GH responses to provocative stimulation tests and serum levels of IGF-1 and IGFBP-3 are reported to be normal in the majority of patients with normal IGF bioavailability [ 173 , 174 ]. However, in some studies, high pulse frequency and attenuated pulse amplitude related to GH secretion, have been reported [ 173 , 174 ].…”

Section: Specific Changes In the Gh–igf Axis Igf System And Growmentioning

confidence: 99%

“…GH responses to provocative stimulation tests and serum levels of IGF-1 and IGFBP-3 are reported to be normal in the majority of patients with normal IGF bioavailability [ 173 , 174 ]. However, in some studies, high pulse frequency and attenuated pulse amplitude related to GH secretion, have been reported [ 173 , 174 ]. These authors described reduced IGF-1, IGF-2, and IGFBP-3 serum concentrations, and reduced spontaneous GH secretion also [ 175 , 176 ].…”

Section: Specific Changes In the Gh–igf Axis Igf System And Growmentioning

confidence: 99%

Inflammatory Diseases and Growth: Effects on the GH–IGF Axis and on Growth Plate

Cirillo

Lazzeroni

Sartori

et al. 2017

IJMS

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This review briefly describes the most common chronic inflammatory diseases in childhood, such as cystic fibrosis (CF), inflammatory bowel diseases (IBDs), juvenile idiopathic arthritis (JIA), and intrauterine growth restriction (IUGR) that can be considered, as such, for the changes reported in the placenta and cord blood of these subjects. Changes in growth hormone (GH) secretion, GH resistance, and changes in the insulin-like growth factor (IGF) system are described mainly in relationship with the increase in nuclear factor-κB (NF-κB) and pro-inflammatory cytokines. Changes in the growth plate are also reported as well as a potential role for microRNAs (miRNAs) and thus epigenetic changes in chronic inflammation. Many mechanisms leading to growth failure are currently known; however, it is clear that further research in the field is still warranted.

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“…The placental epigenome plays a key role in regulating embryonic growth and development. Alterations in embryonic placental DNA methylation, frequently occurring at imprinted genes, have been associated with adverse pregnancy complications including preterm birth, intrauterine growth restriction and preeclampsia [12,13]. Genomic imprinting is a phenomenon that leads to monoallelic gene expression based on parental-origin [14].…”

Section: Introductionmentioning

confidence: 99%

Advanced paternal age directly impacts mouse embryonic placental imprinting

et al. 2020

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The placental epigenome plays a critical role in regulating mammalian growth and development. Alterations to placental methylation, often observed at imprinted genes, can lead to adverse pregnancy complications such as intrauterine growth restriction and preterm birth. Similar associations have been observed in offspring derived from advanced paternal age fathers. As parental age at time of conception continues to rise, the impact of advanced paternal age on these reproductive outcomes is a growing concern, but limited information is available on the molecular mechanisms affected in utero. This longitudinal murine research study thus investigated the impact of paternal aging on genomic imprinting in viable F1 embryonic portions of the placentas derived from the same paternal males when they were young (4-6 months) and when they aged (11-15 months). The use of a controlled outbred mouse model enabled analysis of offspring throughout the natural lifetime of the same paternal males and excluded confounding factors like female age or infertility. Firstly, paternal age significantly impacted embryonic placental weight, fetal weight and length. Targeted bisulfite sequencing was utilized to examine imprinted methylation at the Kcnq1ot1 imprinting control region, with significant hypermethylation observed upon natural paternal aging. Quantitative real-time PCR assessed imprinted gene expression levels at various imprinting clusters, resulting in transcript level alterations attributable to advanced paternal age. In summary, our results demonstrate a paternal age effect with dysregulation at numerous imprinted loci, providing a mechanism for future adverse placental and offspring health conditions.

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Epigenetic Dysregulation of Insulin-like Growth Factor (IGF)-related Genes and Adverse Pregnancy Outcomes: A Systematic Review

Abstract: Overall, evidence of an association between epigenetic abnormalities of IGF-related genes and LBW or SGA was weak and inconsistent. Methodological concerns limited results validity.

Cited by 11 publications

References 42 publications

What is the evidence for beneficial effects of growth hormone treatment beyond height in short children born small for gestational age? A review of published literature

What is the evidence for beneficial effects of growth hormone treatment beyond height in short children born small for gestational age? A review of published literature

Inflammatory Diseases and Growth: Effects on the GH–IGF Axis and on Growth Plate

Advanced paternal age directly impacts mouse embryonic placental imprinting

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