Epigenetic inheritance through the female germ-line: The known, the unknown, and the possible

Clarke, Hugh J.; Vieux, Karl-Frédéric

doi:10.1016/j.semcdb.2015.07.003

Cited by 60 publications

(51 citation statements)

References 122 publications

(155 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Maternal gametes (oocytes) also have a unique epigenetic profile, as well as a cargo of RNA species and proteins that are mostly acquired over the four months of maturation before ovulation 68 . Both animal and human studies have shown that the preconception environment may alter oocyte maturation 69 with maternal obesity affecting the metabolism of the developing ova and early offspring growth 70,71 .…”

Section: Mechanisms Involving Parental Gametesmentioning

confidence: 99%

Adolescence and the next generation

Patton

Olsson

Skirbekk

et al. 2018

Nature

290

228

View full text Add to dashboard Cite

Adolescent growth and social development shape the early development of offspring from preconception through to the post-partum period through distinct processes in males and females. At a time of great change in the forces shaping adolescence, including the timing of parenthood, investments in today’s adolescents, the largest cohort in human history, will yield great dividends for future generations.

show abstract

Section: Mechanisms Involving Parental Gametesmentioning

confidence: 99%

Adolescence and the next generation

Patton

Olsson

Skirbekk

et al. 2018

Nature

290

228

View full text Add to dashboard Cite

show abstract

“…This de novo methylation step leads to an oocyte specific methylome (Stewart et al, 2016). Histones are also very dynamically modified during oocyte growth (Clarke & Vieux, 2015). DNA and histone methylation reactions by methyltransferase enzymes require S-adenosyl methionine (SAM) as a methyl group donor.…”

Section: From the Oocyte To The Embryomentioning

confidence: 99%

Long term effects of ART: What do animals tell us?

Duranthon

Chavatte‐Palmer

2018

Molecular Reproduction Devel

View full text Add to dashboard Cite

Early stages of mammalian embryonic development are now known to be very sensitive to their microenvironment, with long term effects on fetal, postnatal, and adult health, thus extending to these early stages the concept of Developmental Origin of Health and Disease (DoHaD). In this scientific context, and with 3% of births in developed countries, safety of Assisted Reproductive Techniques procedures becomes a matter of concern. Besides, embryo technologies in domestic mammals, using huge number of embryos, do not seem to evidence heavy impacts on adult phenotypes. This paper first discusses what can or cannot be concluded from farm animal data, then develops long term effects of ART procedures (ovarian stimulation, in vitro fertilization and embryo culture) evidenced in model species (mainly mouse model). Recent literature demonstrates both individual and cumulative effects of each ART procedure on fetal and postnatal phenotypes. In a second part, because they are sources for further perturbations, immediate effects of ART on early embryo phenotypes at the cellular and molecular levels are described in both farm animals and model species. Mechanistic hypotheses supporting these ART induced phenotypic alterations are subsequently considered. Finally, taking into account interspecies differences in the mechanisms likely to be involved, the relevance of results obtained in animal models for human ART are discussed.

show abstract

“…By contrast, unique paternally-mediated effects on offspring implicate indirect effects on the fetal component of the placenta, seminal fluid proteins, or sperm epigenetic mechanisms (refer to Table 1 for detailed citations). Due to space restriction, we will only briefly review maternal effects on intergenerational disease transmission, and focus on paternal lineage mediated phenotypes in greater detail; for deeper information on the maternal lineage please refer to other reviews (Alfaradhi and Ozanne, 2011; Clarke and Vieux, 2015; Ferguson-Smith and Patti, 2011; Rando and Simmons, 2015). …”

Section: Experimental Models Of Multigenerational Disease Riskmentioning

confidence: 99%

Epigenetic Mechanisms of Transmission of Metabolic Disease across Generations

2017

View full text Add to dashboard Cite

Both human and animal studies indicate that environmental exposures experienced during early life can robustly influence risk for adult disease. Moreover, environmental exposures experienced by parents during either intrauterine or postnatal life can also influence the health of their offspring, thus initiating a cycle of disease risk across generations. In this perspective, we focus on epigenetic mechanisms in germ cells, including DNA methylation, histone modification, and non-coding RNAs, which collectively may provide a non-genetic molecular legacy of prior environmental exposures and influence transcriptional regulation, developmental trajectories, and adult disease risk in offspring.

show abstract

Epigenetic inheritance through the female germ-line: The known, the unknown, and the possible

Cited by 60 publications

References 122 publications

Adolescence and the next generation

Adolescence and the next generation

Long term effects of ART: What do animals tell us?

Epigenetic Mechanisms of Transmission of Metabolic Disease across Generations

Contact Info

Product

Resources

About