2018
DOI: 10.1016/j.archoralbio.2017.12.029
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Epigenetic mechanisms in odontogenic tumors: A literature review

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Cited by 20 publications
(25 citation statements)
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References 87 publications
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“…Because the clinical features are not typical, correct pathological diagnosis has great significance . Although it is believed that AC is derived from the dental embryonic remnants or entrapped salivary gland epithelium, the origin cells are unknown . Microscopic observation of AM is characterized by benign cytological features, whereas AC has the pathological manifestations of AM and exhibits some degree of cellular pleomorphism, nuclear mitosis, local necrosis, perineural infiltration, and nuclear hyperchromatism.…”
Section: Discussionmentioning
confidence: 99%
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“…Because the clinical features are not typical, correct pathological diagnosis has great significance . Although it is believed that AC is derived from the dental embryonic remnants or entrapped salivary gland epithelium, the origin cells are unknown . Microscopic observation of AM is characterized by benign cytological features, whereas AC has the pathological manifestations of AM and exhibits some degree of cellular pleomorphism, nuclear mitosis, local necrosis, perineural infiltration, and nuclear hyperchromatism.…”
Section: Discussionmentioning
confidence: 99%
“…Inclusion criteria were case reports, case series, and retrospective studies of AC. Exclusion criteria were studies of malignant AM, conference abstracts, reviews, and unavailable full texts . Full‐length studies of publications were extracted for inclusion, and clinical features (age, site, sex), treatment, metastasis, recurrence, follow‐up, and outcome were recorded.…”
Section: Methodsmentioning
confidence: 99%
“…DNA methylation refers to a process of methylation at the fifth position of cytosine (5mC), and majority of this process occurs at CpG sites . Human whole genome is partially in low CpG situation.…”
Section: Dna Methylation and Tumorigenesismentioning
confidence: 99%
“…HBx represses promoter of p16INK4a by inducing hypermethylation; consequently, activated CDKs unbind pRb from E2F via phosphorylation and result in DNMT1 transcription. DNMT1, in turn, represses p16INK4a transcription . DNMT1, DNMT3A1, and DNMT3A2 mediate hypermethylation of IGFBP promoter .…”
Section: Hepatitis B Virusmentioning
confidence: 99%
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