Epigenetic modulation of the developing serotonergic neurotransmission in the semi-precocial rodent Octodon degus

Jezierski, Grzegorz; Braun, Katharina; Gruss, Michael

doi:10.1016/j.neuint.2005.11.009

Cited by 14 publications

(6 citation statements)

References 34 publications

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“…Also, it has been shown that different parameters in the hypothalamus such as cell death and proliferation as well as astrocyte and synaptic markers, respond differentially in males and females following both, prenatal and adult stress exposure (Garcia-Caceres et al, 2010). There is also evidence for sex-specific changes in neurochemical profiles regarding dopaminergic, serotonergic and GABAergic systems in rats and degus in response to early stress (Reznikov et al, 1999; Ziabreva et al, 2003; Jezierski et al, 2006; Barbosa Neto et al, 2012; Leon Rodriguez and Duenas, 2013). …”

Section: Vulnerability and Resilience Towards Early Life Stress: Sex mentioning

confidence: 99%

Perinatal programming of emotional brain circuits: an integrative view from systems to molecules

et al. 2014

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Environmental influences such as perinatal stress have been shown to program the developing organism to adapt brain and behavioral functions to cope with daily life challenges. Evidence is now accumulating that the specific and individual effects of early life adversity on the functional development of brain and behavior emerge as a function of the type, intensity, timing and the duration of the adverse environment, and that early life stress (ELS) is a major risk factor for developing behavioral dysfunctions and mental disorders. Results from clinical as well as experimental studies in animal models support the hypothesis that ELS can induce functional “scars” in prefrontal and limbic brain areas, regions that are essential for emotional control, learning and memory functions. On the other hand, the concept of “stress inoculation” is emerging from more recent research, which revealed positive functional adaptations in response to ELS resulting in resilience against stress and other adversities later in life. Moreover, recent studies indicate that early life experiences and the resulting behavioral consequences can be transmitted to the next generation, leading to a transgenerational cycle of adverse or positive adaptations of brain function and behavior. In this review we propose a unifying view of stress vulnerability and resilience by connecting genetic predisposition and programming sensitivity to the context of experience-expectancy and transgenerational epigenetic traits. The adaptive maturation of stress responsive neural and endocrine systems requires environmental challenges to optimize their functions. Repeated environmental challenges can be viewed within the framework of the match/mismatch hypothesis, the outcome, psychopathology or resilience, depends on the respective predisposition and on the context later in life.

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Section: Vulnerability and Resilience Towards Early Life Stress: Sex mentioning

confidence: 99%

Perinatal programming of emotional brain circuits: an integrative view from systems to molecules

et al. 2014

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“…Stress and toxic effects could be the causes for dysregulated serotonergic neurotransmission (Heinz et al 2001); this has recently been confirmed in studies with rodents, where early parental separation has been found to influence the developing serotonergic system (Jezierski et al 2006). There is evidence that not all individuals are equally vulnerable to stress effects, and that their impact is modulated by the genetic constitution, e.g., of the serotonin transporter, thus promoting depression, anxiety, and alcohol abuse in the presence of different levels of negative life events (Caspi et al 2003).…”

Section: Dysfunction Of the Brain Reward System In Alcohol And Nicotimentioning

confidence: 83%

Behavioral Neuroscience of Drug Addiction

Self¹

2010

Current Topics in Behavioral Neurosciences

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About this seriesCurrent Topics in Behavioral Neurosciences provides critical and comprehensive discussions of the most significant areas of behavioral neuroscience research, written by leading international authorities. Each volume offers an informative and contemporary account of its subject, making it an unrivalled reference source. Titles in this series are available in both print and electronic formats.With the development of new methodologies for brain imaging, genetic and genomic analyses, molecular engineering of mutant animals, novel routes for drug delivery, and sophisticated cross-species behavioral assessments, it is now possible to study behavior relevant to psychiatric and neurological diseases and disorders on the physiological level. The Behavioral Neurosciences series focuses on ''translational medicine'' and cutting-edge technologies. Preclinical and clinical trials for the development of new diagnostics and therapeutics as well as prevention efforts are covered whenever possible. This work is subject to copyright. All rights are reserved, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilm or in any other way, and storage in data banks. Duplication of this publication or parts thereof is permitted only under the provisions of the German Copyright Law of September 9, 1965, in its current version, and permission for use must always be obtained from Springer. Violations are liable to prosecution under the German Copyright Law. The use of general descriptive names, registered names, trademarks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. Product liability: The publishers cannot guarantee the accuracy of any information about dosage and application contained in this book. In every individual case the user must check such information by consulting the relevant literature.Cover illustration: Artistic representation of oscillatory synchrony and timing of neurons in networks by Gyorgy BuzsakiCover design: WMXDesign GmbH, Heidelberg, GermanyPrinted on acid-free paper Springer is part of Springer Science+Business Media (www.springer.com) PrefaceDrug addiction is a chronically relapsing mental illness involving severe motivational disturbances and loss of behavioral control leading to personal devastation. The disorder afflicts millions of people, often co-occurring with other mental illnesses with enormous social and economic costs to society. Several decades of research have established that drugs of abuse hijack the brain's natural reward substrates, and that chronic drug use causes aberrant alterations in these rewardprocessing systems. Such aberrations may be demonstrated at the cellular, neurotransmitter, and regional levels of information processing using either animal models or neuroimaging in humans following chron...

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Section: Defining Dependence: Clinical Definitions and Complexities Imentioning

confidence: 83%

Neural Markers of Genetic Vulnerability to Drug Addiction

Müller

Likhodi

Heinz

2009

Behavioral Neuroscience of Drug Addiction

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This chapter will summarize genetics findings derived from various strategies and highlight important neural markers (or correlates) in some specific and extensively studied genes. Most studies highlighted here focus on alcohol and nicotine dependence (AD and ND, respectively). AD and ND are among the most prevalent addictive disorders worldwide, are among the best studied, and are also associated globally with the largest socioeconomic impact.We describe different mechanisms through which genes can have an impact on the addictive behaviors, distinguishing between the genes that inscribe the proteins affecting the metabolism of the addictive substance (e.g., ADH/ALDH for alcohol or CYP2A6 for nicotine) and genes that code for the brain transmitter systems, such as genes involved in cerebral neurotransmission thought to be involved in addiction (e.g., brain reward system, mood regulation, opioid system). Strategies include linkage analyses, association studies, whole genome association studies as well as intermediate/endophenotype studies. Moreover, some important findings derived from animal studies and from neuroimaging studies are highlighted. In conclusion, we provide the reader with an overview of most important studies related to AD and ND and give an outlook how these findings may become useful and beneficial in the future.

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Epigenetic modulation of the developing serotonergic neurotransmission in the semi-precocial rodent Octodon degus

Cited by 14 publications

References 34 publications

Perinatal programming of emotional brain circuits: an integrative view from systems to molecules

Perinatal programming of emotional brain circuits: an integrative view from systems to molecules

Behavioral Neuroscience of Drug Addiction

Neural Markers of Genetic Vulnerability to Drug Addiction

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