“…A number of studies reported associations between polymorphisms in the SLC6A4 gene, MDD, and related traits, such as anxiety (Heinz et al, 2005;Munafo, Brown, & Hariri, 2008;Surguladze et al, 2008) and AD treatment response (Manoharan, Shewade, Rajkumar, & Adithan, 2016). Fewer studies investigated the role of the ARC gene, despite it being considered a strong candidate for involvement in MDD and AD response (Dyrvig, Gotzsche, Woldbye, & Lichota, 2015;Li et al, 2015;Molteni, Calabrese, Mancini, Racagni, & Riva, 2008). Indeed, ARC is an early onset gene with an important role in neuroplasticity (Li et al, 2015;Peebles et al, 2010).…”